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    ATP6AP2 ATPase H+ transporting accessory protein 2 [ Homo sapiens (human) ]

    Gene ID: 10159, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Human V-ATPase function is positively and negatively regulated by TLDc proteins.

    Human V-ATPase function is positively and negatively regulated by TLDc proteins.
    Oot RA, Wilkens S.,

    08/1/2024
    Targeting the (pro)renin receptor in cancers: from signaling to pathophysiological effects.

    Targeting the (pro)renin receptor in cancers: from signaling to pathophysiological effects.
    Ouyang X, Xu C.

    04/27/2023
    Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct.

    Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct.
    Lara LS, Gonzalez AA, Hennrikus MT, Prieto MC., Free PMC Article

    12/24/2022
    The Role of (Pro)Renin Receptor in the Metabolic Syndrome.

    The Role of (Pro)Renin Receptor in the Metabolic Syndrome.
    Nichols K, Yiannikouris F.

    12/24/2022
    (Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System.

    (Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System.
    Souza LAC, Earley YF., Free PMC Article

    12/24/2022
    Role of the prorenin receptor in endometrial cancer cell growth.

    Role of the prorenin receptor in endometrial cancer cell growth.
    Martin JH, Mohammed R, Delforce SJ, Skerrett-Byrne DA, de Meaultsart CC, Almazi JG, Stephens AN, Verrills NM, Dimitriadis E, Wang Y, Lumbers ER, Pringle KG., Free PMC Article

    10/1/2022
    Reduced gene dosage is a common mechanism of neuropathologies caused by ATP6AP2 splicing mutations.

    Reduced gene dosage is a common mechanism of neuropathologies caused by ATP6AP2 splicing mutations.
    Edelman WC, Kiianitsa K, Virmani T, Martinez RA, Young JE, Keene CD, Bird TD, Raskind WH, Korvatska O., Free PMC Article

    08/27/2022
    (Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-beta1/SMAD3 Pathway.

    (Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway.
    Hsieh YC, Lee KC, Lei HJ, Lan KH, Huo TI, Lin YT, Chan CC, Schnabl B, Huang YH, Hou MC, Lin HC., Free PMC Article

    03/26/2022
    The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma.

    The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma.
    Morosin SK, Delforce SJ, Kahl RGS, Corbisier de Meaultsart C, Lumbers ER, Pringle KG.

    03/19/2022
    Functions of the (pro)renin receptor (Atp6ap2) at molecular and system levels: pathological implications in hypertension, renal and brain development, inflammation, and fibrosis.

    Functions of the (pro)renin receptor (Atp6ap2) at molecular and system levels: pathological implications in hypertension, renal and brain development, inflammation, and fibrosis.
    Hoffmann N, Peters J.

    02/26/2022
    Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na(+)-Cl(-) Cotransporter) Activity.

    Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na(+)-Cl(-) Cotransporter) Activity.
    Xu C, Chen Y, Wang F, Xie S, Yang T., Free PMC Article

    01/15/2022
    Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.

    Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
    Ohwaki A, Nishizawa H, Kato A, Yoshizawa H, Miyazaki J, Noda Y, Sakabe Y, Sekiya T, Fujii T, Kurahashi H.

    01/1/2022
    Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans.

    Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans.
    Sasaki N, Morimoto S, Suda C, Shimizu S, Ichihara A., Free PMC Article

    11/6/2021
    Cleavage of the soluble (pro)renin receptor (sATP6AP2) in the placenta.

    Cleavage of the soluble (pro)renin receptor (sATP6AP2) in the placenta.
    Morosin SK, Delforce SJ, Lumbers ER, Pringle KG.

    10/23/2021
    Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population.

    Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population.
    Akther J, Das A, Rahman MA, Saha SK, Hosen MI, Ebihara A, Nakagawa T, Suzuki F, Nabi AHMN.

    10/2/2021
    (Pro)renin receptor/ATP6AP2 is required for autophagy and regulates proliferation in lung adenocarcinoma cells.

    (Pro)renin receptor/ATP6AP2 is required for autophagy and regulates proliferation in lung adenocarcinoma cells.
    Ohba K, Endo M, Sato S, Kashio-Yokota Y, Hirose T, Takahashi K.

    07/10/2021
    The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers.

    The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers.
    Wang J, Nishiyama A, Matsuyama M, Wang Z, Yuan Y., Free PMC Article

    07/10/2021
    The (pro)renin receptor (ATP6AP2) does not play a role in syncytialisation of term human primary trophoblast cells.

    The (pro)renin receptor (ATP6AP2) does not play a role in syncytialisation of term human primary trophoblast cells.
    Morosin SK, Delforce SJ, Lumbers ER, Pringle KG.

    07/3/2021
    Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H.

    Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H.
    Shibayama Y, Takahashi K, Yamaguchi H, Yasuda J, Yamazaki D, Rahman A, Fujimori T, Fujisawa Y, Takai S, Furukawa T, Nakagawa T, Ohsaki H, Kobara H, Wong JH, Masaki T, Yuzawa Y, Kiyomoto H, Yachida S, Fujimoto A, Nishiyama A., Free PMC Article

    06/26/2021
    Soluble (pro)renin receptor in elderly chronic heart failure patients.

    Soluble (pro)renin receptor in elderly chronic heart failure patients.
    Obradovic D, Loncar G, Radenovic S, Tahirovic E, Heidecke H, Schulze-Forster K, Muller D, Busjahn A, Buttner P, Veskovic J, Zdravkovic M, Li H, Li S, Savkovic V, Pieske B, Dungen HD, Dechend R.

    06/12/2021
    (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability.

    (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability.
    Gianzo M, Urizar-Arenaza I, Muñoa-Hoyos I, Larreategui Z, Garrido N, Irazusta J, Subirán N., Free PMC Article

    05/1/2021
    Soluble (pro)renin receptor increased by hypoxia maintains oxidative metabolism in trophoblasts.

    Soluble (pro)renin receptor increased by hypoxia maintains oxidative metabolism in trophoblasts.
    Suda C, Yatabe J, Yatabe M, Yarita M, Ichihara A.

    04/13/2021
    The Yes-associated protein (YAP) signaling, which is coordinately regulated by Wnt/beta-catenin, contributed to the development of (P)RR-induced sarcopenia.

    (Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis.
    Yoshida N, Endo J, Kinouchi K, Kitakata H, Moriyama H, Kataoka M, Yamamoto T, Shirakawa K, Morimoto S, Nishiyama A, Hashiguchi A, Higuchi I, Fukuda K, Ichihara A, Sano M., Free PMC Article

    09/26/2020
    Association between serum soluble (pro)renin receptor level and worsening of cardiac function in hemodialysis patients: A prospective observational study.

    Association between serum soluble (pro)renin receptor level and worsening of cardiac function in hemodialysis patients: A prospective observational study.
    Amari Y, Morimoto S, Iida T, Takimoto H, Okuda H, Yurugi T, Oyama Y, Aoyama N, Nakajima F, Ichihara A., Free PMC Article

    08/15/2020
    PRR has a role in renin-induced increased proliferation of infantile hemangioma cells through the Wnt signaling pathway

    Expression of (pro)renin receptor and its effect on endothelial cell proliferation in infantile hemangioma.
    van Schaijik B, Tan ST, Marsh RW, Itinteang T.

    07/11/2020
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