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    NOP10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856471, updated on 22-Aug-2024

    Summary

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    Official Symbol
    NOP10
    Primary source
    FungiDB:YHR072W-A
    Locus tag
    YHR072W-A
    See related
    SGD:S000007455; AllianceGenome:SGD:S000007455; VEuPathDB:YHR072W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in cleavage involved in rRNA processing; rRNA pseudouridine synthesis; and snRNA pseudouridine synthesis. Located in nucleolus. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (241664..241840)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene lanosterol synthase ERG7 Neighboring gene oxysterol-binding protein related protein OSH3 Neighboring gene glutamine-dependent NAD(+) synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nop10 is a conserved H/ACA snoRNP molecular adaptor. Reichow SL, et al. Biochemistry, 2008 Jun 10. PMID 18473479
    2. Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA. Khanna M, et al. RNA, 2006 Jan. PMID 16373493, Free PMC Article
    3. Base-pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins. Kelly EK, et al. RNA, 2019 Oct. PMID 31311819, Free PMC Article
    4. Increasing the Depth of Mass-Spectrometry-Based Structural Analysis of Protein Complexes through the Use of Multiple Cross-Linkers. Ding YH, et al. Anal Chem, 2016 Apr 19. PMID 27010980
    5. Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs. Henras AK, et al. RNA, 2004 Nov. PMID 15388873, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    snoRNP complex protein NOP10
    NP_058135.1
    • Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      241664..241840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184438.1 → NP_058135.1  TPA: snoRNP complex protein NOP10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_058135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL22, Q6Q547
      UniProtKB/TrEMBL
      A6ZSX9, B3LSJ0, C7GWT4, C8Z9L3, G2WFE5, N1P2N0
      Conserved Domains (1) summary
      pfam04135
      Location:4 → 52
      Nop10p; Nucleolar RNA-binding protein, Nop10p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q547.1

    Gene LinkOut

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