| A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8[-/y] mice. | A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8(-/y) mice.
Sugimoto C, Perna MK, Regan SL, Tepe EA, Liou R, Fritz AL, Williams MT, Vorhees CV, Skelton MR., | 01/30/2024 |
| Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency. | Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency.
Ghirardini E, Sagona G, Marquez-Galera A, Calugi F, Navarron CM, Cacciante F, Chen S, Di Vetta F, Dadà L, Mazziotti R, Lupori L, Putignano E, Baldi P, Lopez-Atalaya JP, Pizzorusso T, Baroncelli L., Free PMC Article | 03/9/2023 |
| Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. | Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis.
Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang HH, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P, Lindquist DM, DeGrauw T, Kuan CY., Free PMC Article | 03/26/2022 |
| Creatine transport and pathological changes in creatine transporter deficient mice. | Creatine transport and pathological changes in creatine transporter deficient mice.
Wawro AM, Gajera CR, Baker SA, Nirschl JJ, Vogel H, Montine TJ. | 01/22/2022 |
| Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness. | Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness.
Abdulla ZI, Pennington JL, Gutierrez A, Skelton MR. | 04/24/2021 |
| Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. | Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function.
Hall CHT, Lee JS, Murphy EM, Gerich ME, Dran R, Glover LE, Abdulla ZI, Skelton MR, Colgan SP., Free PMC Article | 04/17/2021 |
| Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice. | Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice.
Abdulla ZI, Pahlevani B, Lundgren KH, Pennington JL, Udobi KC, Seroogy KB, Skelton MR., Free PMC Article | 10/10/2020 |
| Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits. | Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits.
Udobi KC, Delcimmuto N, Kokenge AN, Abdulla ZI, Perna MK, Skelton MR., Free PMC Article | 09/19/2020 |
| Results show that the loss of cerebral Cr is responsible for the learning and memory deficits seen in ubiquitous Slc6a8(-/y) mice. | Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.
Udobi KC, Kokenge AN, Hautman ER, Ullio G, Coene J, Williams MT, Vorhees CV, Mabondzo A, Skelton MR., Free PMC Article | 11/10/2018 |
| There were no changes in mitochondrial respiration when normalized to mitochondrial number, suggesting that the increase in respiration observed could be to higher mitochondrial content in Crt (-/y) mice | Creatine transporter deficiency leads to increased whole body and cellular metabolism.
Perna MK, Kokenge AN, Miles KN, Udobi KC, Clark JF, Pyne-Geithman GJ, Khuchua Z, Skelton MR., Free PMC Article | 12/16/2017 |
| Our data suggest that brain Cr depletion causes both early intellectual disability and late progressive cognitive decline, and identify novel targets to design intervention strategies aimed at overcoming brain CCDS1 alterations. | A mouse model for creatine transporter deficiency reveals early onset cognitive impairment and neuropathology associated with brain aging.
Baroncelli L, Molinaro A, Cacciante F, Alessandrì MG, Napoli D, Putignano E, Tola J, Leuzzi V, Cioni G, Pizzorusso T. | 06/10/2017 |
| Ubiquitous CrT knockout mice have learning and memory deficits resembling human CrT deficiency | Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.
Skelton MR, Schaefer TL, Graham DL, Degrauw TJ, Clark JF, Williams MT, Vorhees CV., Free PMC Article | 08/6/2011 |
| myocardial creatine transporter has a role in progressive heart failure and decreased glycolytic capacity | Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
Phillips D, Ten Hove M, Schneider JE, Wu CO, Sebag-Montefiore L, Aponte AM, Lygate CA, Wallis J, Clarke K, Watkins H, Balaban RS, Neubauer S., Free PMC Article | 11/27/2010 |
| AMPK inhibits apical membrane CRT/Slc6a8 expression in kidney proximal tubule cells, which could be important in reducing cellular energy expenditure and unnecessary creatine reabsorption under conditions of local and whole body metabolic stress. | Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.
Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR., Free PMC Article | 07/19/2010 |
| This study reveals the presence of a novel SLC6A8 splice variant, SLC6A8C in human and mouse. | Identification, characterization and cloning of SLC6A8C, a novel splice variant of the creatine transporter gene.
Martínez-Muñoz C, Rosenberg EH, Jakobs C, Salomons GS. | 01/21/2010 |
| Thus, the creatine transporter is required for creatine uptake through the plasma membrane of brain neurons. | The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds.
Lunardi G, Parodi A, Perasso L, Pohvozcheva AV, Scarrone S, Adriano E, Florio T, Gandolfo C, Cupello A, Burov SV, Balestrino M. | 01/21/2010 |
| This induction of creatine transport activity by hypertonicity is not confined to muscle cells: a similar induction was shown in porcine endothelial cells. | Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress.
Alfieri RR, Bonelli MA, Cavazzoni A, Brigotti M, Fumarola C, Sestili P, Mozzoni P, De Palma G, Mutti A, Carnicelli D, Vacondio F, Silva C, Borghetti AF, Wheeler KP, Petronini PG., Free PMC Article | 01/21/2010 |