TSC13 trans-2-enoyl-CoA reductase (NADPH) TSC13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TSC13
Official Full Name: trans-2-enoyl-CoA reductase (NADPH) TSC13
Primary source: SGD:S000002173
Locus tag: YDL015C
See related: AllianceGenome:SGD:S000002173; FungiDB:YDL015C; VEuPathDB:YDL015C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables oxidoreductase activity. Involved in very long-chain fatty acid metabolic process. Located in endoplasmic reticulum membrane. Used to study non-syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14 and catecholaminergic polymorphic ventricular tachycardia 3. Orthologous to several human genes including TECRL (trans-2,3-enoyl-CoA reductase like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TSC13 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (426002..426934, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases.
Title: Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases.
Highly conserved domains of the Tsc13p proteins that are likely to be important for enzymatic activity lie on the cytosolic face of the endoplasmic reticulum, possibly partially embedded within the membrane.
Title: A six-membrane-spanning topology for yeast and Arabidopsis Tsc13p, the enoyl reductases of the microsomal fatty acid elongating system.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables very-long-chain enoyl-CoA reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: trans-2-enoyl-CoA reductase (NADPH) TSC13

NP_010269.1

EC 1.3.1.93

Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

426002..426934 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180074.1 → NP_010269.1 TPA: trans-2-enoyl-CoA reductase (NADPH) TSC13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010269.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRX4, Q99190

UniProtKB/TrEMBL

A6ZXV3, B3LGS2, B5VFP8, C7GW63, C8Z4Q4, G2WCE0, N1P681

Conserved Domains (2) summary

PLN02560
Location:1 → 297

PLN02560; enoyl-CoA reductase

pfam02544
Location:154 → 310

Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase