| Identification and biological analysis of LncSPRY4-IT1-targeted functional proteins in photoaging skin. | Identification and biological analysis of LncSPRY4-IT1-targeted functional proteins in photoaging skin.
Hou W, Lin Y, Xu W, Chen H, Liu Y, Li C, Zheng Y. | 01/29/2022 |
| NF-kappaB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay. | NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay.
Zhao L, Jiang L, Zhang M, Zhang Q, Guan Q, Li Y, He M, Zhang J, Wei M., Free PMC Article | 01/8/2022 |
| Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes. | Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes.
Abd-Elmawla MA, Hassan M, Elsabagh YA, Alnaggar ARLR, Senousy MA. | 10/9/2021 |
| LncRNA SPRY4-IT1 regulates breast cancer cell stemness through competitively binding miR-6882-3p with TCF7L2. | LncRNA SPRY4-IT1 regulates breast cancer cell stemness through competitively binding miR-6882-3p with TCF7L2.
Song X, Zhang X, Wang X, Chen L, Jiang L, Zheng A, Zhang M, Zhao L, Wei M., Free PMC Article | 05/15/2021 |
| Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database. | Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database.
Wang HM, Li HJ, Chen JZ, Pei K, Zhang Q, Liu ZD, Qi YF., Free PMC Article | 04/17/2021 |
| Clinical significance of SPRY4-IT1 in efficacy and survival prediction in breast cancer patients undergoing neoadjuvant chemotherapy. | Clinical significance of SPRY4-IT1 in efficacy and survival prediction in breast cancer patients undergoing neoadjuvant chemotherapy.
Zheng A, Zhang L, Song X, Jin F. | 04/3/2021 |
| Long noncoding RNA SPRY4-IT1 promotes proliferation and metastasis of hepatocellular carcinoma via mediating TNF signaling pathway. | Long noncoding RNA SPRY4-IT1 promotes proliferation and metastasis of hepatocellular carcinoma via mediating TNF signaling pathway.
Ma W, Chen X, Wu X, Li J, Mei C, Jing W, Teng L, Tu H, Jiang X, Wang G, Chen Y, Wang K, Wang H, Wei Y, Liu Z, Yuan Y. | 03/13/2021 |
| Expression profiling revealed up-regulation of three lncRNAs in breast cancer samples. | Expression profiling revealed up-regulation of three lncRNAs in breast cancer samples.
Mohebi M, Sattari A, Ghafouri-Fard S, Modarressi MH, Kholghi-Oskooei V, Taheri M. | 02/6/2021 |
| LncRNA SPRY4IT1 promotes progression of osteosarcoma by regulating ZEB1 and ZEB2 expression through sponging of miR101 activity. | LncRNA SPRY4‑IT1 promotes progression of osteosarcoma by regulating ZEB1 and ZEB2 expression through sponging of miR‑101 activity.
Yao H, Hou G, Wang QY, Xu WB, Zhao HQ, Xu YC., Free PMC Article | 10/24/2020 |
| Findings indicate that the SPYR4-IT1/miR-101-3p/zinc finger E-box binding homeobox 1 protein (ZEB1) axis contributes to cervical cancer (CC) migration and invasion, which may provide novel insights into the function of lncRNA-driven tumorigenesis of CC. | Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis.
Fan MJ, Zou YH, He PJ, Zhang S, Sun XM, Li CZ., Free PMC Article | 08/12/2020 |
| High SPRY4-IT1 expression is associated with development of hepatic cellular carcinoma. | Long non-coding RNA SPRY4-IT1 promotes development of hepatic cellular carcinoma by interacting with ERRα and predicts poor prognosis.
Yu G, Lin J, Liu C, Hou K, Liang M, Shi B., Free PMC Article | 07/27/2019 |
| We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast cancer cells and whether N-terminal polypeptide derived from viral macrophage inflammatory protein II (NT21MP) could exert its anti-tumor effect by regulating lncRNA SPRY4-IT1 and its target gene SKA2 | The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1.
Wu H, Wang Y, Chen T, Li Y, Wang H, Zhang L, Chen S, Wang W, Yang Q, Chen C., Free PMC Article | 05/18/2019 |
| SPRY4-IT1 is upregulated in human CCA tissues and cells, and its overexpression may be an unfavorable prognostic factor for patients with CCA. | SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma.
Xu Y, Yao Y, Jiang X, Zhong X, Wang Z, Li C, Kang P, Leng K, Ji D, Li Z, Huang L, Qin W, Cui Y., Free PMC Article | 05/11/2019 |
| Increased expression level of SPRY4-IT1 correlated with lymph node metastasis in Digestive System Malignancies. | Long Non-Coding RNA SPRY4-IT1 Can Predict Poor Prognosis in Digestive System Malignancies: a Meta-Analysis.
