TRM9 tRNA (carboxymethyluridine(34)-5-O)-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRM9
Official Full Name: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase
Primary source: SGD:S000004476
Locus tag: YML014W
See related: AllianceGenome:SGD:S000004476; FungiDB:YML014W; VEuPathDB:YML014W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KTI1
Summary: Enables tRNA (uridine) methyltransferase activity. Involved in regulation of translational elongation; tRNA methylation; and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 71. Orthologous to several human genes including ALKBH8 (alkB homolog 8, tRNA methyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See TRM9 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (243225..244064)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, these results suggest that Trm9-catalyzed tRNA modifications play a significant role in regulating protein expression within the cell.
Title: Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation.
Trm9-catalyzed tRNA modifications promote fidelity during the translation of specific transcripts.
Title: Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (uridine) methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in macromolecule modification	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA wobble uridine modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase

NP_013698.1

EC 2.1.1.229

tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

243225..244064

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182372.1 → NP_013698.1 TPA: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013698.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZG0, P49957

UniProtKB/TrEMBL

A6ZM48, B5VPB2, C7GLD2, C8ZEJ0, G2WK38, N1NX41

Conserved Domains (1) summary

pfam13649
Location:51 → 138

Methyltransf_25; Methyltransferase domain