| The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells. | The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells.
López-Haber C, Netting DJ, Hutchins Z, Ma X, Hamilton KE, Mantegazza AR., Free PMC Article | 10/22/2022 |
| The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes. | The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes.
Rimann I, Gonzalez-Quintial R, Baccala R, Kiosses WB, Teijaro JR, Parker CG, Li X, Beutler B, Kono DH, Theofilopoulos AN., Free PMC Article | 05/7/2022 |
| The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models. | The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models.
Katewa A, Suto E, Hui J, Heredia J, Liang J, Hackney J, Anderson K, Alcantar TM, Bacarro N, Dunlap D, Eastham J, Paler-Martinez A, Rairdan XY, Modrusan Z, Lee WP, Austin CD, Lafkas D, Ghilardi N., Free PMC Article | 04/24/2021 |
| A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. | A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice.
Griffith AD, Zaidi AK, Pietro A, Hadiono M, Yang JS, Davis R, Popkin DL., Free PMC Article | 10/26/2019 |
| this study shows that SLC15A4 mediates the transport of bacterially derived di/tripeptides to enhance the nucleotide-binding oligomerization domain-dependent immune response in mouse bone marrow-derived macrophages | SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages.
Hu Y, Song F, Jiang H, Nuñez G, Smith DE., Free PMC Article | 07/6/2019 |
| this study demonstrated that SLC15A4 is required for mast-cell secretory-granule homeostasis, and limits mast-cell functions and inflammatory responses by controlling the mTORC1-TFEB signaling axis | Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
Kobayashi T, Tsutsui H, Shimabukuro-Demoto S, Yoshida-Sugitani R, Karyu H, Furuyama-Tanaka K, Ohshima D, Kato N, Okamura T, Toyama-Sorimachi N., Free PMC Article | 02/2/2019 |
| Slc15a4 is required for intact function of TLR9-expressing cells and for effective antibody isotype switching to IgG2c. | Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.
Dosenovic P, Ádori M, Adams WC, Pedersen GK, Soldemo M, Beutler B, Karlsson Hedestam GB. | 12/19/2015 |
| SLC15A4-mediated optimization of the endolysosomal state is integral to a Toll-like receptor 7-triggered, mTOR-dependent interferon regulatory factor 7-type I interferon circuit that leads to autoantibody production. | The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N. | 11/22/2014 |
| We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate | Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
Hu Y, Xie Y, Keep RF, Smith DE., Free PMC Article | 08/30/2014 |
| the feeble mutation (Slc15a4) affecting Plasmacytoid dendritic cells is dispensable for immunity during an acute infection; however, data show that feeble mice failed to control a chronic infection | Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection.
Blasius AL, Krebs P, Sullivan BM, Oldstone MB, Popkin DL., Free PMC Article | 05/11/2013 |
| results demonstrate pDCs and the production of type I IFNs by these cells are critical contributors to the pathogenesis of lupus-like autoimmunity in these models. IRF8 and SLC15A4 may provide important targets for therapeutic intervention in human lupus | Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
Baccala R, Gonzalez-Quintial R, Blasius AL, Rimann I, Ozato K, Kono DH, Beutler B, Theofilopoulos AN., Free PMC Article | 04/27/2013 |
| SLC15A4 promotes colitis through Toll-like receptor 9 and NOD1-dependent innate immune responses. | The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice.
Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N. | 07/2/2011 |
| The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2 are essential for plasmacytoid dendritic cells signaling through TLR7 and TLR9. | Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.
Blasius AL, Arnold CN, Georgel P, Rutschmann S, Xia Y, Lin P, Ross C, Li X, Smart NG, Beutler B., Free PMC Article | 01/1/2011 |