| Results revealed a genetic association between MUC8 and COPD, and that the specific short minisatellite alleles (2/2) of MUC8-MS5 may be a risk factor for COPD. | Association between the length of the MUC8-minisatellite 5 region and susceptibility to chronic obstructive pulmonary disease (COPD).
Lee SR, Kim WT, Kim TN, Nam JK, Kim WJ, Leem SH. | 10/20/2018 |
| The results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells | Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells.
Song SY, Bae CH, Choi YS, Kim YD. | 11/26/2017 |
| ATP increased P2Y-mediated upregulation of MUC8 expression; however, IL-1alpha significantly decreased the extent to which ATP/P2Y upregulated MUC8 expression. | Silencing of MUC8 by siRNA increases P2Y₂-induced airway inflammation.
Cha HJ, Jung MS, Ahn do W, Choi JK, Ock MS, Kim KS, Yoon JH, Song EJ, Song KS. | 05/16/2015 |
| These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-kappaB signaling pathway in human airway epithelial cells. | Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-κB in human airway epithelial cells.
Song SY, Jung EC, Bae CH, Choi YS, Kim YD., Free PMC Article | 09/13/2014 |
| these results suggest that HMGB1 induces MUC8 expression in a JNK and PI3K/Akt signaling pathway-dependent manner but that HMGB1 acts in an ROS-independent manner. | High-mobility group box-1 protein induces mucin 8 expression through the activation of the JNK and PI3K/Akt signal pathways in human airway epithelial cells.
Kim DE, Min KJ, Kim JS, Kwon TK. | 12/1/2012 |
| MUC1, MUC5B and MUC8, but not MUC2 or MUC5AC, are up-regulated in endometrial adenocarcinomas | Differential expression of MUC genes in endometrial and cervical tissues and tumors.
Hebbar V, Damera G, Sachdev GP., Free PMC Article | 12/1/2012 |
| These findings suggest that IL-1beta, increases ciliogenesis in NHMEE cells and that MUC8 protein may play a role in this process | IL-1beta promotes the ciliogenesis of human middle ear epithelial cells: possible linkage with the expression of mucin gene 8.
Choi JY, Kim JY, Kim CW, Ho JS, Lee KD, Yoo JB, Ahn YE, Yoon JH. | 12/1/2012 |
| cAMP-response element at the -803 region of the MUC8 promoter is an important site of PGE2-induced MUC8 gene expression | Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells.
Cho KN, Choi JY, Kim CH, Baek SJ, Chung KC, Moon UY, Kim KS, Lee WJ, Koo JS, Yoon JH. | 12/1/2012 |
| MUC8 may play an important role in the pathogenesis of sinus hypersecretion in chronic rhinosinusitis. | MUC8 mucin gene up-regulation in chronic rhinosinusitis.
Lee HM, Kim DH, Kim JM, Lee SH, Hwang SJ. | 12/1/2012 |
| Gene induction by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells | Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells.
Song KS, Seong JK, Chung KC, Lee WJ, Kim CH, Cho KN, Kang CD, Koo JS, Yoon JH. | 12/1/2012 |
| Data confirmed an essential role for AP2 alpha in MUC8 gene expression. | AP2alpha is essential for MUC8 gene expression in human airway epithelial cells.
Moon UY, Kim CH, Choi JY, Kim YJ, Choi YH, Yoon HG, Kim H, Yoon JH. | 12/1/2012 |
| SOCS3 negatively regulates IL-1beta-induced MUC8 gene expression. | Interaction of SOCS3 with NonO attenuates IL-1beta-dependent MUC8 gene expression.
Song KS, Kim K, Chung KC, Seol JH, Yoon JH. | 12/1/2012 |
| Reflux laryngitis is associated with down-regulation of mucin gene expression. | Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.
Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N. | 12/1/2012 |