| SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4. | SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y., Free PMC Article | 02/4/2023 |
| SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells. | SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.
Liu Y, Liu J, Kong X, Li H, Shao J, Jiang Z. | 02/6/2021 |
| Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells. | Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.
Ranzuglia V, Lorenzon I, Pellarin I, Sonego M, Dall'Acqua A, D'Andrea S, Lovisa S, Segatto I, Coan M, Polesel J, Serraino D, Sabatelli P, Spessotto P, Belletti B, Baldassarre G, Schiappacassi M., Free PMC Article | 12/12/2020 |
| SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation. | SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
Liu Y, Chen JB, Zhang M, Zhang XL, Meng JL, Zhou J, Hao ZY, Zhang L, Zu XB, Liang CZ. | 08/15/2020 |
| Loss of the paternally derived allele of the imprinted SGK2 gene is associated with Shwachman-Diamond syndrome. | Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.
Nacci L, Valli R, Maria Pinto R, Zecca M, Cipolli M, Morini J, Cesaro S, Boveri E, Rosti V, Corti P, Ambroni M, Pasquali F, Danesino C, Maserati E, Minelli A. | 07/22/2017 |
| These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/beta-catenin signaling in hepatocellular carcinoma cells. | SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.
Liu J, Zhang G, Lv Y, Zhang X, Ying C, Yang S, Kong X, Yu Y. | 07/15/2017 |
| SGK2 stimulated hOAT4 transport activity by abrogating the inhibitory effect of Nedd4-2 on the transporter. | Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.
Wang H, Xu D, Toh MF, Pao AC, You G., Free PMC Article | 07/2/2016 |
| Activation of hepatocyte pregnane X receptor is mediated through serum- and glucocorticoid-regulated kinase (SGK)2. | Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.
Gotoh S, Negishi M., Free PMC Article | 02/15/2014 |
| Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo. | The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.
Böhmer C, Sopjani M, Klaus F, Lindner R, Laufer J, Jeyaraj S, Lang F, Palmada M. | 09/27/2010 |
| All three members of the SGK family of kinases SGK1-3 and protein kinase B stimulate the slowly activating K(+) channel KCNE1/KCNQ1. The kinases may thus participate in the regulation of KCNE1-dependent transport and excitability. | Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.
Embark HM, Böhmer C, Vallon V, Luft F, Lang F. | 01/21/2010 |
| Powerful stimulating effect of all three isoforms of SGK on K(+) channels. Those effects may participate in regulation of epithelial transport, cell proliferation, and neuromuscular excitability. | K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.
Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F. | 01/21/2010 |
| Co-expression of SGK1, but not of SGK2 or SGK3, increased Kv 4.3/KChIP2b channel currents. | Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes.
Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G. | 01/21/2010 |