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    SPC110 Spc110p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851957, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPC110
    Official Full Name
    Spc110p
    Primary source
    SGD:S000002764
    Locus tag
    YDR356W
    See related
    AllianceGenome:SGD:S000002764; FungiDB:YDR356W; VEuPathDB:YDR356W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NUF1; XCM1
    Summary
    Enables calmodulin binding activity. A structural constituent of cytoskeleton. Involved in several processes, including gamma-tubulin complex localization to nuclear side of mitotic spindle pole body; karyogamy involved in conjugation with cellular fusion; and positive regulation of microtubule nucleation. Located in central plaque of spindle pole body; inner plaque of spindle pole body; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SPC110 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1186107..1188941)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene thioredoxin-disulfide reductase TRR1 Neighboring gene anthranilate phosphoribosyltransferase Neighboring gene Cnl1p Neighboring gene ubiquitin-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an Spc110p-related protein in vertebrates. Tassin AM, et al. J Cell Sci, 1997 Oct. PMID 9372442
    2. Identification and characterization of the KlCMD1 gene encoding Kluyveromyces lactis calmodulin. Rayner TF, et al. Yeast, 1998 Jun 30. PMID 9818725
    3. The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeleton. Mirzayan C, et al. J Cell Biol, 1992 Mar. PMID 1541631, Free PMC Article
    4. A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated. Kilmartin JV, et al. J Cell Biol, 1993 Dec. PMID 7503995, Free PMC Article
    5. The Saccharomyces cerevisiae spindle pole body is a dynamic structure. Yoder TJ, et al. Mol Biol Cell, 2003 Aug. PMID 12925780, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit.
      Title: Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamma-tubulin complex localization to nuclear side of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-tubulin complex localization to nuclear side of mitotic spindle pole body IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in central plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in inner plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc110p
    NP_010643.3
    • Inner plaque spindle pole body (SPB) component; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; ortholog of human pericentrin (kendrin)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1186107..1188941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180664.3 → NP_010643.3  TPA: Spc110p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010643.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LFU6, C8Z5R8, D6VSY5, P32380
      UniProtKB/TrEMBL
      B5VGN7, N1P705
      Conserved Domains (2) summary
      TIGR02168
      Location:196 → 793
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18520
      Location:893 → 944
      Spc110_C; Spindle pole body component 110 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32380.1

    Gene LinkOut

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