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    ibpB small heat shock protein IbpB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948192, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ibpB
    Official Full Name
    small heat shock protein IbpB
    Primary source
    ECOCYC:EG11535
    Locus tag
    b3686
    See related
    ASAP:ABE-0012054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3678; hslS; htpE
    Summary
    RpoH regulon. [More information is available at EcoGene: EG11535]. IbpB is a small heat shock protein that binds to aggregated proteins and inclusion bodies formed during heterologous protein expression . [More information is available at EcoCyc: EG11535].
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    Genomic context

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    Sequence:
    NC_000913.3 (3866469..3866897, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative PTS enzyme II component GlvC Neighboring gene putative DNA-binding transcriptional regulator YidP Neighboring gene putative transport protein YidE Neighboring gene small heat shock protein IbpA Neighboring gene DUF1375 domain-containing putative lipoprotein YidQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of the small heat shock protein IbpB from Escherichia coli. Shearstone JR, et al. J Biol Chem, 1999 Apr 9. PMID 10187768
    2. The essential role of the flexible termini in the temperature-responsiveness of the oligomeric state and chaperone-like activity for the polydisperse small heat shock protein IbpB from Escherichia coli. Jiao W, et al. J Mol Biol, 2005 Apr 8. PMID 15769476
    3. Overexpression of IbpB enhances production of soluble active Streptomyces olivaceovirdis XynB in Escherichia coli. Su X, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19825366
    4. Physical map and dynamics of the chaperone network in Escherichia coli. Kumar M, et al. Mol Microbiol, 2012 May. PMID 22463727
    5. Small heat shock proteins, IbpA and IbpB, are involved in resistances to heat and superoxide stresses in Escherichia coli. Kitagawa M, et al. FEMS Microbiol Lett, 2000 Mar 15. PMID 10713416

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IbpAB small heat shock proteins are not host factors for bacteriophage varphiX174 replication.
      Title: IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication.
    2. An RNA thermometer in its 5' untranslated region, forming a secondary structure upstream of ibpB is functional in vitro but not in vivo, suggesting downregulation of ibpB expression in the presence of IbpA.
      Title: Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon.
    3. The authors report that IbpA and IbpB, the sHSPs of Escherichia coli, are substrates for the AAA+ Lon protease.
      Title: The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.
    4. The lack of IbpAB proteins in E. coli cells results in endogenous oxidative stress and overproduction of extracellular indole, which inhibits the growth of the biofilm at the air-liquid interface.
      Title: Escherichia coli heat-shock proteins IbpA and IbpB affect biofilm formation by influencing the level of extracellular indole.
    5. N-terminus verified by Edman degradation on complete protein
      Title: Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli.
    6. the flexible termini appear to be essential for small heat shock protein IbpB to generate various temperature-responsive oligomers, which exhibit various levels of chaperone-like activities, by interlinking or separating the dimer building blocks
      Title: The essential role of the flexible termini in the temperature-responsiveness of the oligomeric state and chaperone-like activity for the polydisperse small heat shock protein IbpB from Escherichia coli.
    7. IbpA cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state
      Title: The small heat shock protein IbpA of Escherichia coli cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stress response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small heat shock protein IbpB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3866469..3866897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418141.2 small heat shock protein IbpB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418141.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z4C5, A0A454A9D8, A0A829KXZ0, A0AA36L1X3, A0AAN3LMK9, A0AAN3SE96, A0AAN4HVS4, C3SLR7, D3H311, E1JD44, Q1R4Q0
      Conserved Domains (1) summary
      PRK11597
      Location:1 → 142
      PRK11597; heat shock chaperone IbpB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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