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    SRX sulfiredoxin [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840004, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SRX
    Official Full Name
    sulfiredoxin
    Primary source
    TAIR:AT1G31170
    Locus tag
    AT1G31170
    See related
    Araport:AT1G31170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSRX; F28K20.12; F28K20_12; sulfiredoxin; SULFIREDOXIN
    Summary
    encodes a cysteine-sulfinic acid reductase (sulfiredoxin - EC 1.8.98.2) capable of reducing overoxidized plastidic 2-Cys-Prx involved in peroxide detoxification and response to oxidative stress
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    Genomic context

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    See SRX in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (11133410..11135189)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of sulfiredoxin from Arabidopsis thaliana revealed a more robust antioxidant mechanism in plants. Liu M, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31604522
    2. Dual functions of Arabidopsis sulfiredoxin: acting as a redox-dependent sulfinic acid reductase and as a redox-independent nuclease enzyme. Chi YH, et al. FEBS Lett, 2012 Sep 21. PMID 22967894
    3. The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin. Iglesias-Baena I, et al. Plant Physiol, 2011 Feb. PMID 21139087, Free PMC Article
    4. The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response. Rey P, et al. Plant J, 2007 Feb. PMID 17217469
    5. The contribution of NADPH thioredoxin reductase C (NTRC) and sulfiredoxin to 2-Cys peroxiredoxin overoxidation in Arabidopsis thaliana chloroplasts. Puerto-Galán L, et al. J Exp Bot, 2015 May. PMID 25560178, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Srx crystal structure shows ADP and ATP binding sites.
      Title: The crystal structure of sulfiredoxin from Arabidopsis thaliana revealed a more robust antioxidant mechanism in plants.
    2. An Arabidopsis thaliana double knockout mutant lacking NTRC and Srx shows a phenotype similar to the ntrc mutant, while the srx mutant resembles wild-type plants. NTRC deficiency causes reduced overoxidation of 2-Cys peroxiredoxins.
      Title: The contribution of NADPH thioredoxin reductase C (NTRC) and sulfiredoxin to 2-Cys peroxiredoxin overoxidation in Arabidopsis thaliana chloroplasts.
    3. Srx functions as a nuclease enzyme that can use single-stranded and double-stranded DNAs as substrates.
      Title: Dual functions of Arabidopsis sulfiredoxin: acting as a redox-dependent sulfinic acid reductase and as a redox-independent nuclease enzyme.
    4. Srx is present in mitochondria regardless of the redox state. It retroreduces the inactive sulfinic form of atypical Prx IIF.
      Title: The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin.
    5. AtSrx is a chloroplastic enzyme displaying sulfinic acid reductase activity.
      Title: The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084168.1
    NM_001084169.1
    NM_001332946.1
    NM_102855.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on a sulfur group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfiredoxin
    NP_001077637.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: Sulfiredoxin (InterPro:IPR016692), ParB-like nuclease (InterPro:IPR003115); Has 313 Blast hits to 313 proteins in 133 species: Archae - 0; Bacteria - 130; Metazoa - 88; Fungi - 17; Plants - 42; Viruses - 2; Other Eukaryotes - 34 (source: NCBI BLink).
    NP_001077638.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: Sulfiredoxin (InterPro:IPR016692), ParB-like nuclease (InterPro:IPR003115); Has 206 Blast hits to 206 proteins in 81 species: Archae - 0; Bacteria - 45; Metazoa - 89; Fungi - 3; Plants - 42; Viruses - 2; Other Eukaryotes - 25 (source: NCBI BLink).
    NP_001185121.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: ParB-like nuclease (InterPro:IPR003115).
    NP_564375.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: Sulfiredoxin (InterPro:IPR016692), ParB-like nuclease (InterPro:IPR003115); Has 313 Blast hits to 313 proteins in 133 species: Archae - 0; Bacteria - 130; Metazoa - 88; Fungi - 17; Plants - 42; Viruses - 2; Other Eukaryotes - 34 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11133410..11135189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198192.1 → NP_001185121.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I7W2
      Conserved Domains (2) summary
      smart00470
      Location:41 → 122
      ParB; ParB-like nuclease domain
      COG1475
      Location:39 → 121
      Spo0J; Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, cell division, chromosome partitioning]

    2. NM_102855.4 → NP_564375.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS24, Q8GY89, Q8LC51, Q9SA12
      UniProtKB/TrEMBL
      A0A178WH65, A0A5S9WJJ1
      Conserved Domains (1) summary
      cd16395
      Location:40 → 124
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation

    3. NM_001332946.1 → NP_001321339.1  sulfiredoxin [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQM5
      Conserved Domains (1) summary
      cd16395
      Location:40 → 121
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation

    4. NM_001084169.1 → NP_001077638.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077638.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY89
      Conserved Domains (2) summary
      smart00470
      Location:41 → 119
      ParB; ParB-like nuclease domain
      COG1475
      Location:39 → 119
      Spo0J; Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001084168.1 → NP_001077637.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS24, Q8GY89, Q8LC51, Q9SA12
      UniProtKB/TrEMBL
      A0A178WH65, A0A5S9WJJ1
      Conserved Domains (1) summary
      cd16395
      Location:40 → 124
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY89.1

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