| Regulation of STAT1 Signaling in Human Pancreatic beta-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes? | Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
Leslie KA, Lekka C, Richardson SJ, Russell MA, Morgan NG. | 10/1/2024 |
| Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma. | Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
García-Domínguez DJ, Hajji N, Sánchez-Molina S, Figuerola-Bou E, de Pablos RM, Espinosa-Oliva AM, Andrés-León E, Terrón-Camero LC, Flores-Campos R, Pascual-Pasto G, Robles MJ, Machado I, Llombart-Bosch A, Magagnoli G, Scotlandi K, Carcaboso ÁM, Mora J, de Álava E, Hontecillas-Prieto L., Free PMC Article | 08/28/2024 |
| HDAC6-mediated deacetylation of FLOT2 maintains stability and tumorigenic function of FLOT2 in nasopharyngeal carcinoma. | HDAC6-mediated deacetylation of FLOT2 maintains stability and tumorigenic function of FLOT2 in nasopharyngeal carcinoma.
Luo C, Wen B, Liu J, Yang W., Free PMC Article | 08/23/2024 |
| HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy. | HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
Zhang T, Tong Y, Zhu R, Liang Y, Zhang J, Hu C, He M, Hu Z, Shen Z, Niu J, Zhang J, Yu Y, Jin B, Lei S, Zeng Z, Wu Y, Cheng Z, Xiao Z, Guo B, Zhao S, Xu G, Pan W, Chen T., Free PMC Article | 05/7/2024 |
| Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage. | Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
Peng C, Wang Y, Hu Z, Chen C., Free PMC Article | 03/12/2024 |
| HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent. | HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent.
Wang L, Shi S, Unterreiner A, Kapetanovic R, Ghosh S, Sanchez J, Aslani S, Xiong Y, Hsu CL, Donovan KA, Farady CJ, Fischer ES, Bornancin F, Matthias P., Free PMC Article | 02/26/2024 |
| HTRA1 promotes EMT through the HDAC6/Ac-alpha-tubulin pathway in human GBM cells. | HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.
Zhao W, Wu Y, Wang S, Zhao F, Liu W, Xue Z, Zhang L, Wang J, Han M, Li X, Huang B., Free PMC Article | 02/15/2024 |
| Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields. | Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Liu L, Liu X, Chen Y, Kong M, Zhang J, Jiang M, Zhou H, Yang J, Chen X, Zhang Z, Wu C, Jiang X, Zhang J. | 01/17/2024 |
| Histone deacetylase 6: at the interface of cancer and neurodegeneration. | Histone deacetylase 6: at the interface of cancer and neurodegeneration.
Pu J, Sharma A, Hou J, Schmidt-Wolf IG. | 12/26/2023 |
| Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells. | Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells.
Mardones C, Navarrete-Munoz C, Armijo ME, Salgado K, Rivas-Valdes F, Gonzalez-Pecchi V, Farkas C, Villagra A, Hepp MI. | 12/20/2023 |
| The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair. | The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, Zhu Q, Liu X, Wang Y, Pei XH, Xu X, Zhang J, Zhu WG., Free PMC Article | 09/26/2023 |
| Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6. | Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6.
Wu X, Zhang X, Liu P, Wang Y. | 09/12/2023 |
| Histone deacetylase 6's function in viral infection, innate immunity, and disease: latest advances. | Histone deacetylase 6's function in viral infection, innate immunity, and disease: latest advances.
Qu M, Zhang H, Cheng P, Wubshet AK, Yin X, Wang X, Sun Y., Free PMC Article | 09/12/2023 |
| Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. | Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1.
Chen J, Lei C, Nie D, Ge H, Li J, Lei C, Wang W. | 07/7/2023 |
| Anti-microbial host factor HDAC6 is antagonised by the influenza A virus through host caspases and viral PA. | Anti-microbial host factor HDAC6 is antagonised by the influenza A virus through host caspases and viral PA.
Hussain M, Ahmed F, Henzeler B, Husain M. | 05/18/2023 |
| HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling. | HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling.
Vong P, Messaoudi K, Jankovsky N, Gomilla C, Demont Y, Caulier A, Jedraszak G, Demagny J, Djordjevic S, Boyer T, Marolleau JP, Rochette J, Ouled-Haddou H, Garçon L., Free PMC Article | 01/28/2023 |
| Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction. | Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction.
Wattanathamsan O, Chantaravisoot N, Wongkongkathep P, Kungsukool S, Chetprayoon P, Chanvorachote P, Vinayanuwattikun C, Pongrakhananon V., Free PMC Article | 01/21/2023 |
| HDAC6: A unique HDAC family member as a cancer target. | HDAC6: A unique HDAC family member as a cancer target.
Kaur S, Rajoria P, Chopra M. | 01/14/2023 |
| HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy. | HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy.
Shi L, Song Z, Li C, Deng F, Xia Y, Huang J, Wu X, Zhu J., Free PMC Article | 01/14/2023 |
| The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6. | The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Tsujimoto K, Jo T, Nagira D, Konaka H, Park JH, Yoshimura SI, Ninomiya A, Sugihara F, Hirayama T, Itotagawa E, Matsuzaki Y, Takaichi Y, Aoki W, Saita S, Nakamura S, Ballabio A, Nada S, Okada M, Takamatsu H, Kumanogoh A., Free PMC Article | 01/14/2023 |
| HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer. | HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
Xu G, Niu L, Wang Y, Yang G, Zhu X, Yao Y, Zhao G, Wang S, Li H., Free PMC Article | 10/29/2022 |
| Modification of cardiac disease by transgenically altered histone deacetylase 6. | Modification of cardiac disease by transgenically altered histone deacetylase 6.
Sanbe A, Inomata Y, Matsushita N, Sawa Y, Hino C, Yamazaki H, Takanohashi K, Takahashi N, Higashio R, Tsumura H, Aoyagi T, Hirose M. | 10/22/2022 |
| HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis. | HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis.
Deng Y, Gao J, Xu G, Yao Y, Sun Y, Shi Y, Hao X, Niu L, Li H. | 10/22/2022 |
| Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility. | Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility.
Fang TJ, Lin CH, Lin YZ, Chiu MH, Li RN, Chan HC, Yeh YT, Yen JH. | 08/6/2022 |
| Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. | Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer.
Dowling CM, Hollinshead KER, Di Grande A, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Düssmann H, O'Connor D, Prehn JHM, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong KK, Letai AG, Chonghaile TN., Free PMC Article | 07/23/2022 |