| The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation. | The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.
Lee C, Park SH, Yoon SK. | 02/26/2024 |
| The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis. | The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
Li XX, Xu JK, Su WJ, Wu HL, Zhao K, Zhang CM, Chen XK, Yang LX. | 02/9/2024 |
| A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARalpha pathway in Chinese individuals. | A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals.
Shan X, Zhang X, Huang G, Lv J, Ye Z, Jiang C, Jiang X, Cheng J, Lin H, Jiang H, Yue H, Wang Z, Xu W. | 01/16/2024 |
| A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-11q splice variant. | A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.
Pettitt SJ, Shao N, Zatreanu D, Frankum J, Bajrami I, Brough R, Krastev DB, Roumeliotis TI, Choudhary JS, Lorenz S, Rust A, de Bono JS, Yap TA, Tutt ANJ, Lord CJ., Free PMC Article | 09/8/2023 |
| HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation. | HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Scinicariello S, Soderholm A, Schäfer M, Shulkina A, Schwartz I, Hacker K, Gogova R, Kalis R, Froussios K, Budroni V, Bestehorn A, Clausen T, Kovarik P, Zuber J, Versteeg GA., Free PMC Article | 03/28/2023 |
| The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression. | The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression.
Yuan Y, Wang LH, Zhao XX, Wang J, Zhang MS, Ma QH, Wei S, Yan ZX, Cheng Y, Chen XQ, Zou HB, Ge J, Wang Y, Zhang X, Cui YH, Luo T, Bian XW., Free PMC Article | 09/24/2022 |
| TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1. | TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
Li D, Zhang Z. | 09/10/2022 |
| The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases. | The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases.
Qi L, Xu X, Qi X., Free PMC Article | 08/13/2022 |
| E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of beta-PDGFR. | E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.
Pham T, Najy AJ, Kim HC., Free PMC Article | 07/2/2022 |
| Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation. | Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.
Zhou Y, Zheng R, Liu S, Disoma C, Du A, Li S, Chen Z, Dong Z, Zhang Y, Li S, Liu P, Razzaq A, Chen X, Liao Y, Tao S, Liu Y, Xu L, Zhang Q, Peng J, Deng X, Li S, Jiang T, Xia Z., Free PMC Article | 03/5/2022 |
| Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities. | Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities.
Aprigliano R, Aksu ME, Bradamante S, Mihaljevic B, Wang W, Rian K, Montaldo NP, Grooms KM, Fordyce Martin SL, Bordin DL, Bosshard M, Peng Y, Alexov E, Skinner C, Liabakk NB, Sullivan GJ, Bjørås M, Schwartz CE, van Loon B., Free PMC Article | 03/5/2022 |
| The E3 ligase HUWE1 mediates TGFBR2 ubiquitination and promotes gastric cancer cell proliferation, migration, and invasion. | The E3 ligase HUWE1 mediates TGFBR2 ubiquitination and promotes gastric cancer cell proliferation, migration, and invasion.
He Y, Zhou J, Wan Q. | 02/19/2022 |
| Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Hunkeler M, Jin CY, Ma MW, Monda JK, Overwijn D, Bennett EJ, Fischer ES., Free PMC Article | 10/23/2021 |
| ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells. | ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
Lee J, Kim J, Shin J, Kang Y, Choi J, Cheong H., Free PMC Article | 10/16/2021 |
| Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients. | Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients.
Andey T, Attah MM, Akwaaba-Reynolds NA, Cheema S, Parvin-Nejad S, Acquaah-Mensah GK. | 09/25/2021 |
| Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease. | Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease.
Giles AC, Grill B., Free PMC Article | 08/28/2021 |
| HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate. | HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate.
Ruckert MT, Brouwers-Vos AZ, Nagano LFP, Schuringa JJ, Silveira VS. | 08/21/2021 |
| HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy. | HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.
Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, Melino G, Cecconi F., Free PMC Article | 07/3/2021 |
| Analysis of exome-sequenced UK Biobank subjects implicates genes affecting risk of hyperlipidaemia. | Analysis of exome-sequenced UK Biobank subjects implicates genes affecting risk of hyperlipidaemia.
Curtis D. | 07/3/2021 |
| Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1. | Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.
Cassidy KB, Bang S, Kurokawa M, Gerber SA., Free PMC Article | 04/24/2021 |
| Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis. | Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis.
Li L, Kong XA, Zang M, Dong J, Feng Y, Gui B, Hu Y., Free PMC Article | 03/27/2021 |
| Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models. | Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
Kunz V, Bommert KS, Kruk J, Schwinning D, Chatterjee M, Stühmer T, Bargou R, Bommert K., Free PMC Article | 03/13/2021 |
| HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response. | HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.
Guo Z, Wang S, Xie Y, Han Y, Hu S, Guan H, Xie D, Bai C, Liu X, Gu Y, Zhou PK, Ma T., Free PMC Article | 03/13/2021 |
| HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. | HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
Guo Y, Li L, Xu T, Guo X, Wang C, Li Y, Yang Y, Yang D, Sun B, Zhao X, Shao G, Qi X., Free PMC Article | 02/20/2021 |
| The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma. | The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.
Crawford LJ, Campbell DC, Morgan JJ, Lawson MA, Down JM, Chauhan D, McAvera RM, Morris TC, Hamilton C, Krishnan A, Rajalingam K, Chantry AD, Irvine AE., Free PMC Article | 11/28/2020 |