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    SMN1 Smn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856609, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SMN1
    Official Full Name
    Smn1p
    Primary source
    SGD:S000001245
    Locus tag
    YHR202W
    See related
    AllianceGenome:SGD:S000001245; FungiDB:YHR202W; VEuPathDB:YHR202W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 5'-nucleotidase activity. Involved in NAD catabolic process. Located in cytosol. Is active in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SMN1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (502388..504196)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPN10 Neighboring gene exopolyphosphatase Neighboring gene ribosomal 40S subunit protein S4B Neighboring gene alpha-1,2-mannosidase MNL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase. Cohen N, et al. J Mol Biol, 2022 Apr 15. PMID 35123996, Free PMC Article
    2. Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae. Pinson B, et al. J Biol Chem, 2004 Aug 20. PMID 15194704
    3. A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic data. Aucher W, et al. Mol Cell Proteomics, 2010 Dec. PMID 20733106, Free PMC Article
    4. Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae. Terashima H, et al. Curr Genet, 2002 Feb. PMID 11935221
    5. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase.
      Title: A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smn1p
    NP_012072.3
    • Putative AMP hydrolase; secreted protein proposed to function as an adenosine monophosphatase in NAD+ degradation, via nucleoside salvage pathway that converts NAD+ to AMP and adenosine; overexpression results in adenosine accumulation and reduced levels of NAD+, deletion results in increased NAD+ and NADH; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; similar to human NT5E/CD73 gene involved in cancer progression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      502388..504196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179333.3 → NP_012072.3  TPA: Smn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012072.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLF1, P38887
      UniProtKB/TrEMBL
      A6ZTA9, B3LSW3, C8ZA03, N1P320
      Conserved Domains (1) summary
      cd07407
      Location:39 → 325
      MPP_YHR202W_N; Saccharomyces cerevisiae YHR202W and related proteins, N-terminal metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38887.1

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