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    GSY1 glycogen (starch) synthase GSY1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850569, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GSY1
    Official Full Name
    glycogen (starch) synthase GSY1
    Primary source
    SGD:S000001911
    Locus tag
    YFR015C
    See related
    AllianceGenome:SGD:S000001911; FungiDB:YFR015C; VEuPathDB:YFR015C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in cardiovascular system disease and glycogen storage disease. Orthologous to human GYS1 (glycogen synthase 1) and GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GSY1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (174265..176391, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Ioc3p Neighboring gene calmodulin-dependent protein kinase CMK1 Neighboring gene Aip5p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of the GSY1 gene encoding yeast glycogen synthase and evidence for the existence of a second gene. Farkas I, et al. J Biol Chem, 1990 Dec 5. PMID 2123485
    2. Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled. Farkas I, et al. J Biol Chem, 1991 Aug 25. PMID 1908457
    3. Purification and characterization of glycogen synthase from a glycogen-deficient strain of Saccharomyces cerevisiae. Peng ZY, et al. J Biol Chem, 1990 Aug 15. PMID 2116410
    4. Yeast glycogen synthetase in the glucose 6-phosphate-dependent form. II. The effect of proteolysis. Huang KP, et al. J Biol Chem, 1974 Jun 25. PMID 4366243
    5. Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen. Baskaran S, et al. J Biol Chem, 2011 Sep 30. PMID 21835915, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glycogen (starch) synthase GSY1
    NP_116670.1
    • Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      174265..176391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179980.1 → NP_116670.1  TPA: glycogen (starch) synthase GSY1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTP6, P23337
      UniProtKB/TrEMBL
      A7A253, N1PA28
      Conserved Domains (1) summary
      pfam05693
      Location:12 → 683
      Glycogen_syn; Glycogen synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23337.3

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