| Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression. | Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression.
Wang J, Shao J, Lu Y, Su W, Dong H, Wang P, Lin Z, Feng J, Wang D, Zhao H, Tan J. | 07/26/2024 |
| Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/beta-catenin Signaling Pathway. | Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/β-catenin Signaling Pathway.
Zhu M, Zhang X, Gao K, Zhang L, Feng X, Wang H, Li J, Jia J. | 05/29/2024 |
| FoxO1 promotes ovarian cancer by increasing transcription and METTL14-mediated m[6]A modification of SMC4. | FoxO1 promotes ovarian cancer by increasing transcription and METTL14-mediated m(6)A modification of SMC4.
Tan L, Wang S, Huang S, Tie Y, Sai N, Mao Y, Zhao S, Hou Y, Dou H., Free PMC Article | 04/24/2024 |
| TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway. | TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Yang Z, Pan X, Wu X, Lin Q, Chen Y, Cai S, Zhang Y, Mai Z, Ahmad N, Ma D, Deng L. | 03/22/2023 |
| MiR-433-3p restrains the proliferation, migration and invasion of glioma cells via targeting SMC4. | MiR-433-3p restrains the proliferation, migration and invasion of glioma cells via targeting SMC4.
You A, Rao G, Wang J, Li J, Zhang Y, Gu J, Ge X, Zhang K, Gao X, Wu X, Cheng L, Zhu M, Wang D. | 03/26/2022 |
| SMC4 knockdown inhibits malignant biological behaviors of endometrial cancer cells by regulation of FoxO1 activity. | SMC4 knockdown inhibits malignant biological behaviors of endometrial cancer cells by regulation of FoxO1 activity.
Yan Y, Liu C, Zhang J, Li W, Yin X, Dong L, Pang S, Li X. | 12/4/2021 |
| Study found that mRNA expression of SMC4 was upregulated in invasive breast cancer cells. Patients with high mRNA level of SMC4 suffered different survival with triple negative breast cancer (TNBC) and non-TNBC. These results suggest that SMC4 could be a good biomarker for predicting the prognosis. | The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer.
Ma RM, Yang F, Huang DP, Zheng M, Wang YL., Free PMC Article | 05/9/2020 |
| study demonstrated a novel HIF-1-miR-219-SMC4 regulatory pathway under hypoxic condition in hepatocellular carcinoma cells. | HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition.
Chen Y, Huang F, Deng L, Yuan X, Tao Q, Wang T, Li D, Fan Y, Peng Q, Tang D., Free PMC Article | 04/25/2020 |
| this paper shows that condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription | Condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription.
Wang Q, Wang C, Li N, Liu X, Ren W, Wang Q, Cao X. | 06/29/2019 |
| Study examined the expression of SMC4 in acute myeloid leukemia (AML) pediatric patients cells and normal cells and revealed that SMC4 was significantly higher than control. Utilizing SMC4 gene knockdown in the established MLL-AF9 AML mouse model study found that SMC4 knockdown inhibited AML progression by maintaining leukemia stem cells. | Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.
Peng L, Tang Y, Zhang Y, Guo S, Peng L, Ye L, Wang Y, Jiang Y. | 06/8/2019 |
| analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition | Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.
Uchiyama S, Kawahara K, Hosokawa Y, Fukakusa S, Oki H, Nakamura S, Kojima Y, Noda M, Takino R, Miyahara Y, Maruno T, Kobayashi Y, Ohkubo T, Fukui K., Free PMC Article | 04/23/2016 |
| Results indicate that miR-124-5p may target the tumorigenesis gene, SMC4, which suggests that expression levels of miR-124-5p in plasma and FFPE samples. | Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4.
Jinushi T, Shibayama Y, Kinoshita I, Oizumi S, Jinushi M, Aota T, Takahashi T, Horita S, Dosaka-Akita H, Iseki K., Free PMC Article | 09/26/2015 |
| Knockdown of SMC-4 expression significantly suppressed the proliferation. | Structural maintenance of chromosomes 4 is a predictor of survival and a novel therapeutic target in colorectal cancer.
Feng XD, Song Q, Li CW, Chen J, Tang HM, Peng ZH, Wang XC. | 08/1/2015 |
| SMC4 expression was significantly associated with tumor size, de-differentiation, advanced stages and vascular invasion of the primary liver cancers. | Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer.
Zhou B, Yuan T, Liu M, Liu H, Xie J, Shen Y, Chen P. | 05/11/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. | 12/5/2010 |
| mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL | Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.
Ham MF, Takakuwa T, Rahadiani N, Tresnasari K, Nakajima H, Aozasa K., Free PMC Article | 01/21/2010 |