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    DLC1 DLC1 Rho GTPase activating protein [ Homo sapiens (human) ]

    Gene ID: 10395, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover.

    DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover.
    Hooglugt A, van der Stoel MM, Shapeti A, Neep BF, de Haan A, van Oosterwyck H, Boon RA, Huveneers S., Free PMC Article

    05/10/2024
    Aberrant DNA Methylation Patterns of Deleted in Liver Cancer 1 Isoforms in Hepatocellular Carcinoma.

    Aberrant DNA Methylation Patterns of Deleted in Liver Cancer 1 Isoforms in Hepatocellular Carcinoma.
    Pan J, Li D, Fan X, Cheng J, Jin S, Chen P, Lin H, Li Y.

    03/20/2023
    NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis.

    NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis.
    Wang CS, Zhang XB, Zhu XT, Chen RS.

    10/22/2022
    Frequent Downregulation and Promoter Hypermethylation of DLC1: Relationship with Clinical Outcome in Gallbladder Cancer.

    Frequent Downregulation and Promoter Hypermethylation of DLC1: Relationship with Clinical Outcome in Gallbladder Cancer.
    Singh D, Bharti A, Biswas D, Tewari M, Kar AG, Ansari MA, Singh S, Narayan G.

    06/18/2022
    MiR-200a-3p promotes gastric cancer progression by targeting DLC-1.

    MiR-200a-3p promotes gastric cancer progression by targeting DLC-1.
    Li Z, Wang Y, Liu S, Li W, Wang Z, Jia Z, Zhu Z, Bao Y.

    03/26/2022
    The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.

    The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.
    Sanchez-Solana B, Wang D, Qian X, Velayoudame P, Simanshu DK, Acharya JK, Lowy DR., Free PMC Article

    02/26/2022
    Association of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infection.

    Association of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infection.
    Riazalhosseini B, Mohamed R, Devi Apalasamy Y, Mohamed Z.

    01/29/2022
    DLC1 inhibits lung adenocarcinoma cell proliferation, migration and invasion via regulating MAPK signaling pathway.

    DLC1 inhibits lung adenocarcinoma cell proliferation, migration and invasion via regulating MAPK signaling pathway.
    Niu N, Ma X, Liu H, Zhao J, Lu C, Yang F, Qi W.

    01/22/2022
    CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1.

    CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1.
    Li J, Bao S, Wang L, Wang R.

    12/11/2021
    MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1.

    MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1.
    Liu H, Ma X, Niu N, Zhao J, Lu C, Yang F, Qi W., Free PMC Article

    11/13/2021
    DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.

    DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.
    van der Stoel M, Schimmel L, Nawaz K, van Stalborch AM, de Haan A, Klaus-Bergmann A, Valent ET, Koenis DS, van Nieuw Amerongen GP, de Vries CJ, de Waard V, Gloerich M, van Buul JD, Huveneers S.

    08/7/2021
    Tumor suppressor gene DLC1: Its modifications, interactive molecules, and potential prospects for clinical cancer application.

    Tumor suppressor gene DLC1: Its modifications, interactive molecules, and potential prospects for clinical cancer application.
    Ren G, Li G.

    07/31/2021
    Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.

    Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.
    Zhang G, Li J, Sun H, Yang G.

    07/31/2021
    Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR.

    Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR.
    Liu H, Lan T, Li H, Xu L, Chen X, Liao H, Chen X, Du J, Cai Y, Wang J, Li X, Huang J, Yuan K, Zeng Y., Free PMC Article

    07/24/2021
    TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma.

    TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma.
    Duan J, Qian Y, Fu X, Chen M, Liu K, Liu H, Yang J, Liu C, Chang Y., Free PMC Article

    07/24/2021
    MicroRNA-141-3p promoted the progression of nasopharyngeal carcinoma through targeting DLC1.

    MicroRNA-141-3p promoted the progression of nasopharyngeal carcinoma through targeting DLC1.
    Mu JW, Zhou XY, Wang QJ, Han LH, Jiao JB.

    07/3/2021
    Oncogenic Role of miR-200c-3p in High-Grade Serous Ovarian Cancer Progression via Targeting the 3'-Untranslated Region of DLC1.

    Oncogenic Role of miR-200c-3p in High-Grade Serous Ovarian Cancer Progression via Targeting the 3'-Untranslated Region of DLC1.
    Ankasha SJ, Shafiee MN, Abdul Wahab N, Raja Ali RA, Mokhtar NM., Free PMC Article

    07/3/2021
    Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression.

    Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression.
    Zhou X, Jiao D, Dou M, Zhang W, Lv L, Chen J, Li L, Wang L, Han X., Free PMC Article

    05/15/2021
    Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.

    Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
    Holub AS, Bouley RA, Petreaca RC, Husbands AY., Free PMC Article

    03/20/2021
    A tumor suppressor DLC1: The functions and signal pathways.

    A tumor suppressor DLC1: The functions and signal pathways.
    Zhang Y, Li G.

    03/13/2021
    circRNA-associated ceRNA network construction reveals the circRNAs involved in the progression and prognosis of breast cancer.

    circRNA-associated ceRNA network construction reveals the circRNAs involved in the progression and prognosis of breast cancer.
    Ma X, Liu C, Gao C, Li J, Zhuang J, Liu L, Li H, Wang X, Zhang X, Dong S, Zhou C, Sun C.

    02/6/2021
    Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function.

    Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function.
    Wang D, Qian X, Sanchez-Solana B, Tripathi BK, Durkin ME, Lowy DR., Free PMC Article

    01/16/2021
    Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.

    Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
    Yang X, Hu F, Liu JA, Yu S, Cheung MPL, Liu X, Ng IO, Guan XY, Wong KKW, Sharma R, Lung HL, Jiao Y, Lee LTO, Cheung M., Free PMC Article

    11/28/2020
    Inhibition of miR-141 and miR-200a Increase DLC-1 and ZEB2 Expression, Enhance Migration and Invasion in Metastatic Serous Ovarian Cancer.

    Inhibition of miR-141 and miR-200a Increase DLC-1 and ZEB2 Expression, Enhance Migration and Invasion in Metastatic Serous Ovarian Cancer.
    Wahab NA, Othman Z, Nasri NWM, Mokhtar MH, Ibrahim SF, Hamid AA, Raja Ali RA, Mokhtar NM., Free PMC Article

    09/26/2020
    DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA.

    DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA.
    Joshi R, Qin L, Cao X, Zhong S, Voss C, Min W, Li SSC., Free PMC Article

    09/19/2020
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