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    KAP120 Kap120p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855978, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KAP120
    Official Full Name
    Kap120p
    Primary source
    SGD:S000006046
    Locus tag
    YPL125W
    See related
    AllianceGenome:SGD:S000006046; FungiDB:YPL125W; VEuPathDB:YPL125W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPH2
    Summary
    Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See KAP120 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (313388..316486)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histone H1 Neighboring gene Nan1p Neighboring gene Spc29p Neighboring gene ribonuclease T2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway. Chattopadhyay S, et al. Nat Commun, 2022 Nov 23. PMID 36418294, Free PMC Article
    2. Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid. Butterfield-Gerson KL, et al. J Virol, 2006 Feb. PMID 16439536, Free PMC Article
    3. Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Kim KY, et al. Mol Biol Cell, 2010 May 1. PMID 20219973, Free PMC Article
    4. Nuclear import of ho endonuclease utilizes two nuclear localization signals and four importins of the ribosomal import system. Bakhrat A, et al. J Biol Chem, 2006 May 5. PMID 16507575
    5. Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus. Süel KE, et al. J Biol Chem, 2009 Jun 5. PMID 19366694, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KAP120 functions as a nuclear import receptor for ribosome assembly factor RPF1.
      Title: Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kap120p
    NP_015200.1
    • Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      313388..316486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183939.1 → NP_015200.1  TPA: Kap120p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015200.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3P2, Q02932
      UniProtKB/TrEMBL
      B5VT40, C7GJ79, C8ZIQ4, N1NX29
      Conserved Domains (1) summary
      COG5657
      Location:8 → 1023
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02932.1

    Gene LinkOut

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