SMT3 sterol methyltransferase 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SMT3
Official Full Name: sterol methyltransferase 3
Primary source: TAIR:AT1G76090
Locus tag: AT1G76090
See related: Araport:AT1G76090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: sterol methyltransferase 3
Summary: Encodes S-adenosyl-methionine-sterol-C-methyltransferase, an enzyme in the sterol biosynthetic pathway.
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Genomic context

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See SMT3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (28550202..28551836, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SMT3 is functionally redundant with SMT2. Mutation in both SMT2 and SMT3 causes extreme alteration in sterol composition.
Title: The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_106258.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 24-methylenesterol C-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sterol 24-C-methyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	TAS Traceable Author Statement more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: sterol methyltransferase 3

NP_177736.1

sterol methyltransferase 3 (SMT3); CONTAINS InterPro DOMAIN/s: Sterol methyltransferase C-terminal (InterPro:IPR013705), Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: sterol methyltransferase 2 (TAIR:AT1G20330.1); Has 10191 Blast hits to 10184 proteins in 2043 species: Archae - 312; Bacteria - 6392; Metazoa - 125; Fungi - 424; Plants - 648; Viruses - 0; Other Eukaryotes - 2290 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

28550202..28551836 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106258.4 → NP_177736.1 sterol methyltransferase 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177736.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23655, Q94JS4

UniProtKB/TrEMBL

A0A178WGT2, A0A5S9WUS2

Conserved Domains (2) summary

PLN02244
Location:77 → 355

PLN02244; tocopherol O-methyltransferase

pfam08498
Location:292 → 354

Sterol_MT_C; Sterol methyltransferase C-terminal