RPC17 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RPC17
Primary source: FungiDB:YJL011C
Locus tag: YJL011C
See related: SGD:S000003548; AllianceGenome:SGD:S000003548; VEuPathDB:YJL011C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. Located in cytosol and nucleus. Part of RNA polymerase III complex. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.
Title: Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.
Crystal structure of subunit C17 is determined.
Title: Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to RNA polymerase III activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase III promoter	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012523.2

RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia

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The following sections contain reference sequences that belong to a specific genome build. Explain