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    YIM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855183, updated on 22-Aug-2024

    Summary

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    Official Symbol
    YIM1
    Primary source
    FungiDB:YMR152W
    Locus tag
    YMR152W
    See related
    SGD:S000004760; AllianceGenome:SGD:S000004760; VEuPathDB:YMR152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol dehydrogenase [NAD(P)+] activity. Involved in cellular response to DNA damage stimulus. Located in lipid droplet. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (563096..564193)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase Neighboring gene endopeptidase catalytic subunit IMP1 Neighboring gene FG-nucleoporin NUP53 Neighboring gene Rim13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YMR152W from Saccharomyces cerevisiae encoding a novel aldehyde reductase for detoxification of aldehydes derived from lignocellulosic biomass. Ouyang Y, et al. J Biosci Bioeng, 2021 Jan. PMID 32967812
    2. Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Birrell GW, et al. Proc Natl Acad Sci U S A, 2002 Jun 25. PMID 12077312, Free PMC Article
    3. Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. Athenstaedt K, et al. J Bacteriol, 1999 Oct. PMID 10515935, Free PMC Article
    4. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Currie E, et al. J Lipid Res, 2014 Jul. PMID 24868093, Free PMC Article
    5. Growth-Regulated Hsp70 Phosphorylation Regulates Stress Responses and Prion Maintenance. Kao CH, et al. Mol Cell Biol, 2020 May 28. PMID 32205407, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yim1p
    NP_013872.1
    • Aldehyde reductase; involved in detoxification of lignocellulose-derived aldehydes; catalyzes the reduction of furan, aliphatic and aromatic aldehydes using either NADH or NADPH as co-factor; membrane of the quinone oxidoreductase subfamily of the medium-chain dehydrogenase/reductase family; null mutant displays sensitivity to DNA damaging agents; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      563096..564193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182654.1 → NP_013872.1  TPA: Yim1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013872.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZML0, D6VZX3, P28625
      Conserved Domains (1) summary
      cd08247
      Location:8 → 364
      AST1_like; AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28625.2

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