| The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression. | The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression.
Capuano A, Vescovo M, Canesi S, Pivetta E, Doliana R, Nadin MG, Yamamoto M, Tsukamoto T, Nomura S, Pilozzi E, Palumbo A, Canzonieri V, Cannizzaro R, Scanziani E, Baldassarre G, Mongiat M, Spessotto P., Free PMC Article | 10/1/2024 |
| EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis. | EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.
Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Muiño-Mosquera L, Gulec EY, Gezdirici A, Braghetta P, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Schwarze U, Holmes KW, Hayflick SJ, Wiszniewski W, Nampoothiri S, Davis EC, Sakai LY, Sengle G, Callewaert B., Free PMC Article | 12/10/2022 |
| Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis. | Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis.
Amor López A, Mazariegos MS, Capuano A, Ximénez-Embún P, Hergueta-Redondo M, Recio JÁ, Muñoz E, Al-Shahrour F, Muñoz J, Megías D, Doliana R, Spessotto P, Peinado H., Free PMC Article | 08/14/2021 |
| Study demonstrated that EMILIN-1, by virtue of its interaction with beta1 integrins, is centrally located in the contest of colitis-associated cancer (CAC) by controlling the process of proliferation, tumor development and counteracting lymphatic dysfunction associated with chronic colonic inflammation. | Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis.
Capuano A, Pivetta E, Sartori G, Bosisio G, Favero A, Cover E, Andreuzzi E, Colombatti A, Cannizzaro R, Scanziani E, Minoli L, Bucciotti F, Amor Lopez AI, Gaspardo K, Doliana R, Mongiat M, Spessotto P. | 05/16/2020 |
| Increased blood pressure in mice with selective smooth muscle cell ablation of EMILIN-1 depends on transactivation of EGFR and enhanced myogenic tone. | Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans.
Carnevale D, Facchinello N, Iodice D, Bizzotto D, Perrotta M, De Stefani D, Pallante F, Carnevale L, Ricciardi F, Cifelli G, Da Ros F, Casaburo M, Fardella S, Bonaldo P, Innocenzi G, Rizzuto R, Braghetta P, Lembo G, Bressan GM. | 08/10/2019 |
| EMILIN-1 plays a role in the formation and maintenance of the elastic fiber system in the aorta but is not absolutely mandatory for the overall function of fibulin-4 or fibulin-5 in this microenvironment. | Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.
Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G., Free PMC Article | 01/26/2019 |
| Data suggested mechanisms for homo- and hetero-typic EMILINs multimers formation: EMILIN1 or EMILIN2 alone can form trimers and multimers in the absence of each other or they can co-polymerize in a head-to-tail fashion to form hetero-typic multimers. | Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains.
Bot S, Andreuzzi E, Capuano A, Schiavinato A, Colombatti A, Doliana R. | 10/10/2015 |
| Emilin1 deficiency results in aortic valve disease, mediated by non-canonical (MAPK/phosphorylated Erk1 and Erk2) TGF-beta dysregulation. | TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease.
Munjal C, Opoka AM, Osinska H, James JF, Bressan GM, Hinton RB., Free PMC Article | 04/4/2015 |
| EMILIN1/integrin alpha 9 beta 1 interaction contributes to lymphatic valve formation, maintenance, and function. | EMILIN1/α9β1 integrin interaction is crucial in lymphatic valve formation and maintenance.
Danussi C, Del Bel Belluz L, Pivetta E, Modica TM, Muro A, Wassermann B, Doliana R, Sabatelli P, Colombatti A, Spessotto P., Free PMC Article | 12/28/2013 |
| these data established that EMILIN1 exerts a protective role in tumor growth, in tumor lymphatic vessel formation, as well as in metastatic spread to lymph nodes | An EMILIN1-negative microenvironment promotes tumor cell proliferation and lymph node invasion.
Danussi C, Petrucco A, Wassermann B, Modica TM, Pivetta E, Del Bel Belluz L, Colombatti A, Spessotto P. | 04/13/2013 |
| Emilin-1 produced by vascular smooth muscle cells acts as a main regulator of resting blood pressure levels by controlling the myogenic response in resistance arteries through TGF-beta. | Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.
Litteri G, Carnevale D, D'Urso A, Cifelli G, Braghetta P, Damato A, Bizzotto D, Landolfi A, Ros FD, Sabatelli P, Facchinello N, Maffei A, Volpin D, Colombatti A, Bressan GM, Lembo G. | 11/3/2012 |
| Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 intracellular sequence that follows a predicted transmembrane domain in the C-terminus | CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1.
Selvakumar D, Drescher MJ, Dowdall JR, Khan KM, Hatfield JS, Ramakrishnan NA, Drescher DG., Free PMC Article | 05/19/2012 |
| EMILIN1 is identified as a novel ligand for keratinocyte alpha9beta1 integrin, suggesting prospective roles for this receptor-ligand pair in skin homeostasis. | EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
Danussi C, Petrucco A, Wassermann B, Pivetta E, Modica TM, Del Bel Belluz L, Colombatti A, Spessotto P., Free PMC Article | 11/19/2011 |
| EMILIN1 is a novel local regulator of lymphangiogenesis | Emilin1 deficiency causes structural and functional defects of lymphatic vasculature.
Danussi C, Spessotto P, Petrucco A, Wassermann B, Sabatelli P, Montesi M, Doliana R, Bressan GM, Colombatti A., Free PMC Article | 01/21/2010 |
| may regulate elastogenesis and vascular cell maintenance by stabilizing molecular interactions between elastic fiber components and by endowing elastic fibers with specific cell adhesion properties | EMILIN-1 deficiency induces elastogenesis and vascular cell defects.
Zanetti M, Braghetta P, Sabatelli P, Mura I, Doliana R, Colombatti A, Volpin D, Bonaldo P, Bressan GM., Free PMC Article | 01/21/2010 |
| transcription in different tissues is achieved through combinatorial cooperation between various regions | Analysis of regulatory regions of Emilin1 gene and their combinatorial contribution to tissue-specific transcription.
Fabbro C, de Gemmis P, Braghetta P, Colombatti A, Volpin D, Bonaldo P, Bressan GM. | 01/21/2010 |