| Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis. | Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.
Wu X, Zeng Z, Peng K, Ren D, Zhang L. | 06/23/2023 |
| Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma. | Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.
Ryu TY, Lee J, Kang Y, Son MY, Kim DS, Lee YS, Kim MY, Cho HS. | 05/23/2023 |
| DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKalpha to disrupt choline metabolism. | DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
Li Z, Tan Y, Li X, Quan J, Bode AM, Cao Y, Luo X., Free PMC Article | 10/8/2022 |
| LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells | LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells.
Sırma Ekmekci S, Emrence Z, Abacı N, Sarıman M, Salman B, Ekmekci CG, Güleç Ç., Free PMC Article | 07/31/2021 |
| Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer. | Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
Han Y, Wang Z, Sun S, Zhang Z, Liu J, Jin X, Wu P, Ji T, Ding W, Wang B, Gao Q., Free PMC Article | 04/24/2021 |
| DHRS2 is dispensable for up-regulation of romidepsin effectors. | Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.
Nettersheim D, Berger D, Jostes S, Skowron M, Schorle H., Free PMC Article | 04/18/2020 |
| Results show that DHRS2 is highly expressed in oxaliplatin-resistant colorectal cancer (CRC) cell line. Furthermore, DHRS2 regulates ERCC1 to promote oxaliplatin resistance through a p53dependent pathway, and mediates EMT by suppressing Ecadherin expression. | Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ., Free PMC Article | 03/28/2020 |
| Our report suggests that activating DHRS2 to reprogram lipid homeostasis may be a target for the development of targeted therapies against NPC. | DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma.
Luo X, Li N, Zhao X, Liao C, Ye R, Cheng C, Xu Z, Quan J, Liu J, Cao Y., Free PMC Article | 12/21/2019 |
| Among these targets, dehydrogenase/reductase member 2 DHRS2 and MYO1B were directly regulated by miR1453p in esophageal squamous cell carcinoma (ESCC) cells by dual luciferase reporter assays. Aberrantly expressed DHRS2 and MYOIB were detected in ESCC clinical specimens, and their overexpression enhanced cancer cell aggressiveness. | Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation.
Shimonosono M, Idichi T, Seki N, Yamada Y, Arai T, Arigami T, Sasaki K, Omoto I, Uchikado Y, Kita Y, Kurahara H, Maemura K, Natsugoe S. | 04/6/2019 |
| Low DHRS2 expression promotes esophageal squamous cell carcinoma. | DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma.
Zhou Y, Wang L, Ban X, Zeng T, Zhu Y, Li M, Guan XY, Li Y., Free PMC Article | 03/9/2019 |
| Homeobox A13 (HOXA13) played a role of carcinogenesis through directly down-regulating dehydrogenase/reductase 2 (DHRS2) to increase proto-oncogene proteins c-mdm2 (MDM2). | HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5-FU resistance by a p53-dependent pathway.
Han Y, Song C, Wang J, Tang H, Peng Z, Lu S. | 03/2/2019 |
| DHRS2 and DHRS4 genes are syntenic outparalogues originating from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade | Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
Gabrielli F, Tofanelli S, Gabrielli F, Tofanelli S. | 02/28/2013 |
| A rapid divergent evolution brought the human DHRS2 gene, duplicated form of the DHRS4 one, to code a SDR enzyme having subcellular localization, synthesis regulation and specialized cellular functions very different from those of the human DHRS4 enzyme. | Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
Gabrielli F, Tofanelli S, Gabrielli F, Tofanelli S. | 11/8/2012 |
| Complete genomic organization of DHRS2, including two alternative promoter regions: a hepatocyte-specific promoter and a monocyte-derived dendritic cell-specific promoter | Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells.
Heinz S, Krause SW, Gabrielli F, Wagner HM, Andreesen R, Rehli M. | 12/19/2011 |
| c-Myb proto-oncogene has a tumor suppressor role in breast cancer via c-Myb controlled DHRS2 (HEP27) expression. | Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer.
Thorner AR, Parker JS, Hoadley KA, Perou CM., Free PMC Article | 12/9/2011 |
| Hep27 is regulated at the transcriptional level by the proto-oncogene c-Myb and is required for c-Myb-induced p53 stabilization. | Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
Deisenroth C, Thorner AR, Enomoto T, Perou CM, Zhang Y., Free PMC Article | 08/23/2010 |
| Molecular cloning, sequence and Chr 14 localization of the DHRS2 gene. Nuclear and cytoplasmic localization and normal tissue distribution of the DHRS2-encoded Hep27 protein. | A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product.
Pellegrini S, Censini S, Guidotti S, Iacopetti P, Rocchi M, Bianchi M, Covacci A, Gabrielli F. | 01/31/2010 |
| The synthesis of the nuclear protein D (Hep27 protein old name) is up-regulated in growth-inhibited HepG2 cells and is inhibited during DNA synthesis. | Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells.
Donadel G, Garzelli C, Frank R, Gabrielli F. | 01/20/2010 |
| In human endometrial carcinoma cells, the Hep27 protein encoded by DHRS2 is specifically upregulated in mitochondria by the ERM/ETV5 transcription factor and Hep27 has a protective role against apoptosis induced by oxidative stress. | Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.
Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M. | 09/14/2009 |
| Hep27 a cell-cycle regulated protein belongs to the SDR family (short-chain dehydrogenase/reductase family). | A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family.
Gabrielli F, Donadel G, Bensi G, Heguy A, Melli M. | 07/27/2007 |
| Hep27 is a NADPH-dependent dicarbonyl reductase enzyme active on xenobiotics. | Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.
Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jörnvall H, Oppermann U., Free PMC Article | 07/26/2007 |