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    LAM6 Lam6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850761, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LAM6
    Official Full Name
    Lam6p
    Primary source
    SGD:S000004062
    Locus tag
    YLR072W
    See related
    AllianceGenome:SGD:S000004062; FungiDB:YLR072W; VEuPathDB:YLR072W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LTC1
    Summary
    Enables sterol transfer activity. Involved in intracellular sterol transport. Located in mitochondria-associated endoplasmic reticulum membrane contact site; nucleus-vacuole junction; and vacuole-mitochondrion membrane contact site. Orthologous to human GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See LAM6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (278862..280943)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene D-xylulose reductase XYL2 Neighboring gene Rgr1p Neighboring gene Rfu1p Neighboring gene Bud20p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites. Tong J, et al. Proc Natl Acad Sci U S A, 2018 Jan 30. PMID 29339490, Free PMC Article
    2. Glucose restriction drives spatial reorganization of mevalonate metabolism. Rogers S, et al. Elife, 2021 Apr 7. PMID 33825684, Free PMC Article
    3. A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport. Gatta AT, et al. Elife, 2015 May 22. PMID 26001273, Free PMC Article
    4. The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria. Koch C, et al. EMBO Rep, 2024 Apr. PMID 38565738, Free PMC Article
    5. Lam6 Regulates the Extent of Contacts between Organelles. Elbaz-Alon Y, et al. Cell Rep, 2015 Jul 7. PMID 26119743, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sterol transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lam6p
    NP_013173.1
    • Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      278862..280943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181959.1 → NP_013173.1  TPA: Lam6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY73, Q08001
      UniProtKB/TrEMBL
      G2WIR4, N1NZ57
      Conserved Domains (2) summary
      cd13220
      Location:175 → 265
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:406 → 556
      DUF4782; Domain of unknown function (DUF4782)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08001.1

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