| Comparing the structural dynamics of the human KCNE3 in reconstituted micelle and lipid bilayered vesicle environments. | Comparing the structural dynamics of the human KCNE3 in reconstituted micelle and lipid bilayered vesicle environments.
Campbell C, Faleel FDM, Scheyer MW, Haralu S, Williams PL, Carbo WD, Wilson-Taylor AS, Patel NH, Sanders CR, Lorigan GA, Sahu ID., Free PMC Article | 08/27/2022 |
| Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4 has been reported. | Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4.
Abbott GW., Free PMC Article | 06/2/2018 |
| Structural, computational, biochemical, and electrophysiological studies lead to an atomically explicit integrative structural model of the KCNE3-KCNQ1 complex that explains how KCNE3 induces the constitutive activation of KCNQ1 channel activity, a crucial component in K(+) recycling. | Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR., Free PMC Article | 01/27/2018 |
| Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively. | Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.
Abbott GW., Free PMC Article | 08/26/2017 |
| Based on current evidence from published studies, neither of the two variants from KCNE was significantly associated with the risk of Meniere's disease--{REVIEW} | Variants in the KCNE1 or KCNE3 gene and risk of Ménière's disease: A meta-analysis.
Li YJ, Jin ZG, Xu XR. | 12/17/2016 |
| Data show that voltage-gated potassium channel KCNE3 directly affects the S4 movement in potassium channel KCNQ1. | KCNE3 acts by promoting voltage sensor activation in KCNQ1.
Barro-Soria R, Perez ME, Larsson HP., Free PMC Article | 08/13/2016 |
| KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. | Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis.
Al-Hazza A, Linley J, Aziz Q, Hunter M, Sandle G., Free PMC Article | 06/28/2016 |
| KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation | KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.
Abbott GW., Free PMC Article | 03/19/2016 |
| A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and neurally mediated syncope. | KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram.
Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding WG, Matsuura H, Kurabayashi M, Horie M. | 05/11/2013 |
| Allele frequencies are studied for 11 known variants of KCNE3 gene, of which two (F66F and R83H) are polymorphic but are not associated with chronic tinnitus. | Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus.
Sand PG, Langguth B, Kleinjung T., Free PMC Article | 05/26/2012 |
| The results of this study indicated that Kv7.5 contributes to the spatial regulation. | Targeting of Kv7.5 (KCNQ5)/KCNE channels to surface microdomains of cell membranes.
Roura-Ferrer M, Solé L, Oliveras A, Villarroel A, Comes N, Felipe A. | 02/11/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| 2 of the 8 MiRP2 extracellular domain acidic residues (D54 and D55) are important for KCNQ1-MiRP2 constitutive activation. | A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor.
Choi E, Abbott GW., Free PMC Article | 05/31/2010 |
| data show that SNPs in KCNE1 and KCNE3 are not associated with Meniere disease in Caucasians | Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population.
Campbell CA, Della Santina CC, Meyer NC, Smith NB, Myrie OA, Stone EM, Fukushima K, Califano J, Carey JP, Hansen MR, Gantz BJ, Minor LB, Smith RJ, Campbell CA, Della Santina CC, Meyer NC, Smith NB, Myrie OA, Stone EM, Fukushima K, Califano J, Carey JP, Hansen MR, Gantz BJ, Minor LB, Smith RJ. | 04/12/2010 |
| The KCNE3 protein within the micellesis in monomeric form and acquires mainly alpha-helical conformation. | Bacterial synthesis, purification, and solubilization of membrane protein KCNE3, a regulator of voltage-gated potassium channels.
Goncharuk SA, Shulga AA, Ermolyuk YS, Kuzmichev PK, Sobol VA, Bocharov EV, Chupin VV, Arseniev AS, Kirpichnikov MP. | 03/22/2010 |
| KCNE3 plays a functional role in the modulation of I(to) in the human heart and suggest that mutations in KCNE3 can underlie the development of BrS. | Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.
Delpón E, Cordeiro JM, Núñez L, Thomsen PE, Guerchicoff A, Pollevick GD, Wu Y, Kanters JK, Larsen CT, Hofman-Bang J, Burashnikov E, Christiansen M, Antzelevitch C., Free PMC Article | 01/21/2010 |
| KCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKs potassium channel, KCNQ1. | KCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKs potassium channel.
Kurokawa J, Bankston JR, Kaihara A, Chen L, Furukawa T, Kass RS., Free PMC Article | 01/21/2010 |
| Abnormalities in the KCNE3 gene is a potential genetic risk factor for initiation and/or maintenance of atrial fibrillation. | KCNE3 mutation V17M identified in a patient with lone atrial fibrillation.
Lundby A, Ravn LS, Svendsen JH, Hauns S, Olesen SP, Schmitt N. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesPolymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population.
Campbell CA, Della Santina CC, Meyer NC, Smith NB, Myrie OA, Stone EM, Fukushima K, Califano J, Carey JP, Hansen MR, Gantz BJ, Minor LB, Smith RJ, Campbell CA, Della Santina CC, Meyer NC, Smith NB, Myrie OA, Stone EM, Fukushima K, Califano J, Carey JP, Hansen MR, Gantz BJ, Minor LB, Smith RJ. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.
Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M. No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients.
Tang NL, Chow CC, Ko GT, Tai MH, Kwok R, Yao XQ, Cockram CS. Lack of association of the potassium channel-associated peptide MiRP2-R83H variant with periodic paralysis.
Sternberg D, Tabti N, Fournier E, Hainque B, Fontaine B. | 03/13/2008 |
| Up-regulation and incrased activity of KV3.4 channels and their accessory subunit Mirp2 induced by amyloid peptide are involved in apoptotic neuronal death. | Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.
Pannaccione A, Boscia F, Scorziello A, Adornetto A, Castaldo P, Sirabella R, Taglialatela M, Di Renzo GF, Annunziato L. | 01/21/2010 |
| Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. | Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval.
Mazhari R, Nuss HB, Armoundas AA, Winslow RL, Marbán E., Free PMC Article | 01/21/2010 |
| KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 | KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.
Lundby A, Olesen SP. | 01/21/2010 |
| The authors found MiRP2-R83H in 3 of 321 control subjects and in 5 unaffected related individuals. Provocation of an unaffected carrier with glucose or KCl did not induce weakness. | Periodic paralysis mutation MiRP2-R83H in controls: Interpretations and general recommendation.
Jurkat-Rott K, Lehmann-Horn F. | 01/21/2010 |
| The characterization of a missense mutation in MiRP2 that affects its phosphorylation and consequent interactions with Kv3.4 is reported. | Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis.
Abbott GW, Butler MH, Goldstein SA. | 01/21/2010 |
| The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD. | Ménière's disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3.
Doi K, Sato T, Kuramasu T, Hibino H, Kitahara T, Horii A, Matsushiro N, Fuse Y, Kubo T. | 01/21/2010 |