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    ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) [ Homo sapiens (human) ]

    Gene ID: 10257, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.

    ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
    Ranjit S, Wang Y, Zhu J, Cheepala SB, Schuetz EG, Cho WJ, Xu B, Robinson CG, Wu G, Naren AP, Schuetz JD.,

    01/10/2024
    Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.

    Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
    Bloch M, Raj I, Pape T, Taylor NMI.

    11/10/2023
    m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.

    m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.
    Huang C, Xu R, Zhu X, Jiang H.

    10/28/2023
    Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets.

    Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets.
    Wolf R, Grammbauer S, Palankar R, Tolksdorf C, Moritz E, Böhm A, Hasan M, Hafkemeyer A, Greinacher A, Tzvetkov MV, Rauch BH, Jedlitschky G., Free PMC Article

    09/17/2022
    Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON).

    Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON).
    Matsumoto H, Sasai H, Kawamoto N, Katsuyama M, Minamiyama M, Kuru S, Fukao T, Ohnishi H, SMON research group members., Free PMC Article

    07/30/2022
    Drug resistance biomarker ABCC4 of selinexor and immune feature in multiple myeloma.

    Drug resistance biomarker ABCC4 of selinexor and immune feature in multiple myeloma.
    Hu F, Chen XQ, Li XP, Lu YX, Chen SL, Wang DW, Liang Y, Dai YJ.

    06/25/2022
    IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.

    IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
    Huo J, Fu L, Jin M, Li Z, Zhang M.

    05/21/2022
    ABCC4 single-nucleotide polymorphisms as markers of tenofovir disoproxil fumarate-induced kidney impairment.

    ABCC4 single-nucleotide polymorphisms as markers of tenofovir disoproxil fumarate-induced kidney impairment.
    Cheli S, Baldelli S, De Silvestri A, Fusi M, Minisci D, Gervasoni C, Cattaneo D, Clementi E, Meraviglia P, Montrasio C.

    05/14/2022
    In-vitro characterization of coding variants with predicted functional implications in the efflux transporter multidrug resistance protein 4 (MRP4, ABCC4).

    In-vitro characterization of coding variants with predicted functional implications in the efflux transporter multidrug resistance protein 4 (MRP4, ABCC4).
    Mailloux J, Medwid S, Facey A, Sung I, Russell LE, Tirona RG, Kim RB, Schwarz UI.

    04/9/2022
    The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate.

    The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate.
    Furtado A, Mineiro R, Duarte AC, Gonçalves I, Santos CR, Quintela T., Free PMC Article

    04/2/2022
    Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.

    Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
    Belleville-Rolland T, Leuci A, Mansour A, Decouture B, Martin F, Poirault-Chassac S, Rouaud M, Guerineau H, Dizier B, Pidard D, Gaussem P, Bachelot-Loza C.

    03/19/2022
    Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene.

    Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene.
    Zobeck MC, Bernhardt MB, Kamdar KY, Rabin KR, Lupo PJ, Scheurer ME., Free PMC Article

    03/12/2022
    Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population.

    Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population.
    Monte N, Pantoja KBCC, Rodrigues JCG, de Carvalho DC, Azevedo TCB, Pereira EEB, de Assumpção PP, Dos Santos SEB, Fernandes MR, Dos Santos NPC., Free PMC Article

    03/5/2022
    Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

    Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.
    Fernandes MR, Rodrigues JCG, Dobbin EAF, Pastana LF, da Costa DF, Barra WF, Modesto AAC, de Assumpção PB, da Costa Silva AL, Dos Santos SEB, Burbano RMR, de Assumpção PP, Dos Santos NPC.

    01/8/2022
    Multidrug Resistance Protein 4 (MRP4/ABCC4): A Suspected Efflux Transporter for Human's Platelet Activation.

    Multidrug Resistance Protein 4 (MRP4/ABCC4): A Suspected Efflux Transporter for Human's Platelet Activation.
    Angelis I, Moussis V, Tsoukatos DC, Tsikaris V.

    12/25/2021
    Circular RNA circABCC4 acts as a ceRNA of miR-154-5p to improve cell viability, migration and invasion of breast cancer cells in vitro.

    Circular RNA circABCC4 acts as a ceRNA of miR-154-5p to improve cell viability, migration and invasion of breast cancer cells in vitro.
    Jiang J, Cheng X., Free PMC Article

    12/11/2021
    Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR-3186-3p/TNRC6B axis.

    Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR-3186-3p/TNRC6B axis.
    Liu M, Wang P, Sui X, Ding F, Liu L, Gao Z, Cheng Z.

    07/17/2021
    MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.

    MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.
    Rodríguez González A, Sahores A, Díaz-Nebreda A, Yaneff A, Di Siervi N, Gómez N, Monczor F, Fernández N, Davio C, Shayo C.

    06/19/2021
    ATP-Binding Cassette Transporter C4 is a Prostaglandin D2 Exporter in HMC-1 cells.

    ATP-Binding Cassette Transporter C4 is a Prostaglandin D2 Exporter in HMC-1 cells.
    Tanaka N, Kawai J, Hirasawa N, Mano N, Yamaguchi H.

    06/5/2021
    ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer.

    ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer.
    Jung M, Gao J, Cheung L, Bongers A, Somers K, Clifton M, Ramsay EE, Russell AJ, Valli E, Gifford AJ, George J, Kennedy CJ, Wakefield MJ, Topp M, Ho GY, Australian Ovarian Cancer Study, Scott CL, Bowtell DD, deFazio A, Norris MD, Haber M, Henderson MJ.

    04/17/2021
    Multidrug resistance protein 4 (MRP4/ABCC4) is overexpressed in clear cell renal cell carcinoma (ccRCC) and is essential to regulate cell proliferation.

    Multidrug resistance protein 4 (MRP4/ABCC4) is overexpressed in clear cell renal cell carcinoma (ccRCC) and is essential to regulate cell proliferation.
    Colavita JPM, Todaro JS, de Sousa M, May M, Gómez N, Yaneff A, Di Siervi N, Aguirre MV, Guijas C, Ferrini L, Davio C, Rodríguez JP.

    03/27/2021
    Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness.

    Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness.
    Sahores A, Carozzo A, May M, Gómez N, Di Siervi N, De Sousa Serro M, Yaneff A, Rodríguez-González A, Abba M, Shayo C, Davio C., Free PMC Article

    03/6/2021
    Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.

    Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.
    Low FG, Shabir K, Brown JE, Bill RM, Rothnie AJ., Free PMC Article

    02/27/2021
    An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.

    An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
    Wijaya J, Vo BT, Liu J, Xu B, Wu G, Wang Y, Peng J, Zhang J, Janke LJ, Orr BA, Yu J, Roussel MF, Schuetz JD., Free PMC Article

    10/24/2020
    MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer.

    MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer.
    Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, Sun X, Chen H, Duan YG, Jiang X, Wong MP, Chan HC, Zou F, Ruan YC., Free PMC Article

    08/22/2020
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