| UBA2 as a Prognostic Biomarker and Potential Therapeutic Target in Glioma. | UBA2 as a Prognostic Biomarker and Potential Therapeutic Target in Glioma.
Ou Y, Luo H, Zhang Q, Du T, Liu R, Wang D, Chen J, Dong M, Wang Y, Yang Z, Wang X. | 06/3/2024 |
| UBA2 promotes the progression of renal cell carcinoma by suppressing the p53 signaling. | UBA2 promotes the progression of renal cell carcinoma by suppressing the p53 signaling.
Du X, Shi J. | 07/30/2022 |
| Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. | Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics.
Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Magolan J, Collins TJ, Wright GD, Bhatia M., Free PMC Article | 01/8/2022 |
| UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly. | UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly.
Schnur RE, Yousaf S, Liu J, Chung WK, Rhodes L, Marble M, Zambrano RM, Sobreira N, Jayakar P, Pierpont ME, Schultz MJ, Pichurin PN, Olson RJ, Graham GE, Osmond M, Contreras-García GA, Campo-Neira KA, Peñaloza-Mantilla CA, Flage M, Kuppa S, Navarro K, Sacoto MJG, Wentzensen IM, Scarano MI, Juusola J, Prada CE, Hufnagel RB., Free PMC Article | 10/23/2021 |
| Genome sequencing in families with congenital limb malformations. | Genome sequencing in families with congenital limb malformations.
Elsner J, Mensah MA, Holtgrewe M, Hertzberg J, Bigoni S, Busche A, Coutelier M, de Silva DC, Elçioglu N, Filges I, Gerkes E, Girisha KM, Graul-Neumann L, Jamsheer A, Krawitz P, Kurth I, Markus S, Megarbane A, Reis A, Reuter MS, Svoboda D, Teller C, Tuysuz B, Türkmen S, Wilson M, Woitschach R, Vater I, Caliebe A, Hülsemann W, Horn D, Mundlos S, Spielmann M., Free PMC Article | 07/17/2021 |
| UBA2 activates Wnt/beta-catenin signaling pathway during protection of R28 retinal precursor cells from hypoxia by extracellular vesicles derived from placental mesenchymal stem cells. | UBA2 activates Wnt/β-catenin signaling pathway during protection of R28 retinal precursor cells from hypoxia by extracellular vesicles derived from placental mesenchymal stem cells.
Koh K, Park M, Bae ES, Duong VA, Park JM, Lee H, Lew H., Free PMC Article | 07/3/2021 |
| Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes. | Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes.
Wang C, Xiao Y, Lao M, Wang J, Xu S, Li R, Xu X, Kuang Y, Shi M, Zou Y, Wang Q, Liang L, Zheng SG, Xu H., Free PMC Article | 06/5/2021 |
| Identifying UBA2 as a proliferation and cell cycle regulator in lung cancer A549 cells. | Identifying UBA2 as a proliferation and cell cycle regulator in lung cancer A549 cells.
Jiang B, Fan X, Zhang D, Liu H, Fan C. | 08/15/2020 |
| the results together with previous data such as the development of Split-hand/foot malformation (SHFM) in Lrp6 knockout mice, the presence of SHFM in two subjects with 19q13 deletions involving UBA2, and strong mouse Uba2 expression in the developing limb buds, imply that LRP6 and UBA2 represent plausible candidate genes for SHFM. | Comprehensive clinical and molecular studies in split-hand/foot malformation: identification of two plausible candidate genes (LRP6 and UBA2).
Yamoto K, Saitsu H, Nishimura G, Kosaki R, Takayama S, Haga N, Tonoki H, Okumura A, Horii E, Okamoto N, Suzumura H, Ikegawa S, Kato F, Fujisawa Y, Nagata E, Takada S, Fukami M, Ogata T., Free PMC Article | 07/18/2020 |
| The findings suggest that the UBA2-WTIP fusion is an oncogenic fusion gene, as well as a promising therapeutic target for the treatment of acute myeloid leukemia. | Identification of the UBA2-WTIP fusion gene in acute myeloid leukemia.
