LAM5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: LAM5
Primary source: FungiDB:YFL042C
Locus tag: YFL042C
See related: SGD:S000001852; AllianceGenome:SGD:S000001852; VEuPathDB:YFL042C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LTC2; YFL043C
Summary: Predicted to enable sterol transfer activity. Predicted to be involved in intracellular sterol transport. Located in mitochondria-associated endoplasmic reticulum membrane and nucleus-vacuole junction. Orthologous to several human genes including GRAMD1A (GRAM domain containing 1A) and GRAMD1B (GRAM domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular sterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sterol transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-plasma membrane contact site	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus-vacuole junction	IDA Inferred from Direct Assay more info	PubMed
located_in organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_116611.1

Putative sterol transfer protein; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; localizes to membrane contact sites throughout the cell, including nucleus-vacuole junctions and ER-mitochondrial contact sites

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The following sections contain reference sequences that belong to a specific genome build. Explain