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    AIM25 Aim25p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853563, updated on 2-Nov-2024

    Summary

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    Official Symbol
    AIM25
    Official Full Name
    Aim25p
    Primary source
    SGD:S000003861
    Locus tag
    YJR100C
    See related
    AllianceGenome:SGD:S000003861; FungiDB:YJR100C; VEuPathDB:YJR100C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLM35
    Summary
    Predicted to enable phospholipid scramblase activity. Involved in cellular response to heat; cellular response to oxidative stress; and negative regulation of autophagy of mitochondrion. Located in mitochondrion. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See AIM25 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (616351..617334, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ubiquitin-specific protease YUH1 Neighboring gene tRNA-Leu Neighboring gene mitochondrial 37S ribosomal protein RSM26

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. Kasukabe T, et al. Blood, 1997 Apr 15. PMID 9108418
    2. Slm35 links mitochondrial stress response and longevity through TOR signaling pathway. Aguilar-Lopez JL, et al. Aging (Albany NY), 2016 Dec 2. PMID 27922823, Free PMC Article
    3. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article
    4. A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Louie RJ, et al. Genome Med, 2012 Dec 27. PMID 23270647, Free PMC Article
    5. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aim25p
    NP_012634.3
    • Mitochondria hypothetical protein; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      616351..617334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181758.3 → NP_012634.3  TPA: Aim25p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012634.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR9, P47140
      UniProtKB/TrEMBL
      A6ZQ56, B3LQI5, B5VLP7, C7GMA7, C8ZBP7, G2WHA3, N1P175
      Conserved Domains (1) summary
      pfam03803
      Location:59 → 310
      Scramblase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47140.1

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