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    AKT3 AKT serine/threonine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 10000, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A spectrum of AKT3 activating mutations cause focal malformations of cortical development (FMCDs) in cortical organoids.

    A spectrum of AKT3 activating mutations cause focal malformations of cortical development (FMCDs) in cortical organoids.
    Xu Y, Lu R, Li H, Feng W, Zhao R.

    06/28/2024
    Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.

    Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.
    Corre E, Soum C, Pfeifer R, Bessière C, Dailhau S, Marbœuf C, Meggetto F, Touriol C, Récher C, Bousquet M, Pyronnet S., Free PMC Article

    04/5/2024
    Autocrine Regulation of Interleukin-6 via the Activation of STAT3 and Akt in Cardiac Myxoma Cells.

    Autocrine Regulation of Interleukin-6 via the Activation of STAT3 and Akt in Cardiac Myxoma Cells.
    Jougasaki M, Takenoshita Y, Umebashi K, Yamamoto M, Sudou K, Nakashima H, Sonoda M, Kinjo T., Free PMC Article

    03/13/2024
    All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.

    All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
    Tian LY, Smit DJ, Popova NV, Horn S, Velasquez LN, Huber S, Jücker M., Free PMC Article

    03/13/2024
    Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM2.5-induced inflammatory response in human bronchial epithelial cells.

    Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM(2.5)-induced inflammatory response in human bronchial epithelial cells.
    Li JL, Tan Y, Wang QL, Li CX, Hong JC, Wang HJ, Wu Y, Ni C, Peng XW.

    01/29/2024
    Differential activation of AKT isoforms by growth factors in human myotubes.

    Differential activation of AKT isoforms by growth factors in human myotubes.
    Roberts BM, Geddis AV, Matheny RW Jr., Free PMC Article

    11/13/2023
    Detecting Low-Variant Allele Frequency Mosaic Pathogenic Variants of NF1, TSC2, and AKT3 Genes from Blood in Patients with Neurodevelopmental Disorders.

    Detecting Low-Variant Allele Frequency Mosaic Pathogenic Variants of NF1, TSC2, and AKT3 Genes from Blood in Patients with Neurodevelopmental Disorders.
    Kim SH, Kwon SS, Park MR, Lee HA, Kim JH, Cha J, Kim S, Baek ST, Kim SH, Lee JS, Kim HD, Choi JR, Lee ST, Kang HC.

    08/3/2023
    Downregulation of circ_0024028 inhibits IL-22-induced keratinocyte proliferation and migration by miR-486-3p/AKT3 axis.

    Downregulation of circ_0024028 inhibits IL-22-induced keratinocyte proliferation and migration by miR-486-3p/AKT3 axis.
    Zhang B, Wu S.

    07/25/2023
    circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer.

    circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer.
    Tolomeo D, Traversa D, Venuto S, Ebbesen KK, García Rodríguez JL, Tamma G, Ranieri M, Simonetti G, Ghetti M, Paganelli M, Visci G, Liso A, Kok K, Muscarella LA, Fabrizio FP, Frassanito MA, Lamanuzzi A, Saltarella I, Solimando AG, Fatica A, Ianniello Z, Marsano RM, Palazzo A, Azzariti A, Longo V, Tommasi S, Galetta D, Catino A, Zito A, Mazza T, Napoli A, Martinelli G, Kjems J, Kristensen LS, Vacca A, Storlazzi CT.

    05/12/2023
    Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis.

    Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis.
    Geroldinger-Simić M, Bayati S, Pohjanen E, Sepp N, Nilsson P, Pin E., Free PMC Article

    03/31/2023
    Circ-AKT3 promotes the proliferation and migration of HCC cells via down-regulating microRNA-335 expression.

    Circ-AKT3 promotes the proliferation and migration of HCC cells via down-regulating microRNA-335 expression.
    Dong B, Li H, Wang C, Qian X, Zhang R.

    01/28/2023
    AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope.

    AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope.
    Wainstein E, Maik-Rachline G, Blenis J, Seger R.

    12/17/2022
    LncRNA PVT1 regulates biological function of osteoarthritis cells by regulating miR-497/AKT3 axis.

    LncRNA PVT1 regulates biological function of osteoarthritis cells by regulating miR-497/AKT3 axis.
    Xu J, Fang X, Qin L, Wu Q, Zhan X., Free PMC Article

    12/3/2022
    Cutaneous vascular anomalies associated with a mosaic variant of AKT3: Genetic analysis continues to refine the diagnosis, nomenclature, and classification of vascular anomalies.

    Cutaneous vascular anomalies associated with a mosaic variant of AKT3: Genetic analysis continues to refine the diagnosis, nomenclature, and classification of vascular anomalies.
    Davies OMT, Garzon MC, Frieden IJ, Cottrell CE, Gripp KW, Saneto RP, Shwayder T, Mirzaa GM, Drolet BA., Free PMC Article

    08/27/2022
    N(6)-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424-5p/AKT3 axis.

    N(6)-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424-5p/AKT3 axis.
    Xian J, Shang M, Dai Y, Wang Q, Long X, Li J, Cai Y, Xia C, Peng X.

    03/12/2022
    Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration.

    Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration.
    Luo Y, Zhou Q, Zhu F, Fan L, Bo H, Wang X., Free PMC Article

    02/19/2022
    Circ_0016760 accelerates non-small-cell lung cancer progression through miR-646/AKT3 signaling in vivo and in vitro.

    Circ_0016760 accelerates non-small-cell lung cancer progression through miR-646/AKT3 signaling in vivo and in vitro.
    Chen S, Zhou L, Ran R, Huang J, Zheng Y, Xing M, Cai Y., Free PMC Article

    02/5/2022
    miR-150 and SRPK1 regulate AKT3 expression to participate in LPS-induced inflammatory response.

    miR-150 and SRPK1 regulate AKT3 expression to participate in LPS-induced inflammatory response.
    Yao Y, Wang H, Xi X, Sun W, Ge J, Li P., Free PMC Article

    01/29/2022
    CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.

    CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.
    Shi F, Yang Q, Shen D, Chen J., Free PMC Article

    01/15/2022
    Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis.

    Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis.
    Wang S, Yi M, Zhang X, Zhang T, Jiang L, Cao L, Zhou Y, Fang X.

    01/8/2022
    CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer.

    CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer.
    Ding L, Xie Z.

    12/25/2021
    Long noncoding RNA LINC01224 promotes cell proliferation and inhibits apoptosis by regulating AKT3 expression via targeting miR4855p in endometrial carcinoma.

    Long non‑coding RNA LINC01224 promotes cell proliferation and inhibits apoptosis by regulating AKT3 expression via targeting miR‑485‑5p in endometrial carcinoma.
    Zuo X, Li W, Yan X, Ma T, Ren Y, Hua M, Yang H, Wu H, Zhu H., Free PMC Article

    12/25/2021
    LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.

    LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.
    Ni J, Huang Z, Wang D., Free PMC Article

    12/25/2021
    CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.

    CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.
    Fang X, Huang W, Wu P, Zeng J, Li X.

    11/27/2021
    Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFbeta/CTGF Axis.

    Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis.
    Hinz N, Baranowsky A, Horn M, Kriegs M, Sibbertsen F, Smit DJ, Clezardin P, Lange T, Schinke T, Jücker M., Free PMC Article

    10/23/2021
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