| Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay. | Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay.
Hao P, Qu Q, Pang Z, Li L, Du S, Shang L, Jin C, Xu W, Ha Z, Jiang Y, Chen J, Gao Z, Jin N, Wang J, Li C., Free PMC Article | 01/3/2024 |
| Transition State of Arp2/3 Complex Activation by Actin-Bound Dimeric Nucleation-Promoting Factor. | Transition State of Arp2/3 Complex Activation by Actin-Bound Dimeric Nucleation-Promoting Factor.
van Eeuwen T, Boczkowska M, Rebowski G, Carman PJ, Fregoso FE, Dominguez R., Free PMC Article | 10/16/2023 |
| ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells. | ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.
Sadhu L, Tsopoulidis N, Hasanuzzaman M, Laketa V, Way M, Fackler OT., Free PMC Article | 05/17/2023 |
| A familial 2p14 microdeletion disrupting actin-related protein 2 and Ras-related protein Rab-1A genes with intellectual disability and language impairment. | A familial 2p14 microdeletion disrupting actin-related protein 2 and Ras-related protein Rab-1A genes with intellectual disability and language impairment.
Tabata K, Ishiyama A, Nakamura Y, Sasaki M, Inoue K, Goto YI. | 04/16/2022 |
| Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma. | Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma.
Zhang L, Zhang Y, Lei Y, Wei Z, Li Y, Wang Y, Bu Y, Zhang C., Free PMC Article | 12/19/2020 |
| Overall, the authors demonstrate the active role of the Arp2/3 complex and WIPF2 in mediating the internalization of Aspergillus fumigatus conidia into human airway epithelial cells. | Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.
Culibrk L, Croft CA, Toor A, Yang SJ, Singhera GK, Dorscheid DR, Moore MM, Tebbutt SJ., Free PMC Article | 12/7/2019 |
| Proteins involved in actin-filament-based processes, specifically CDC42 and members of the ARP2/3 complex are crucial for establishment of Japanese encephalitis virus infection. | Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.
Khasa R, Vaidya A, Vrati S, Kalia M. | 10/26/2019 |
| we show that drebrin and hCDC14A regulate the recruitment of the actin organizer Arp2 to centrosomes. In addition, during ciliogenesis hCDC14A also regulates endocytosis and targeting of myosin Va vesicles to the basal body in a drebrin-independent manner, indicating that it impacts primary cilia formation in a multilayered manner. | The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.
Uddin B, Partscht P, Chen NP, Neuner A, Weiß M, Hardt R, Jafarpour A, Heßling B, Ruppert T, Lorenz H, Pereira G, Schiebel E., Free PMC Article | 08/17/2019 |
| Collectively, our results demonstrate that palladin can functionally replace the Arp2/3 complex during bacterial actin-based cellular entry and intracellular motility of Listeria monocytogenes. | Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections.
Dhanda AS, Vogl AW, Albraiki SE, Otey CA, Beck MR, Guttman JA., Free PMC Article | 01/12/2019 |
| RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway | Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets.
Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz H., Free PMC Article | 01/6/2018 |
| We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects. | Clinical and molecular cytogenetic characterization of four unrelated patients carrying 2p14 microdeletions.
Mathieu ML, Demily C, Chantot-Bastaraud S, Afenjar A, Mignot C, Andrieux J, Gerard M, Catala-Mora J, Jouk PS, Labalme A, Edery P, Sanlaville D, Rossi M. | 12/2/2017 |
| evidence of a direct protein-protein interaction between PKD2 and Arp2/3 | Protein Interaction Network of Human Protein Kinase D2 Revealed by Chemical Cross-Linking/Mass Spectrometry.
Häupl B, Ihling CH, Sinz A. | 11/4/2017 |
| miR-24-1*/let-7a*-ARP2/3 complex-RAC isoforms pathway may represent a novel pathogenic mechanism for Hirschsprung disease. | Suppressive action of miRNAs to ARP2/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease.
Tang W, Cai P, Huo W, Li H, Tang J, Zhu D, Xie H, Chen P, Hang B, Wang S, Xia Y., Free PMC Article | 07/1/2017 |
| this study identified roles for ARP2 and filopodia in human respiratory syncytial virus -induced cell motility, virus production, and cell-to-cell spread. | Actin-Related Protein 2 (ARP2) and Virus-Induced Filopodia Facilitate Human Respiratory Syncytial Virus Spread.
Mehedi M, McCarty T, Martin SE, Le Nouën C, Buehler E, Chen YC, Smelkinson M, Ganesan S, Fischer ER, Brock LG, Liang B, Munir S, Collins PL, Buchholz UJ., Free PMC Article | 06/3/2017 |
| Arp2 and Arp3 expression was increased under atherosclerotic conditions both in ApoE-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs). | ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression.
Tang Y, Zhao J, Shen L, Jin Y, Zhang Z, Xu G, Huang X. | 05/27/2017 |
| These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 in U251 human glioma cells. | Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.
Zhou T, Wang CH, Yan H, Zhang R, Zhao JB, Qian CF, Xiao H, Liu HY. | 02/18/2017 |
| Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13. | Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK., Free PMC Article | 09/3/2016 |
| demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties | Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
Abella JV, Galloni C, Pernier J, Barry DJ, Kjær S, Carlier MF, Way M. | 05/14/2016 |
| Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex. | Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG., Free PMC Article | 04/9/2016 |
| Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo. | α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.
Paul NR, Allen JL, Chapman A, Morlan-Mairal M, Zindy E, Jacquemet G, Fernandez del Ama L, Ferizovic N, Green DM, Howe JD, Ehler E, Hurlstone A, Caswell PT., Free PMC Article | 12/26/2015 |
| The loss of the Arp2/3 complex acts as a stress that initiates cell cycle arrest by triggering p16INK4a/p14Arf transcription. | Divide and conquer: the surprising link between motility and the cell cycle (retrospective on DOI 10.1002/bies.201200119).
Margolis RL. | 08/29/2015 |
| Coronin3 can regulate gastric cancer (GC) invasion and metastasis through Arp2, and the combination of Coronin3 and Arp2 provides a potential marker for predicting GC prognosis. | Coronin3 regulates gastric cancer invasion and metastasis by interacting with Arp2.
Sun Y, Shang Y, Ren G, Zhou L, Feng B, Li K, Deng L, Liang J, Lu Y, Wang X., Free PMC Article | 07/25/2015 |
| study unveils an ARP2/3:VCA-independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic role in actin polymerization. | Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.
Sadhukhan S, Sarkar K, Taylor M, Candotti F, Vyas YM., Free PMC Article | 08/23/2014 |
| Cortactin has a role as a scaffold for Arp2/3 and WAVE2 at the epithelial zonula adherens | Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.
Han SP, Gambin Y, Gomez GA, Verma S, Giles N, Michael M, Wu SK, Guo Z, Johnston W, Sierecki E, Parton RG, Alexandrov K, Yap AS., Free PMC Article | 05/17/2014 |
| The Arp2/Arp3 complex has a role in osmotic signaling. | Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling.
Wu C, Haynes EM, Asokan SB, Simon JM, Sharpless NE, Baldwin AS, Davis IJ, Johnson GL, Bear JE., Free PMC Article | 04/12/2014 |