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    CMT1 chromomethylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844413, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CMT1
    Official Full Name
    chromomethylase 1
    Primary source
    TAIR:AT1G80740
    Locus tag
    AT1G80740
    See related
    Araport:AT1G80740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    chromomethylase 1; CHROMOMETHYLASE 1; DMT4; DNA METHYLTRANSFERASE 4; F23A5.9; F23A5_9
    Summary
    ecotype Kl-0 chromomethylase (CMT1). A plant line expressing an RNAi construct directed against DMT4 has reduced agrobacterium-mediated tumor formation.
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    Genomic context

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    See CMT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Sequence:
    Chromosome: 1; NC_003070.9 (30342394..30347048)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Mitochondrial glycoprotein family protein Neighboring gene zinc-finger protein 1 Neighboring gene Transcription factor TFIIIC, tau55-related protein Neighboring gene Ribosomal protein L30/L7 family protein Neighboring gene NOD26-like intrinsic protein 6;1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis. Zhang B, et al. Mol Plant, 2018 Jul 2. PMID 29734003
    2. CMT3 and SUVH4/KYP silence the exonic Evelknievel retroelement to allow for reconstitution of CMT1 mRNA. Yadav NS, et al. Epigenetics Chromatin, 2018 Nov 16. PMID 30446008, Free PMC Article
    3. The Plastid Envelope CHLOROPLAST MANGANESE TRANSPORTER1 Is Essential for Manganese Homeostasis in Arabidopsis. Eisenhut M, et al. Mol Plant, 2018 Jul 2. PMID 29734002
    4. RNAi-mediated gene silencing reveals involvement of Arabidopsis chromatin-related genes in Agrobacterium-mediated root transformation. Crane YM, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17827277, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CMT1 is expressed primarily in green tissues, and its encoded product is localized in the inner envelope membrane of the chloroplast. Disruption of CMT1 in the T-DNA insertional mutant cmt1-1 resulted in stunted plant growth, defective thylakoid stacking, and severe reduction of photosystem II complexes and photosynthetic activity.
      Title: Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis.
    2. The cmt1 mutant is severely suppressed in growth, chloroplast ultrastructure, and PSII activity owing to a decrease in the amounts of pigments and thylakoid membrane proteins. The importance of CMT1 for chloroplast Mn homeostasis is demonstrated by the significant reduction in chloroplast Mn concentrations in cmt1-1, which exhibited reduced Mn binding in PSII complexes.
      Title: The Plastid Envelope CHLOROPLAST MANGANESE TRANSPORTER1 Is Essential for Manganese Homeostasis in Arabidopsis.
    3. The role of Evelknievel retroelement in the reconstitution of CMT1 mRNA.
      Title: CMT3 and SUVH4/KYP silence the exonic Evelknievel retroelement to allow for reconstitution of CMT1 mRNA.
    Submit: New GeneRIF Correction

    General gene information

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    NM_106722.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-mediated transformation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    chromomethylase 1
    NP_565245.1
    • chromomethylase 1 (CMT1); FUNCTIONS IN: chromatin binding, DNA binding; INVOLVED IN: DNA mediated transformation, DNA methylation; LOCATED IN: chromatin, nucleus; CONTAINS InterPro DOMAIN/s: Chromo domain subgroup (InterPro:IPR017984), DNA methylase, C-5 cytosine-specific (InterPro:IPR001525), Chromo domain-like (InterPro:IPR016197), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), Chromo domain (InterPro:IPR000953); BEST Arabidopsis thaliana protein match is: chromomethylase 3 (TAIR:AT1G69770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30342394..30347048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106722.2 → NP_565245.1  chromomethylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49137, O49138, O49139, O49141, O50057, O50073, Q38940, Q7G196
      UniProtKB/TrEMBL
      A0A654EQU1
      Conserved Domains (3) summary
      cd04716
      Location:78 → 196
      BAH_plantDCM_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases (DCM) from plants. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects ...
      cd18635
      Location:338 → 394
      CD_CMT3_like; chromodomain of chromomethylase 3, and similar proteins
      cl17173
      Location:412 → 760
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49139.2

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