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    SBH1 sphingoid base hydroxylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843300, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SBH1
    Official Full Name
    sphingoid base hydroxylase 1
    Primary source
    TAIR:AT1G69640
    Locus tag
    AT1G69640
    See related
    Araport:AT1G69640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24J1.22; sphingoid base hydroxylase 1
    Summary
    Encodes one of the two redundant sphingoid base hydroxylases (SBH). Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Double mutants of SBHs were dwarfed and not able to progress from vegetative to reproductive growth.
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    Genomic context

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    See SBH1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (26193618..26195726, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 Neighboring gene ncRNA Neighboring gene F-box/RNI-like superfamily protein Neighboring gene TRAF-like family protein Neighboring gene TRAF-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sphingolipid long-chain base hydroxylation is important for growth and regulation of sphingolipid content and composition in Arabidopsis. Chen M, et al. Plant Cell, 2008 Jul. PMID 18612100, Free PMC Article
    2. Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana. Sperling P, et al. FEBS Lett, 2001 Apr 6. PMID 11297741
    3. Systematic analysis of protein subcellular localization and interaction using high-throughput transient transformation of Arabidopsis seedlings. Marion J, et al. Plant J, 2008 Oct. PMID 18643979
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Double mutants and RNA interference of SBH1 and SBH2 displayed reductions in growth that were dependent on the content of trihydroxy LCBs in sphingolipids. [SBH1]
      Title: Sphingolipid long-chain base hydroxylation is important for growth and regulation of sphingolipid content and composition in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105632.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingolipid C4-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine hydroxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingoid base hydroxylase 1
    NP_177122.2
    • sphingoid base hydroxylase 1 (SBH1); CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sphingoid base hydroxylase 2 (TAIR:AT1G14290.1); Has 2400 Blast hits to 2339 proteins in 395 species: Archae - 0; Bacteria - 406; Metazoa - 416; Fungi - 708; Plants - 429; Viruses - 3; Other Eukaryotes - 438 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26193618..26195726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105632.5 → NP_177122.2  sphingoid base hydroxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177122.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYI1, Q9FWZ2
      UniProtKB/TrEMBL
      A0A178W418, A0A5S9WTP2
      Conserved Domains (1) summary
      pfam04116
      Location:99 → 235
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYI1.1

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