| glycerolipid synthesis is induced during macrophage activation. GPAT4 protein level and GPAT3/GPAT4 enzymatic activity increase during this process, and these two isoforms were required for the accumulation of cell TAG and PL. | Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages.
Quiroga IY, Pellon-Maison M, Suchanek AL, Coleman RA, Gonzalez-Baro MR. | 09/7/2019 |
| These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT. | SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase.
Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA, Yang H., Free PMC Article | 11/26/2017 |
| GPAT4 limits excessive fatty acid oxidation and the detrimental induction of a hypermetabolic state | Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes.
Cooper DE, Grevengoed TJ, Klett EL, Coleman RA., Free PMC Article | 09/12/2015 |
| Data (from studies in knockout mice) suggest GPAT4-derived phosphatidic acid impairs insulin signaling in liver/contributes to insulin resistance via interaction of mTOR (mechanistic target of rapamycin)/Rictor (RPTOR independent companion of mTOR). | Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.
Zhang C, Cooper DE, Grevengoed TJ, Li LO, Klett EL, Eaton JM, Harris TE, Coleman RA., Free PMC Article | 09/27/2014 |
| GPAT1, but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation. | Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.
Wendel AA, Cooper DE, Ilkayeva OR, Muoio DM, Coleman RA., Free PMC Article | 11/30/2013 |
| Glycerol-3-phosphate acyltransferase 4 might play an important role in spermatogenesis, especially in mid-meiosis.[Glycerol-3-phosphate acyltransferase 4] | Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis.
Qiu Q, Liu G, Li W, Shi Q, Zhu F, Lu G. | 04/1/2011 |
| "Agpat6(-/-) mice" are actually deficient in a novel NEM-sensitive sn-Glycerol-3-phosphate acyltransferase (GPAT), GPAT4 | Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.
Nagle CA, Vergnes L, Dejong H, Wang S, Lewin TM, Reue K, Coleman RA., Free PMC Article | 01/21/2010 |
| AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4. | AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G., Free PMC Article | 01/21/2010 |
| Results identify a novel glycerolipid acyltransferase of the endoplasmic reticulum, AGPAT6, which is crucial for the production of milk fat by the mammary gland. | Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.
Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG., Free PMC Article | 01/21/2010 |
| Results show that Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family. | Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity.
Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG, Reue K., Free PMC Article | 01/21/2010 |
| Expression in testis increased steadily with spermatogenesis & sexual maturation. It may play an important role in spermatogenesis & development of cryptorchid testes, & is testis-specific apoptosis candidate oncogene | Molecular cloning of a novel mouse testis-specific spermatogenic cell apoptosis inhibitor gene mTSARG7 as a candidate oncogene.
Tan XJ, Xing XW, Li LY, Wu ZD, Zhong CG, Nie DS, Fu JJ, Xiang Y, Deng Y, Lu GX. | 01/21/2010 |