Sun C, Ding Y, Wang S, Hu W. | 02/16/2019 |
| Mechanism assays noted that silenced SPRY4-IT1 could increase the levels of transforming growth factor-beta1 (TGF-beta1) and p-Smad2/3 and function mediated by si-SPRY4-IT1 could be rescued by the interference of TGF-beta1. | LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer.
Zhou H, Sun Z, Li S, Wang X, Zhou X. | 01/12/2019 |
| The findings indicate that SPRY4 and SPRY4-IT1 may act as oncogenes in testicular germ cell tumors via activation of the PI3K/Akt signaling pathway. | Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours.
Das MK, Furu K, Evensen HF, Haugen ØP, Haugen TB., Free PMC Article | 12/22/2018 |
| Significantly decreases SPRIGHTLY lncRNA levels. | The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules.
Lee B, Sahoo A, Marchica J, Holzhauser E, Chen X, Li JL, Seki T, Govindarajan SS, Markey FB, Batish M, Lokhande SJ, Zhang S, Ray A, Perera RJ., Free PMC Article | 10/13/2018 |
| LncRNA SPRY4-IT1 can serve as a new molecular marker for cancer metastasis and prognosis | Long Non-Coding RNA SPRY4-IT1 Can Predict Unfavorable Prognosis and Lymph Node Metastasis: a Meta-Analysis.
Li N, Tan Q, Jing W, Luo P, Tu J. | 07/28/2018 |
| Long non-coding RNA SPRY4-IT1 promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells | Long non-coding RNA SPRY4-IT1 promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells.
Guo W, Zhong K, Wei H, Nie C, Yuan Z., Free PMC Article | 06/2/2018 |
| results highlight the roles of SPRY4-IT1 in causing trophoblast cell dysfunction by acting through the Wnt/beta-catenin pathway, and consequently in impairing spiral artery remodelling. | The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal Transition.
Zuo Q, Huang S, Zou Y, Xu Y, Jiang Z, Zou S, Xu H, Sun L., Free PMC Article | 05/19/2018 |
| Results demonstrated that SPRY4-IT1 was abnormally upregulated in pancreatic ductal adenocarcinoma (PDAC ) tissues and cell lines. Tumor stage and differentiation grade was closely correlated with SPRY4-IT1 expression. Additionally, decreased SPRY4-IT1 contributed to tumor suppressive effect through attenuating cell growth, clonogenic ability and facilitating apoptosis via Bcl-2/caspase-3 pathway in PDAC. | Upregulated long non-coding RNA SPRY4-IT1 predicts dismal prognosis for pancreatic ductal adenocarcinoma and regulates cell proliferation and apoptosis.
Yao Y, Gao P, Chen L, Wang W, Zhang J, Li Q, Xu Y. | 05/12/2018 |
| the meta-analysis results suggested that increased expression level of SPRY4-IT1 was positively associated with unfavorable prognosis and advanced features of cancers in cancer patients but not in patients with NSCLC. | Prognostic role of the long non-coding RNA, SPRY4 Intronic Transcript 1, in patients with cancer: a meta-analysis.
Wang M, Dong X, Feng Y, Sun H, Shan N, Lu T., Free PMC Article | 03/10/2018 |
| these researches indicated that SPRY4-IT1 is highly expressed in GBC. SPRY4-IT1 promotes the growth and migration of GBC cells, suggesting that SPRY4-IT1 may be an important contributor to GBC development. | Long non-coding RNA SPRY4-IT1 promotes gallbladder carcinoma progression.
Yang L, Cheng X, Ge N, Guo W, Feng F, Wan F., Free PMC Article | 03/10/2018 |
| meta-analysis of value as prognostic biomarker of survival in cancer | TUG1, SPRY4-IT1, and HULC as valuable prognostic biomarkers of survival in cancer: A PRISMA-compliant meta-analysis.
Zhong Y, Chen Z, Guo S, Liao X, Xie H, Zheng Y, Cai B, Huang P, Liu Y, Zhou Q, Liu Y, Huang W., Free PMC Article | 12/2/2017 |
| High SPRY4-IT1 expression is associated with colorectal cancer metastasis. | Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition.
Shen F, Cai WS, Feng Z, Chen JW, Feng JH, Liu QC, Fang YP, Li KP, Xiao HQ, Cao J, Xu B., Free PMC Article | 10/14/2017 |