| Prelamin A and ZMPSTE24 in premature and physiological aging. | Prelamin A and ZMPSTE24 in premature and physiological aging.
Worman HJ, Michaelis S., Free PMC Article | 11/16/2023 |
| Analysis of a non-lethal biallelic frameshift mutation in ZMPSTE24 reveals utilization of alternative translation initiation codons. | Analysis of a non-lethal biallelic frameshift mutation in ZMPSTE24 reveals utilization of alternative translation initiation codons.
Kaufmann L, Pilic J, Auinger L, Mayer AL, Blatterer J, Semmler-Bruckner J, Abbas S, Rehman K, Ayaz M, Graier WF, Malli R, Petek E, Wagner K, Al Kaissi A, Khan MA, Windpassinger C. | 09/8/2023 |
| The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation. | The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation.
Shilagardi K, Spear ED, Abraham R, Griffin DE, Michaelis S., Free PMC Article | 11/5/2022 |
| An exceptional biallelic N-terminal frame shift mutation in ZMPSTE24 leads to non-lethal progeria due to possible utilization of a downstream alternative start codon. | An exceptional biallelic N-terminal frame shift mutation in ZMPSTE24 leads to non-lethal progeria due to possible utilization of a downstream alternative start codon.
Schaflinger E, Blatterer J, Khan AS, Kaufmann L, Auinger L, Tatrai B, Abbasi SW, Zeeshan Ali M, Abbasi AA, Al Kaissi A, Petek E, Wagner K, Ahmad Khan M, Windpassinger C. | 06/18/2022 |
| Restrictive dermopathy: Three new patients with ZMPSTE24 mutations and a review of the literature. | Restrictive dermopathy: Three new patients with ZMPSTE24 mutations and a review of the literature.
Scott JB, Yanes AF, Vivar KL, Yun D, Wagner A, Kruse L, Mancini AJ. | 12/25/2021 |
| ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1. | ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1.
Han M, Pandey D., Free PMC Article | 09/18/2021 |
| Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24. | Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.
Babatz TD, Spear ED, Xu W, Sun OL, Nie L, Carpenter EP, Michaelis S., Free PMC Article | 08/21/2021 |
| Protein structural and mechanistic basis of progeroid laminopathies. | Protein structural and mechanistic basis of progeroid laminopathies.
Marcelot A, Worman HJ, Zinn-Justin S. | 07/24/2021 |
| ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA. | ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.
Messner M, Ghadge SK, Maurer T, Graber M, Staggl S, Christine Maier S, Pölzl G, Zaruba MM., Free PMC Article | 04/17/2021 |
| OMA1-An integral membrane protease? | OMA1-An integral membrane protease?
Alavi MV., Free PMC Article | 04/17/2021 |
| Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology. | Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology.
Goblirsch BR, Wiener MC., Free PMC Article | 02/2/2021 |
| The tripartite architecture of the eukaryotic integral membrane protein zinc metalloprotease Ste24. | The tripartite architecture of the eukaryotic integral membrane protein zinc metalloprotease Ste24.
Goblirsch BR, Pryor EE Jr, Wiener MC., Free PMC Article | 01/9/2021 |
| Together these systems offer powerful methodology to study ZMPSTE24 disease alleles and to dissect the specific residues and features of the lamin A tail that are required for recognition and cleavage by the ZMPSTE24 protease. | A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24.
Spear ED, Alford RF, Babatz TD, Wood KM, Mossberg OW, Odinammadu K, Shilagardi K, Gray JJ, Michaelis S., Free PMC Article | 11/23/2019 |
| ZMPSTE24-dependent cleavage of prelamin A and the eight known disease-associated ZMPSTE24 missense mutations, were examined. | ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.
Spear ED, Hsu ET, Nie L, Carpenter EP, Hrycyna CA, Michaelis S., Free PMC Article | 12/22/2018 |
| ZMPSTE24 is a downstream effector of IFITM3 and is important for interferon-induced transmembrane antiviral activity. | ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Li S, Fu B, Wang L, Dorf ME., Free PMC Article | 09/23/2017 |
| ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses. | ZMPSTE24 defends against influenza and other pathogenic viruses.
Fu B, Wang L, Li S, Dorf ME., Free PMC Article | 08/19/2017 |
| This case demonstrates that accumulation of prelamin A, independent of the loss of function of ZMPSTE24 metallopeptidase that catalyzes processing of prelamin A, can cause a progeroid disorder and that a cell biology assay could be used in precision medicine to identify a potential therapy. | A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.
Wang Y, Lichter-Konecki U, Anyane-Yeboa K, Shaw JE, Lu JT, Östlund C, Shin JY, Clark LN, Gundersen GG, Nagy PL, Worman HJ., Free PMC Article | 08/5/2017 |
| used a fluorogenic assay of the activity of purified ZMPSTE24 to demonstrate that HIV protease inhibitors directly inhibit the human enzyme in a manner indicative of a competitive mechanism | Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors.
Clark KM, Jenkins JL, Fedoriw N, Dumont ME., Free PMC Article | 07/15/2017 |
| the present study suggests that inhibition of ZMPSTE24 by both mutational and expressional pathways might together play a role in tumorigenesis of colorectal cancer and gastric cancer harboring microsatellite instability phenotype. | Mutational and expressional alterations of ZMPSTE24, DNA damage response-related gene, in gastric and colorectal cancers.
Lee JH, Yoo NJ, Kim MS, An CH, Lee SH. | 03/25/2017 |
| results establish that the substrate profile of Ste24p is broader than anticipated, being more similar to that of the M16A protease family than that of the Rce1p CAAX protease with which it has been functionally associated | Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.
Hildebrandt ER, Arachea BT, Wiener MC, Schmidt WK., Free PMC Article | 12/24/2016 |
| ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA mutations or PI treatments that could translate in early atherosclerosis at the clinical level. | LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation.
Afonso P, Auclair M, Boccara F, Vantyghem MC, Katlama C, Capeau J, Vigouroux C, Caron-Debarle M. | 10/29/2016 |
| Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings. | Frame shift mutations of the ZMPSTE24 gene in two siblings with restrictive dermopathy.
Matulevičienė A, Meškienė R, Morkūnienė A, Ambrozaitytė L, Meškauskas R, Garunkštienė R, Drazdienė N, Utkus A, Kučinskas V. | 10/1/2016 |
| complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele. | New ZMPSTE24 (FACE1) mutations in patients affected with restrictive dermopathy or related progeroid syndromes and mutation update.
Navarro CL, Esteves-Vieira V, Courrier S, Boyer A, Duong Nguyen T, Huong le TT, Meinke P, Schröder W, Cormier-Daire V, Sznajer Y, Amor DJ, Lagerstedt K, Biervliet M, van den Akker PC, Cau P, Roll P, Lévy N, Badens C, Wehnert M, De Sandre-Giovannoli A., Free PMC Article | 04/4/2015 |
| miR-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells. | MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24.
Yu KR, Lee S, Jung JW, Hong IS, Kim HS, Seo Y, Shin TH, Kang KS. | 08/9/2014 |
| These data implicate copper as an important factor in promoting prostate cancer cell invasion and indicate that the selective posttranslational activation of ZMP-mediated protein shedding might play a role in this process. | Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signaling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells.
Parr-Sturgess CA, Tinker CL, Hart CA, Brown MD, Clarke NW, Parkin ET. | 04/27/2013 |