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    KLF2 KLF transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 10365, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension.

    N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension.
    Kang K, Xiang J, Zhang X, Xie Y, Zhou M, Zeng L, Zhuang J, Kuang J, Lin Y, Hu B, Xiong Q, Yin Q, Su Q, Liao X, Wang J, Niu Y, Liu C, Tian J, Gou D., Free PMC Article

    07/12/2024
    KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis.

    KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis.
    Singh MK, Rallabandi HR, Zhou XJ, Qi YY, Zhao ZZ, Gan T, Zhang H, Looger LL, Nath SK.,

    06/25/2024
    HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells.

    HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells.
    Tamargo IA, Baek KI, Xu C, Kang DW, Kim Y, Andueza A, Williams D, Demos C, Villa-Roel N, Kumar S, Park C, Choi R, Johnson J, Chang S, Kim P, Tan S, Jeong K, Tsuji S, Jo H.,

    04/16/2024
    KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy.

    KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy.
    Prateeksha P, Naidu P, Das M, Barthels D, Das H.

    12/1/2023
    KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3.

    KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3.
    Gong Z, Shu Z, Zhou Y, Chen Y, Zhu H.

    09/29/2023
    KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1.

    KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1.
    Cheng X, Shen C, Liao Z.

    08/30/2023
    Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis.

    Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis.
    Huang S, Zhao J, Yu H, Chen G.

    08/19/2023
    Kruppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing.

    Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing.
    Wittner J, Schuh W., Free PMC Article

    06/3/2023
    Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer.

    Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer.
    Zhou Y, Liu H, Wang R, Zhang M., Free PMC Article

    03/28/2023
    Differentiated serum levels of Kruppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus.

    Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus.
    Zhang H, Chen Z, Wang X.

    03/7/2023
    Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression.

    Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression.
    Song J, Kim SJ, Gollamudi J, Thiagarajan P, Prchal JT., Free PMC Article

    03/6/2023
    Down-regulation of KLF2 in lung fibroblasts is linked with COVID-19 immunofibrosis and restored by combined inhibition of NETs, JAK-1/2 and IL-6 signaling.

    Down-regulation of KLF2 in lung fibroblasts is linked with COVID-19 immunofibrosis and restored by combined inhibition of NETs, JAK-1/2 and IL-6 signaling.
    Chrysanthopoulou A, Antoniadou C, Natsi AM, Gavriilidis E, Papadopoulos V, Xingi E, Didaskalou S, Mikroulis D, Tsironidou V, Kambas K, Koffa M, Skendros P, Ritis K., Free PMC Article

    02/22/2023
    Dysregulation of Kruppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.

    Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
    Samak M, Kues A, Kaltenborn D, Klösener L, Mietsch M, Germena G, Hinkel R., Free PMC Article

    02/16/2023
    Heterozygous premature termination in zinc-finger domain of Kruppel-like factor 2 gene associates with dysregulated immunity.

    Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity.
    Pernaa N, Keskitalo S, Chowdhury I, Nissinen A, Glumoff V, Keski-Filppula R, Junttila J, Eklund KK, Santaniemi W, Siitonen S, Seppänen MR, Vähäsalo P, Varjosalo M, Åström P, Hautala T., Free PMC Article

    12/10/2022
    miR-92a-3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis.

    miR-92a-3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis.
    Yu ZH, Chen ZH, Zhou GL, Zhou XJ, Ma HY, Yu Y, Wang X, Cao XC., Free PMC Article

    11/5/2022
    Kruppel-like Factor 2 Inhibits Proliferation in Renal Angiomyolipoma via IL-6/JAK/STAT3 Signaling Pathway.

    Kruppel-like Factor 2 Inhibits Proliferation in Renal Angiomyolipoma via IL-6/JAK/STAT3 Signaling Pathway.
    Liu CY, Chang TH, Hsieh CH, Chang YH, Pang JS, Chuang CK.

    10/15/2022
    Relation among EGFL7, ITGB3, and KLF2 and their clinical implication in multiple myeloma patients: a prospective study.

    Relation among EGFL7, ITGB3, and KLF2 and their clinical implication in multiple myeloma patients: a prospective study.
    Li Y, Zhang L, Gong J., Free PMC Article

    10/1/2022
    Long non-coding RNA SNHG1 promotes bladder cancer progression by upregulating EZH2 and repressing KLF2 transcription.

    Long non-coding RNA SNHG1 promotes bladder cancer progression by upregulating EZH2 and repressing KLF2 transcription.
    Min J, Ma J, Wang Q, Yu D., Free PMC Article

    10/1/2022
    KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.

    KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.
    Li M, Zhang M, Chen M, Xiao J, Mu X, Peng J, Fan J., Free PMC Article

    07/16/2022
    MiR-572 promotes the development of non-small cell lung cancer by targeting KLF2.

    MiR-572 promotes the development of non-small cell lung cancer by targeting KLF2.
    Sun B, Zhao J, Shao ZY.

    05/28/2022
    KLF2 mediates the suppressive effect of BDNF on diabetic intimal calcification by inhibiting HK1 induced endothelial-to-mesenchymal transition.

    KLF2 mediates the suppressive effect of BDNF on diabetic intimal calcification by inhibiting HK1 induced endothelial-to-mesenchymal transition.
    Wang FF, Zhang JL, Ji Y, Yan XJ, Sun L, Zhu Y, Jin H.

    05/7/2022
    Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer.

    Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer.
    Ma Z, Wei K, Yang F, Guo Z, Pan C, He Y, Wang J, Li Z, Chen L, Chen Y, Xia Y., Free PMC Article

    01/29/2022
    KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling.

    KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling.
    Huang J, Pu Y, Zhang H, Xie L, He L, Zhang CL, Cheng CK, Huo Y, Wan S, Chen S, Huang Y, Lau CW, Wang L, Xia Y, Huang Y, Luo JY.

    01/15/2022
    KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma.

    KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma.
    Lu Y, Qin H, Jiang B, Lu W, Hao J, Cao W, Du L, Chen W, Zhao X, Guo H.

    01/8/2022
    Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Kruppel-like Factor 2 Pathway in Endothelial Cells.

    Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Krüppel-like Factor 2 Pathway in Endothelial Cells.
    Wu CH, Chiu YL, Hsieh CY, Tsung GS, Wu LS, Cheng CC, Tsai TN., Free PMC Article

    11/6/2021
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