| The ceramide transport protein CERT is involved in alkylacylglycerol transfer from the ER to the Golgi for the biosynthesis of ether phospholipid. | The ceramide transport protein CERT is involved in alkylacylglycerol transfer from the ER to the Golgi for the biosynthesis of ether phospholipid.
Horibata Y, Sugimoto H. | 02/1/2024 |
| CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. | CERT1 mutations perturb human development by disrupting sphingolipid homeostasis.
Gehin C, Lone MA, Lee W, Capolupo L, Ho S, Adeyemi AM, Gerkes EH, Stegmann AP, López-Martín E, Bermejo-Sánchez E, Martínez-Delgado B, Zweier C, Kraus C, Popp B, Strehlow V, Gräfe D, Knerr I, Jones ER, Zamuner S, Abriata LA, Kunnathully V, Moeller BE, Vocat A, Rommelaere S, Bocquete JP, Ruchti E, Limoni G, Van Campenhoudt M, Bourgeat S, Henklein P, Gilissen C, van Bon BW, Pfundt R, Willemsen MH, Schieving JH, Leonardi E, Soli F, Murgia A, Guo H, Zhang Q, Xia K, Fagerberg CR, Beier CP, Larsen MJ, Valenzuela I, Fernández-Álvarez P, Xiong S, Śmigiel R, López-González V, Armengol L, Morleo M, Selicorni A, Torella A, Blyth M, Cooper NS, Wilson V, Oegema R, Herenger Y, Garde A, Bruel AL, Tran Mau-Them F, Maddocks AB, Bain JM, Bhat MA, Costain G, Kannu P, Marwaha A, Champaigne NL, Friez MJ, Richardson EB, Gowda VK, Srinivasan VM, Gupta Y, Lim TY, Sanna-Cherchi S, Lemaitre B, Yamaji T, Hanada K, Burke JE, Jakšić AM, McCabe BD, De Los Rios P, Hornemann T, D'Angelo G, Gennarino VA., Free PMC Article | 05/17/2023 |
| Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer. | Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer.
Chung LH, Liu D, Liu XT, Qi Y., Free PMC Article | 02/5/2022 |
| Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution. | Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution.
Tamura N, Sakai S, Martorell L, Colomé R, Mizuike A, Goto A, Ortigoza-Escobar JD, Hanada K., Free PMC Article | 12/18/2021 |
| A switchable ceramide transfer protein for dissecting the mechanism of ceramide-induced mitochondrial apoptosis. | A switchable ceramide transfer protein for dissecting the mechanism of ceramide-induced mitochondrial apoptosis.
Jain A, Dadsena S, Holthuis JCM. | 05/29/2021 |
| Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics. | Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics.
Giovagnoni C, Crivelli SM, Losen M, Martinez-Martinez P. | 03/20/2021 |
| Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT. | Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT.
Murakami H, Tamura N, Enomoto Y, Shimasaki K, Kurosawa K, Hanada K., Free PMC Article | 02/20/2021 |
| findings reveal the presence of GPBP in unicellular protists, with GPBP-2 as the most ancient isoform. In vertebrates, GPBP-1 assumed extracellular function that is further enhanced by membrane-bound GPBP-3 in mammalians, whereas GPBP-2 retained intracellular function. | Unicellular ancestry and mechanisms of diversification of Goodpasture antigen-binding protein.
Darris C, Revert F, Revert-Ros F, Gozalbo-Rovira R, Feigley A, Fidler A, Lopez-Pascual E, Saus J, Hudson BG., Free PMC Article | 04/20/2019 |
| the size and number of multivesicular bodies were comparable in WT and STARD11-knockout cells. In conclusion, we propose a model of how STARD11 mediates ceramide trafficking in palmitate-treated cells and stimulates exosome biogenesis. | StAR-related lipid transfer domain 11 (STARD11)-mediated ceramide transport mediates extracellular vesicle biogenesis.
Fukushima M, Dasgupta D, Mauer AS, Kakazu E, Nakao K, Malhi H., Free PMC Article | 03/9/2019 |
| Importance of Endoplasmic reticulum to Golgi ceramide traffic to preserve muscle cell insulin signaling, CERT as a major actor in this process. | Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions.
