| Reprint of: Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders. | Reprint of: Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders.
Jin L, Li Y, Luo S, Peng Q, Zhai QX, Zhai JX, Gao LD, Guo JJ, Song W, Yi YH, He N, Chen YJ. | 04/12/2024 |
| Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders. | Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders.
Jin L, Li Y, Luo S, Peng Q, Zhai QX, Zhai JX, Gao LD, Guo JJ, Song W, Yi YH, He N, Chen YJ. | 11/1/2023 |
| High miR-3648 expression and low APC2 expression are associated with shorter survival and tumor progression in NSCLC. | High miR-3648 expression and low APC2 expression are associated with shorter survival and tumor progression in NSCLC.
Dong Y, Wu B, Wang X, Lu F, Li Q, Zhao Q. | 06/25/2022 |
| What are the roles of global DNA and APC 2 gene promotor hypermethylation in multiple myeloma? | What are the roles of global DNA and APC 2 gene promotor hypermethylation in multiple myeloma?
Pehlivan S, Serin I, Nursal AF, Oyaci Y, Gundes I, Pehlivan M., Free PMC Article | 03/5/2022 |
| Whole-exome sequencing in adult patients with developmental and epileptic encephalopathy: It is never too late. | Whole-exome sequencing in adult patients with developmental and epileptic encephalopathy: It is never too late.
Minardi R, Licchetta L, Baroni MC, Pippucci T, Stipa C, Mostacci B, Severi G, Toni F, Bergonzini L, Carelli V, Seri M, Tinuper P, Bisulli F. | 08/21/2021 |
| METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding. | METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z., Free PMC Article | 07/10/2021 |
| miR-3648 Promotes Prostate Cancer Cell Proliferation by Inhibiting Adenomatous Polyposis Coli 2. | miR-3648 Promotes Prostate Cancer Cell Proliferation by Inhibiting Adenomatous Polyposis Coli 2.
Xing R. | 06/19/2021 |
| findings identify APC2 as a radiographically distinguishable recessive form of lissencephaly | Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay.
Lee S, Chen DY, Zaki MS, Maroofian R, Houlden H, Di Donato N, Abdin D, Morsy H, Mirzaa GM, Dobyns WB, McEvoy-Venneri J, Stanley V, James KN, Mancini GMS, Schot R, Kalayci T, Altunoglu U, Karimiani EG, Brick L, Kozenko M, Jamshidi Y, Manzini MC, Beiraghi Toosi M, Gleeson JG., Free PMC Article | 04/4/2020 |
| Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling, and suppress the growth and metastasis of colorectal cancer | Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression.
Geng Y, Zheng X, Hu W, Wang Q, Xu Y, He W, Wu C, Zhu D, Wu C, Jiang J. | 03/7/2020 |
| These results demonstrate that the circ-PKD2/miR-204-3p/APC2 axis represents a novel pathway involved in the pathogenesis of oral squamous cell carcinoma (OSCC) and may serve as a novel therapeutic target of OSCC. | circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma.
Gao L, Zhao C, Li S, Dou Z, Wang Q, Liu J, Ren W, Zhi K. | 02/1/2020 |
| We have also identified a functionally important SUMO interacting motif in the cullin-homology domain of APC2 located near the APC4 sumoylation sites and APC/C catalytic core. Our findings provide evidence of an important regulatory role for SUMO modification and binding in affecting APC/C activation and mitotic exit. | Sumoylation promotes optimal APC/C Activation and Timely Anaphase.
Lee CC, Li B, Yu H, Matunis MJ., Free PMC Article | 07/6/2019 |
| Results report that APC2 was hypermethylated in colorectal cancer (CRC) tissues and cell lines. An inverse correlation was observed between the APC2 methylation and its transcriptional levels. Furthermore, APC2_CPG_14 was an independent risk factor for overall survival in CRC patients. This study indicates that APC2 is hypermethylated and may be a tumorigenesis biomarker for Chinese CRC patients. | Hypermethylation of APC2 Is a Predictive Epigenetic Biomarker for Chinese Colorectal Cancer.
He Y, Sun LY, Wang J, Gong R, Shao Q, Zhang ZC, Ye ZL, Wang HY, Xu RH, Shao JY., Free PMC Article | 03/30/2019 |
| It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. | APC2 controls dendrite development by promoting microtubule dynamics.
Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC., Free PMC Article | 12/22/2018 |
| double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. | miR-4326 promotes lung cancer cell proliferation through targeting tumor suppressor APC2.
Xu G, Zhang Z, Zhang L, Chen Y, Li N, Lv Y, Li Y, Xu X. | 07/14/2018 |
| APC2 3'-UTR is targeted by hsa-miR-11181. | Hsa-miR-11181 regulates Wnt signaling pathway through targeting of APC2 transcripts in SW480 cell line.
Dokanehiifard S, Soltani BM. | 11/18/2017 |
| Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium | Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.
Daly CS, Shaw P, Ordonez LD, Williams GT, Quist J, Grigoriadis A, Van Es JH, Clevers H, Clarke AR, Reed KR., Free PMC Article | 09/2/2017 |
| Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. | The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.
Croy HE, Fuller CN, Giannotti J, Robinson P, Foley AVA, Yamulla RJ, Cosgriff S, Greaves BD, von Kleeck RA, An HH, Powers CM, Tran JK, Tocker AM, Jacob KD, Davis BK, Roberts DM., Free PMC Article | 12/17/2016 |
| miR-939 functioned as a potential tumor promoter by regulating the Wnt/beta-catenin signal pathway through direct suppression of APC2 expression. | MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression.
Ying X, Li-ya Q, Feng Z, Yin W, Ji-hong L. | 02/13/2016 |
| We report that APC-2 gene is hypermethylated in both RB tumor samples and Y79 cells. Reduced APC-2 lead to increased Wnt signaling pathway protein, beta-catenin suggesting tumor suppressive role of APC-2 gene. | Hypermethylation of adenomatosis polyposis coli-2 and its tumor suppressor role in retinoblastoma.
Beta M, Chitipothu S, Khetan V, Biswas J, Krishnakumar S. | 01/23/2016 |
| APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation. | Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.
Schneikert J, Vijaya Chandra SH, Ruppert JG, Ray S, Wenzel EM, Behrens J., Free PMC Article | 02/8/2014 |
| These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. | Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.
Roberts DM, Pronobis MI, Poulton JS, Kane EG, Peifer M., Free PMC Article | 09/29/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| Familial adenomatous polyposis with adenomatous polyposis coli gene mutation at codon 1309 entails a risk of a more aggressive phenotype; early colectomy may be indicated in children harboring this gene mutation. | Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience.
Attard TM, Tajouri T, Peterson KD, Tinley S, Thorson AG, Lynch HT. | 01/21/2010 |