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    NSA1 ribosome biosynthesis protein NSA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852767, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NSA1
    Official Full Name
    ribosome biosynthesis protein NSA1
    Primary source
    SGD:S000003079
    Locus tag
    YGL111W
    See related
    AllianceGenome:SGD:S000003079; FungiDB:YGL111W; VEuPathDB:YGL111W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ribosomal large subunit biogenesis. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NSA1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (299978..301369)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sld3p Neighboring gene TATA-binding protein-associated factor TAF6 Neighboring gene Cue3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae. Lo YH, et al. J Vis Exp, 2018 Jan 10. PMID 29364241, Free PMC Article
    2. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Lo YH, et al. Structure, 2017 May 2. PMID 28416111, Free PMC Article
    3. Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae. Castle CD, et al. Nucleic Acids Res, 2013 Jan. PMID 23175604, Free PMC Article
    4. Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits. Dembowski JA, et al. Nucleic Acids Res, 2013 Sep. PMID 23788678, Free PMC Article
    5. Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway. Panse VG, et al. Traffic, 2006 Oct. PMID 16978391, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rix7 is required for the release of Nsa1 from a discrete preribosomal particle, thereby triggering the progression of 60S ribosome biogenesis.
      Title: The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome biosynthesis protein NSA1
    NP_011404.1
    • Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      299978..301369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180976.1 → NP_011404.1  TPA: ribosome biosynthesis protein NSA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU36, P53136
      UniProtKB/TrEMBL
      C7GM05, G2WDZ0, N1P3H5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53136.1

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