Bandet CL, Mahfouz R, Véret J, Sotiropoulos A, Poirier M, Giussani P, Campana M, Philippe E, Blachnio-Zabielska A, Ballaire R, Le Liepvre X, Bourron O, Berkeš D, Górski J, Ferré P, Le Stunff H, Foufelle F, Hajduch E. | 08/18/2018 |
| Data suggest that isolated PH and START domains of CERT interact with each other; START domain binds to PH domain at same site for PtdIns[4]P-binding; mutations disrupting PH-START interaction increase both PtdIns[4]P-binding affinity and ceramide transfer activity. (PH domain = N-terminal pleckstrin homology domain; START domain = StAR-related lipid transfer domain; PtdIns[4]P = phosphatidylinositol 4-phosphate) | Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain.
Prashek J, Bouyain S, Fu M, Li Y, Berkes D, Yao X., Free PMC Article | 09/16/2017 |
| Cells expressing mitoCERT import ceramides into mitochondria and undergo Bax-dependent apoptosis. | Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis.
Jain A, Beutel O, Ebell K, Korneev S, Holthuis JC. | 08/12/2017 |
| phosphorylation of CERT at the FFAT motif-adjacent serine affects its affinity for VAP, which may regulate the inter-organelle trafficking of ceramide in response to the perturbation of cellular sphingomyelin and/or other sphingolipids | Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.
Kumagai K, Kawano-Kawada M, Hanada K., Free PMC Article | 06/21/2014 |
| Both CERT isoforms, when immobilized, bind the globular head region of C1q and initiate the classical complement pathway. C1q binds endogenous CERTL on the surface of apoptotic cells. | Complement activation by ceramide transporter proteins.
Bode GH, Losen M, Buurman WA, Veerhuis R, Molenaar PC, Steinbusch HW, De Baets MH, Daha MR, Martinez-Martinez P. | 03/29/2014 |
| Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT) | Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT).
Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I., Free PMC Article | 12/22/2012 |
| CERT is at a convergence point of non-vesicular and vesicular transport processes and plays a central role within the PKD signaling network at the Golgi complex. (Review) | Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
Olayioye MA, Hausser A. | 11/3/2012 |
| Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. | Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer.
Heering J, Weis N, Holeiter M, Neugart F, Staebler A, Fehm TN, Bischoff A, Schiller J, Duss S, Schmid S, Korte T, Herrmann A, Olayioye MA. | 08/11/2012 |
| The START domain in GPBP is important for this interaction. SAP and GPBP form complexes in blood and partly colocalize in amyloid plaques from Alzheimer disease patients. | Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.
Mencarelli C, Bode GH, Losen M, Kulharia M, Molenaar PC, Veerhuis R, Steinbusch HW, De Baets MH, Nicolaes GA, Martinez-Martinez P., Free PMC Article | 07/7/2012 |
| This review is focused on ceramide transfer protein (CERT) as a major regulator of ceramide flux in the cell. [review] | Ceramide transfer protein and cancer.
Scheffer L, Raghavendra PR, Ma J, Acharya JK., Free PMC Article | 05/5/2012 |
| during cellular stress, disassembly of Golgi structure together with inactivation of CERT by caspases causes a reduction in ceramide trafficking and sphingomyelin synthesis, and could contribute to the cellular response to pro-apoptotic stress | Inactivation of ceramide transfer protein during pro-apoptotic stress by Golgi disassembly and caspase cleavage.
Chandran S, Machamer CE., Free PMC Article | 04/14/2012 |
| the presence of IncD, CERT, VAPA/B, and potentially additional host and/or bacterial factors, at points of contact between the ER and the inclusion membrane provides a specialized microenvironment favorable to bacterial development. | The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites.
Derré I, Swiss R, Agaisse H., Free PMC Article | 01/14/2012 |
| We hypothesize that sphingomyelin acquired by CERT-dependent transport of ceramide and subsequent conversion to SM is necessary for C. trachomatis replication whereas SM acquired by GBF1-dependent pathway is essential for inclusion growth and stability. | Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.
Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, Engel JN., Free PMC Article | 01/7/2012 |
| GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein | Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).
Revert-Ros F, López-Pascual E, Granero-Moltó F, Macías J, Breyer R, Zent R, Hudson BG, Saadeddin A, Revert F, Blasco R, Navarro C, Burks D, Saus J., Free PMC Article | 12/10/2011 |
| PKD negatively regulates HCV secretion/release by attenuating OSBP and CERT functions by phosphorylation inhibition. This study identifies the key role of the Golgi components in the HCV maturation process. | Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein.
Amako Y, Syed GH, Siddiqui A., Free PMC Article | 06/4/2011 |
| the membrane matrix surrounding ceramide, that is ceramide miscibility, is largely affecting the transfer activity of CERT | The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment.
Tuuf J, Kjellberg MA, Molotkovsky JG, Hanada K, Mattjus P. | 03/12/2011 |