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    TRX5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841082, updated on 22-Aug-2024

    Summary

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    Official Symbol
    TRX5
    Primary source
    Araport:AT1G45145
    Locus tag
    AT1G45145
    See related
    TAIR:AT1G45145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATH5; ATTRX5; F27F5.21; F27F5_21; LIV1; LOCUS OF INSENSITIVITY TO VICTORIN 1; THIOREDOXIN; thioredoxin H-type 5; THIOREDOXIN H-TYPE 5; TRX-h5
    Summary
    encodes a cytosolic thioredoxin that reduces disulfide bridges of target proteins by the reversible formation of a disulfide bridge between two neighboring Cys residues present in the active site. Thioredoxins have been found to regulate a variety of biological reactions in prokaryotic and eukaryotic cells.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (17074942..17076417, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene beta-galactosidase 5 Neighboring gene pseudo Neighboring gene alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis cytosolic thioredoxin h5 gene induction by oxidative stress and its W-box-mediated response to pathogen elicitor. Laloi C, et al. Plant Physiol, 2004 Mar. PMID 14976236, Free PMC Article
    2. Tricking the guard: exploiting plant defense for disease susceptibility. Lorang J, et al. Science, 2012 Nov 2. PMID 23087001, Free PMC Article
    3. Thioredoxin h5 is required for victorin sensitivity mediated by a CC-NBS-LRR gene in Arabidopsis. Sweat TA, et al. Plant Cell, 2007 Feb. PMID 17322408, Free PMC Article
    4. Selective protein denitrosylation activity of Thioredoxin-h5 modulates plant Immunity. Kneeshaw S, et al. Mol Cell, 2014 Oct 2. PMID 25201412
    5. Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins. Tada Y, et al. Science, 2008 Aug 15. PMID 18635760, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thioredoxin-h5 (TRXh5) reverses SNO modifications by acting as a selective protein-SNO reductase.
      Title: Selective protein denitrosylation activity of Thioredoxin-h5 modulates plant Immunity.
    2. in LOV1's absence, victorin inhibits TRX-h5, resulting in compromised defense but not disease by C. victoriae; in LOV1's presence, victorin binding to TRX-h5 activates LOV1 and elicits a resistance-like response that confers disease susceptibility
      Title: Tricking the guard: exploiting plant defense for disease susceptibility.
    3. regulation of NPR1 is through the opposing action of S-nitrosoglutathione and thioredoxins; findings suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity
      Title: Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins.
    4. Data show that thioredoxin h5 (ATTRX5), but not ATTRX3, is highly induced in sensitive Arabidopsis following victorin treatment.
      Title: Thioredoxin h5 is required for victorin sensitivity mediated by a CC-NBS-LRR gene in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_103588.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to microbial phytotoxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    thioredoxin H-type 5
    NP_175128.1
    • thioredoxin H-type 5 (TRX5); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: response to oxidative stress, response to cadmium ion, defense response to fungus, response to microbial phytotoxin; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin 3 (TAIR:AT5G42980.1); Has 18724 Blast hits to 18448 proteins in 2947 species: Archae - 261; Bacteria - 10598; Metazoa - 1825; Fungi - 834; Plants - 1766; Viruses - 10; Other Eukaryotes - 3430 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17074942..17076417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103588.5 → NP_175128.1  thioredoxin H-type 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38881, Q39241, Q56X92, Q9MAJ6
      UniProtKB/TrEMBL
      A0A178WEQ7, A0A5S9WMP6
      Conserved Domains (1) summary
      cd02947
      Location:16 → 108
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39241.1

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