| Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke. | Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke.
Connelly JA, Zhang X, Chen Y, Chao Y, Shi Y, Jacob TC, Wang QJ., Free PMC Article | 02/5/2024 |
| Loss of Protein Kinase D2 Activity Protects Against Bleomycin-Induced Dermal Fibrosis in Mice. | Loss of Protein Kinase D2 Activity Protects Against Bleomycin-Induced Dermal Fibrosis in Mice.
Chen L, Zhao J, Chao Y, Roy A, Guo W, Qian J, Xu W, Domsic RT, Lafyatis R, Lu B, Deng F, Wang QJ., Free PMC Article | 04/14/2023 |
| Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line. | Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line.
Jiao Y, Williams A, Wei N. | 10/22/2022 |
| Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity. | Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.
Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G., Free PMC Article | 10/30/2021 |
| Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells. | Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
Zhu Z, Zhang Y, Wang X, Wang X, Ye SD. | 03/27/2021 |
| Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. | Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B., Free PMC Article | 10/10/2020 |
| The results indicate that down-regulation of PRKD2 is involved in the pathogenesis of hyperinsulinemia which, in turn, results in insulin resistance and metabolic disorders. | Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.
Xiao Y, Wang C, Chen JY, Lu F, Wang J, Hou N, Hu X, Zeng F, Ma D, Sun X, Ding Y, Zhang Y, Zheng W, Liu Y, Shang H, Zhu W, Han C, Zhang Y, Ouyang K, Chen L, Chen J, Xiao RP, Li CY, Zhang X., Free PMC Article | 12/22/2018 |
| Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic. | Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.
Mazzeo C, Calvo V, Alonso R, Mérida I, Izquierdo M., Free PMC Article | 09/10/2016 |
| Results reveal that whereas protein kinase D1 and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins. | Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity.
Avriyanti E, Atik N, Kunii M, Furumoto N, Iwano T, Yoshimura S, Harada R, Harada A. | 01/23/2016 |
| PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8(+) T cells that became effector cells. | Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8⁺ T cells.
Navarro MN, Feijoo-Carnero C, Arandilla AG, Trost M, Cantrell DA., Free PMC Article | 07/4/2015 |
| Protein kinase D2 promotes in vitro osteoclast differentiation and fusion | Protein kinase D promotes in vitro osteoclast differentiation and fusion.
Mansky KC, Jensen ED, Davidova J, Yamamoto M, Gopalakrishnan R., Free PMC Article | 06/1/2013 |
| A bioinformatic screen identified the serine-threonine kinase protein kinase D2 (PRKD2) as a potential effector of GABP in hematopoietic stem cells | GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.
Yang ZF, Zhang H, Ma L, Peng C, Chen Y, Wang J, Green MR, Li S, Rosmarin AG., Free PMC Article | 04/13/2013 |
| Transcriptional profiling reveals the full consequences of PKD2 loss and maps in detail the selective, but critical, function for PKD2 in signalling by alpha/beta mature TCR complexes in peripheral T-cells. | Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
Navarro MN, Sinclair LV, Feijoo-Carnero C, Clarke R, Matthews SA, Cantrell DA., Free PMC Article | 06/23/2012 |
| PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC isoforms, in particular, PKCdelta activate PKD2 in platelets. | Protein kinase Cδ mediates the activation of protein kinase D2 in platelets.
Bhavanasi D, Kim S, Goldfinger LE, Kunapuli SP., Free PMC Article | 10/22/2011 |
| Data demonstrate that, unlike PKD1, PKD2 catalytic activity is dispensable for normal embryogenesis. | Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.
Matthews SA, Navarro MN, Sinclair LV, Emslie E, Feijoo-Carnero C, Cantrell DA., Free PMC Article | 12/11/2010 |
| PKD2, like PKD, facilitates mitogenesis in 3T3 cells | Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cells.
Sinnett-Smith J, Zhukova E, Rey O, Rozengurt E. | 01/21/2010 |