| Adaptor protein Abelson interactor 1 in homeostasis and disease. | Adaptor protein Abelson interactor 1 in homeostasis and disease.
Petersen M, Dubielecka P., Free PMC Article | 10/8/2024 |
| Circulating miR-30e-3p induces disruption of neurite development in SH-SY5Y cells by targeting ABI1, a novel biomarker for schizophrenia. | Circulating miR-30e-3p induces disruption of neurite development in SH-SY5Y cells by targeting ABI1, a novel biomarker for schizophrenia.
Jin M, Xie M, Liu Y, Song H, Zhang M, Li W, Li X, Jia N, Dong L, Lu Q, Xue F, Yan L, Yu Q. | 08/21/2024 |
| Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers. | Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers.
Lin T, Guo J, Peng Y, Li M, Liu Y, Yu X, Wu N, Yu W., Free PMC Article | 02/2/2024 |
| ABI1-based expression signature predicts breast cancer metastasis and survival. | ABI1-based expression signature predicts breast cancer metastasis and survival.
Regua A, Papp C, Grageda A, Porter BA, Caza T, Bichindaritz I, Krendel M, Sivapiragasam A, Bratslavsky G, Kuznetsov VA, Kotula L., Free PMC Article | 07/30/2022 |
| The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer. | The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer.
Zhang Y, Zhong Z, Li M, Chen J, Lin T, Sun J, Wang D, Mu Q, Su H, Wu N, Liu A, Yu Y, Zhang M, Liu Y, Guo J, Yu W., Free PMC Article | 11/13/2021 |
| Acetylation of Abelson interactor 1 at K416 regulates actin cytoskeleton and smooth muscle contraction. | Acetylation of Abelson interactor 1 at K416 regulates actin cytoskeleton and smooth muscle contraction.
Wang Y, Liao G, Wang R, Tang DD., Free PMC Article | 08/28/2021 |
| RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis. | RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis.
Li Y, Guo X, Xue G, Wang H, Wang Y, Wang W, Yang S, Ni Q, Chen J, Lv L, Zhao Y, Ye M, Zhang L., Free PMC Article | 05/15/2021 |
| PTEN dephosphorylates Abi1 to promote epithelial morphogenesis. | PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
Qi Y, Liu J, Chao J, Greer PA, Li S., Free PMC Article | 03/27/2021 |
| PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1. | PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.
Qi Y, Liu J, Chao J, Scheuerman MP, Rahimi SA, Lee LY, Li S., Free PMC Article | 12/19/2020 |
| Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration. | Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration.
Wang R, Liao G, Wang Y, Tang DD., Free PMC Article | 12/12/2020 |
| ABI1 controls prostate tumor progression and epithelial plasticity through regulation of EMT-WNT pathway | Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.
Nath D, Li X, Mondragon C, Post D, Chen M, White JR, Hryniewicz-Jankowska A, Caza T, Kuznetsov VA, Hehnly H, Jamaspishvili T, Berman DM, Zhang F, Kung SHY, Fazli L, Gleave ME, Bratslavsky G, Pandolfi PP, Kotula L., Free PMC Article | 07/18/2020 |
| CD34(+) hematopoietic progenitors and granulocytes from patients with primary myelofibrosis showed decreased levels of ABI1 transcript as well as increased activity of Src family kinases , STAT3, and NF-kappaB. | Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis.
Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM., Free PMC Article | 08/3/2019 |
| The expression of ABI1 was suppressed by miR-181a/b, and ABI1 was validated as a direct target of miR-181a/b. miR-181a/b were significantly upregulated in aggressive neuroblastoma, which enhanced its tumorigenesis and progression by suppressing the expression of ABI1. | MiR-181a/b induce the growth, invasion, and metastasis of neuroblastoma cells through targeting ABI1.
Liu X, Peng H, Liao W, Luo A, Cai M, He J, Zhang X, Luo Z, Jiang H, Xu L. | 04/27/2019 |
| These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation. | Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.
Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F., Free PMC Article | 03/30/2019 |
| our findings indicated that ABI1 contributes to the development and progression of hepatocellular carcinoma (HCC) as an oncogene and may serve as a valuable prognostic marker for HCC patients. | Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma.
Wang JL, Yan TT, Long C, Cai WW. | 07/22/2017 |
| these data indicate that HCV exploits host Abi1 protein via NS5A to modulate MEK/ERK signaling pathway for its own propagation. | Hepatitis C Virus Nonstructural 5A Protein Interacts with Abelson Interactor 1 and Modulates Epidermal Growth Factor-mediated MEK/ERK Signaling Pathway.
Huynh VT, Lim YS, Tran SC, Pham TM, Nguyen LN, Hwang SB., Free PMC Article | 05/27/2017 |
| Suggest that Abi1 acts as a tumor-promoting gene in epithelial ovarian cancer progression, which may lead to unfavorable prognosis. | Upregulation of Abelson interactor protein 1 predicts tumor progression and poor outcome in epithelial ovarian cancer.
Zhang J, Tang L, Chen Y, Duan Z, Xiao L, Li W, Liu X, Shen L. | 11/21/2015 |
| These results indicate that the alpha4-Abi-1 signaling pathway may mediate acquisition of the drug-resistant phenotype of leukemic cells. | Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia.
Chorzalska A, Salloum I, Shafqat H, Khan S, Marjon P, Treaba D, Schorl C, Morgan J, Bryke CR, Falanga V, Zhao TC, Reagan J, Winer E, Olszewski AJ, Al-Homsi AS, Kouttab N, Dubielecka PM., Free PMC Article | 01/10/2015 |
| Our data indicate that phosphorylated Abi1 contributes to the invasive properties of colorectal cancer. | Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells.
Steinestel K, Brüderlein S, Lennerz JK, Steinestel J, Kraft K, Pröpper C, Meineke V, Möller P., Free PMC Article | 12/20/2014 |
| Abi1 is expressed at the invasive front of colorectal carcinomas and localizes to the leading edge of lamellipodia in cultured colorectal carcinoma cells. | [Abelson interactor 1 (Abi1) in colorectal cancer. From synaptic plasticity to tumor cell migration].
Steinestel K, Gläsle F, Brüderlein S, Steinestel J, Pröpper C, Möller P. | 11/22/2014 |
| Data indicate that Abi1 is activated by the c-Abl-Crk-associated substrate (CAS) pathway, and Abi1 reciprocally controls the activation of its upstream regulator c-Abl. | Role of the adapter protein Abi1 in actin-associated signaling and smooth muscle contraction.
Wang T, Cleary RA, Wang R, Tang DD., Free PMC Article | 09/28/2013 |
| a possible role for Abi1 as a marker for early KRAS mutation in hyperplastic polyps | Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis.
Steinestel K, Brüderlein S, Steinestel J, Märkl B, Schwerer MJ, Arndt A, Kraft K, Pröpper C, Möller P., Free PMC Article | 03/2/2013 |
| Breast tumors expressing high levels of Abi1 are significantly associated with early recurrence and worse survival on multivariate analysis. | Expression of Abl interactor 1 and its prognostic significance in breast cancer: a tissue-array-based investigation.
Wang C, Tran-Thanh D, Moreno JC, Cawthorn TR, Jacks LM, Wang DY, McCready DR, Done SJ. | 09/15/2012 |
| Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis. | E3B1/ABI-1 isoforms are down-regulated in cancers of human gastrointestinal tract.
Baba RA, Bhat HF, Wani LA, Bashir M, Wani MM, Qadri SK, Khanday FA., Free PMC Article | 07/14/2012 |
| The phosphorylation and dephosphorylation cycle of VASP by the Abi-1-bridged mechanism regulates association of VASP with focal adhesions, which may regulate adhesion of Bcr-Abl-transformed leukaemic cells. | Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion.
Maruoka M, Sato M, Yuan Y, Ichiba M, Fujii R, Ogawa T, Ishida-Kitagawa N, Takeya T, Watanabe N. | 03/17/2012 |