RIM101 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RIM101
Primary source: FungiDB:YHL027W
Locus tag: YHL027W
See related: SGD:S000001019; AllianceGenome:SGD:S000001019; VEuPathDB:YHL027W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RIM1
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to alkaline pH; cellular response to anoxia; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RIM101 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (51111..52988)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pH-sensing Rim101 pathway regulates cell size in budding yeast.
Title: The pH-sensing Rim101 pathway regulates cell size in budding yeast.
The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein.
Title: The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein.
Rapid turnover of transcription factor Rim101 confirms a flexible adaptation mechanism against environmental stress in Saccharomyces cerevisiae.
Title: Rapid turnover of transcription factor Rim101 confirms a flexible adaptation mechanism against environmental stress in Saccharomyces cerevisiae.
The pH-sensing Rim101 pathway positively regulates the transcriptional expression of the calcium pump gene PMR1 to affect calcium sensitivity in budding yeast.
Title: The pH-sensing Rim101 pathway positively regulates the transcriptional expression of the calcium pump gene PMR1 to affect calcium sensitivity in budding yeast.
The toxic effects of DG are linked to glucose metabolism and require a functional Rim101 signaling cascade involving the Rim21-dependent sensing complex and the activation of a calpain-like protease. The Rim101 cascade is an established pathway that triggers a transcriptional response to alkaline or lipid stress.
Title: Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity.
Data suggest a model where binding of DNA to a dimer mitochondrial single-stranded DNA binding protein Rim1 (Rim1) induces tetramerization, modulated by the ability of the second dimer to interact with ssDNA.
Title: The mitochondrial single-stranded DNA binding protein from S. cerevisiae, Rim1, does not form stable homo-tetramers and binds DNA as a dimer of dimers.
These results suggest that the Rim101 pathway is important for the adaptation to ER stress by compensating for alterations in plasma membrane lipid asymmetry induced by ER stress.
Title: The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane.
We conclude that summation operator1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background .
Title: A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity.
These results show that, in response to salt stress, a functional Rim complex via specific ESCRT interactions is required for the proper accumulation of the Ena1 protein, but not induction of the ENA1 gene.
Title: A functional Rim101 complex is required for proper accumulation of the Ena1 Na+-ATPase protein in response to salt stress in Saccharomyces cerevisiae.
A role of Rim101 in modulation of vacuolar acidity necessary for selenite detoxification is discovered.
Title: The PacC-family protein Rim101 prevents selenite toxicity in Saccharomyces cerevisiae by controlling vacuolar acidification.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in ascospore formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to alkaline pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to anoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of division septum assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkaline-responsive transcriptional regulator RIM101

NP_011836.1

Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression; involved in cell wall assembly; plays role in lager yeast flocculation under brewing conditions; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

51111..52988

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179107.1 → NP_011836.1 TPA: alkaline-responsive transcriptional regulator RIM101 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011836.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKU1, P33400

UniProtKB/TrEMBL

A6ZSM3, C8ZA37

Conserved Domains (2) summary

COG5048
Location:41 → 571

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:151 → 171

ZF_C2H2; C2H2 Zn finger [structural motif]