Lu X, Zhuang H, Yu Q, Zhang X, Wu Z, Zhang L, Xu Y, Wu B, Yang L, Ma A, Gan X, Yu X, Shen J, Xu R. | 09/21/2019 |
| the results suggest that Uba2 participates in the progression, invasion, and metastasis of colorectal cancer, and the possible mechanism is via regulating the Wnt signaling pathway and enhancing epithelial-mesenchymal transition behaviors of colorectal cancer cells. | Knockdown of Uba2 inhibits colorectal cancer cell invasion and migration through downregulation of the Wnt/β-catenin signaling pathway.
Cheng H, Sun X, Li J, He P, Liu W, Meng X. | 05/18/2019 |
| results from the present study indicated that UBA2 expression may enhance colorectal cancer cell proliferation and inhibit apoptosis. | UBA2 promotes proliferation of colorectal cancer.
He P, Sun X, Cheng HJ, Zou YB, Wang Q, Zhou CL, Liu WQ, Hao YM, Meng XW., Free PMC Article | 02/2/2019 |
| Uba2 plays a vital role in gastric cancer cell migration and invasion, possibly by regulating the Wnt/beta-catenin signaling pathway and epithelial-mesenchymal transition. | Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/β-catenin signaling in gastric cancer.
Li J, Sun X, He P, Liu WQ, Zou YB, Wang Q, Meng XW., Free PMC Article | 01/12/2019 |
| Calcium/calpain-induced cleavage of the SAE2 leads to sumoylation inhibition reslting in bacillary dysentery. | Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation.
Lapaquette P, Fritah S, Lhocine N, Andrieux A, Nigro G, Mounier J, Sansonetti P, Dejean A., Free PMC Article | 09/15/2018 |
| We propose that disturbance of the SUMOylation pathway, mediated by pathogenic variants in UBA2, is a novel mechanism for aplasia cutis congenita and other phenotypic abnormalities. | Missense variant in UBA2 associated with aplasia cutis congenita, duane anomaly, hip dysplasia and other anomalies: A possible new disorder involving the SUMOylation pathway.
Marble M, Guillen Sacoto MJ, Chikarmane R, Gargiulo D, Juusola J. | 10/21/2017 |
| Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus. | Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 (hHR23A) requires its xeroderma pigmentosum complementation group C binding (XPCB) domain as well as the ubiquitin-associated 2 (UBA2) domain.
Jung J, Byeon IJ, DeLucia M, Koharudin LM, Ahn J, Gronenborn AM., Free PMC Article | 04/12/2014 |
| This study has identified the mechanism used to localize SAE to the nucleus. | Sumoylation of SAE2 C terminus regulates SAE nuclear localization.
Truong K, Lee TD, Li B, Chen Y., Free PMC Article | 02/16/2013 |
| Data indicate the role of anti-SUMO activating enzyme SAE1 and SAE2 antibody as marker of dermatomyositis. | Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort.
Tarricone E, Ghirardello A, Rampudda M, Bassi N, Punzi L, Doria A. | 12/8/2012 |
| Data show that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2. | Small ubiquitin-like modifier (SUMO) modification of E1 Cys domain inhibits E1 Cys domain enzymatic activity.
Truong K, Lee TD, Chen Y., Free PMC Article | 08/4/2012 |
| loss of SAE1/2 activity drives synthetic lethality with Myc; inactivation of SAE2 leads to mitotic catastrophe and cell death upon Myc hyperactivation; findings in Myc-high breast cancers suggest low tumor SAE1 and SAE2 correlates metastasis-free survival | A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF., Free PMC Article | 02/4/2012 |
| The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells. | Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme.
Moutty MC, Sakin V, Melchior F., Free PMC Article | 06/18/2011 |
| UBA2 stabilizes APOBEC3G by preventing ubiquitin chain elongation and proteasome-mediated proteolysis. | APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication.
Li L, Liang D, Li JY, Zhao RY., Free PMC Article | 01/21/2010 |
| structures of heterodimeric Sae1/Sae2-Mg.ATP and Sae1/Sae2-SUMO-1-Mg.ATP complexes | Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.
Lois LM, Lima CD., Free PMC Article | 01/21/2010 |