| Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) - Receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis. | Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) - Receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis.
Ogoshi M, Takahashi M, Aoyagi K, Ukena K, Aizawa S, Takeuchi H, Takahashi S, Takeuchi S. | 12/18/2021 |
| high RAMP3 expression is an independent prognostic factor of favorable overall survival and recurrence-free survival in patients with HCC and its expression might reduce the negative effect of TP53 mutation on survival. | RAMP3 is a prognostic indicator of liver cancer and might reduce the adverse effect of TP53 mutation on survival.
Fang A, Zhou S, Su X, Liu C, Chen X, Wan Y, Lei X, Xie L, Jia Y, Wang W, Yang L, Song X, Yao Y. | 04/6/2019 |
| interaction of RAMP2 or RAMP3 with CLR induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism. | Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
Watkins HA, Chakravarthy M, Abhayawardana RS, Gingell JJ, Garelja M, Pardamwar M, McElhinney JM, Lathbridge A, Constantine A, Harris PW, Yuen TY, Brimble MA, Barwell J, Poyner DR, Woolley MJ, Conner AC, Pioszak AA, Reynolds CA, Hay DL., Free PMC Article | 12/17/2016 |
| the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus | Expression and distribution of the adrenomedullin system in newborn human thymus.
De Martin S, Paliuri G, Belloni A, Orso G, Zanarella E, Stellin G, Milanesi O, Basso G, Ruga EM, Frasson C, Gabbia D, Perdoncin G, Palatini P, Bova S., Free PMC Article | 01/31/2015 |
| Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor) N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface. | Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
Watkins HA, Walker CS, Ly KN, Bailey RJ, Barwell J, Poyner DR, Hay DL., Free PMC Article | 10/11/2014 |
| The expression of RAMP3 is downregulated in the fetal lung with increasing gestational age. | Adrenomedullin expression in the developing human fetal lung.
Ramos CG, Sun X, Johnson EB, Nelson HE, Gonzalez Bosc LV. | 07/19/2014 |
| the RAMP3 TMD participates in the negative regulation of CLR/RAMP3 internalization. | Characterization of the single transmembrane domain of human receptor activity-modifying protein 3 in adrenomedullin receptor internalization.
Kuwasako K, Kitamura K, Nagata S, Nozaki N, Kato J. | 06/2/2012 |
| Data show that LOXL2 and RAMP3 are strongly coexpressed in human colon, breast, and gastric carcinomas but not in normal colon or gastric epithelial cells. | Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2.
Brekhman V, Lugassie J, Zaffryar-Eilot S, Sabo E, Kessler O, Smith V, Golding H, Neufeld G. | 03/12/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| This study provides insight into the role of three amino acid changes in human RAMP3. | Functional characterization of two human receptor activity-modifying protein 3 variants.
Bailey RJ, Bradley JW, Poyner DR, Rathbone DL, Hay DL. | 07/5/2010 |
| Morphological fluorescence techniques, bioluminescence resonance energy transfer, and bimolecular fluorescence complementation analysis demonstrate that the secretin receptor associates specifically with RAMP3, but not with RAMP1 or RAMP2. | Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor.
Harikumar KG, Simms J, Christopoulos G, Sexton PM, Miller LJ., Free PMC Article | 01/21/2010 |
| Data found that expressions of RAMP1, RAMP2 and RAMP3 mRNAs increased with the worsening of heart function, but the expressions of RAMP1 and RAMP2 mRNA decreased at level IV of heart failure. | [Increased atria expression of receptor activity-modifying proteins in heart failure patients].
Wang YF, Zhang J, Li J, Lan LQ, Yang ZM, Wang SR. | 01/21/2010 |
| Identification of RAMP3 residues for adrenomedjullin receptors are reported. | Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.
Qi T, Christopoulos G, Bailey RJ, Christopoulos A, Sexton PM, Hay DL. | 01/21/2010 |
| The His residues of hRAMP2 and -3 differentially govern adrenomedullin receptor function. | Functions of the extracellular histidine residues of receptor activity-modifying proteins vary within adrenomedullin receptors.
Kuwasako K, Kitamura K, Nagata S, Kato J. | 01/21/2010 |
| Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells | Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.
Aiyar N, Disa J, Pullen M, Nambi P. | 01/21/2010 |
| This study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for calcitonin receptor versus calcitonin receptor-like receptor-based receptors. | A critical role for the short intracellular C terminus in receptor activity-modifying protein function.
Udawela M, Christopoulos G, Morfis M, Christopoulos A, Ye S, Tilakaratne N, Sexton PM. | 01/21/2010 |
| Co-expression of calcitonin receptors (CT) lacking a portion of domain 1 with receptor activity-modifying protein (RAMP) 1, 2, or 3 appears to produce functional CT-(8-32)-sensitive adrenomedullin receptors. | Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Kuwasako K, Kitamura K, Nagoshi Y, Eto T. | 01/21/2010 |
| results, using both endogenous and overexpressed cellular models, indicate a novel function for NHERF-1 and RAMP3 in the internalization of the adrenomedullin receptor and suggest additional regulatory mechanisms for receptor trafficking | Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1.
Bomberger JM, Spielman WS, Hall CS, Weinman EJ, Parameswaran N. | 01/21/2010 |
| results show the presence of calcitonin receptor-like receptor and receptor activity-modifying proteins in middle meningeal, middle cerebral, pial, and superficial temporal vessels | Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.
Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. | 01/21/2010 |
| the respective C-tails of hRAMP2 and -3 differentially affect hCRLR surface delivery and internalization | Functions of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and adrenomedullin receptors.
Kuwasako K, Cao YN, Chu CP, Iwatsubo S, Eto T, Kitamura K. | 01/21/2010 |
| RAMP3 interacts with N-ethylmaleimide-sensitive factor to cause the change in trafficking | Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.
Bomberger JM, Parameswaran N, Hall CS, Aiyar N, Spielman WS. | 01/21/2010 |