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    scpB methylmalonyl-CoA decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947408, updated on 10-Oct-2024

    Summary

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    Official Symbol
    scpB
    Official Full Name
    methylmalonyl-CoA decarboxylase
    Primary source
    ECOCYC:G7516
    Locus tag
    b2919
    See related
    ASAP:ABE-0009581
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2915; ygfG
    Summary
    Part of a four gene operon encoding enzymes converting succinate to propionate. [More information is available at EcoGene: EG12972]. Methylmalonyl-CoA decarboxylase is a biotin-independent enzyme that catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. [More information is available at EcoCyc: G7516].
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    Genomic context

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    Sequence:
    NC_000913.3 (3063993..3064778)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator ArgP Neighboring gene methylmalonyl-CoA mutase Neighboring gene methylmalonyl-CoA mutase-interacting GTPase YgfD Neighboring gene propionyl-CoA:succinate CoA transferase Neighboring gene putative DNA-binding transcriptional regulator YgfI Neighboring gene DUF541 domain-containing protein YggE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli. Benning MM, et al. Biochemistry, 2000 Apr 25. PMID 10769118
    2. Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium. Aldor IS, et al. Appl Environ Microbiol, 2002 Aug. PMID 12147480, Free PMC Article
    3. Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Haller T, et al. Biochemistry, 2000 Apr 25. PMID 10769117
    4. Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity. Hamed RB, et al. Cell Mol Life Sci, 2008 Aug. PMID 18470480, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxy-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl/ethyl malonyl-CoA decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl/ethyl malonyl-CoA decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methylmalonyl-CoA decarboxylase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3063993..3064778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417394.4 methylmalonyl-CoA decarboxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417394.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3JI77, A0A1X3I2Q4, A0A1X3JDG6, A0AAP7VU31, C3SVK2
      Conserved Domains (1) summary
      PRK11423
      Location:1 → 261
      PRK11423; methylmalonyl-CoA decarboxylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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