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    GA2OX2 gibberellin 2-oxidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839883, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GA2OX2
    Official Full Name
    gibberellin 2-oxidase
    Primary source
    TAIR:AT1G30040
    Locus tag
    AT1G30040
    See related
    Araport:AT1G30040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGA2OX2; gibberellin 2-oxidase; GIBBERELLIN 2-OXIDASE 2; T1P2.6; T1P2_6
    Summary
    Encodes a gibberellin 2-oxidase that acts on C-19 gibberellins. AtGA2OX2 expression is responsive to cytokinin and KNOX activities.
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    Genomic context

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    See GA2OX2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (10537457..10540044)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Intron maturase, type II family protein Neighboring gene hypothetical protein (Protein of unknown function, DUF538) Neighboring gene pseudo Neighboring gene tropomyosin Neighboring gene COP1-interacting protein-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant-Specific Histone Deacetylases HDT1/2 Regulate GIBBERELLIN 2-OXIDASE2 Expression to Control Arabidopsis Root Meristem Cell Number. Li H, et al. Plant Cell, 2017 Sep. PMID 28855334, Free PMC Article
    2. Molecular cloning and functional expression of gibberellin 2- oxidases, multifunctional enzymes involved in gibberellin deactivation. Thomas SG, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200325, Free PMC Article
    3. Regulation of hormone metabolism in Arabidopsis seeds: phytochrome regulation of abscisic acid metabolism and abscisic acid regulation of gibberellin metabolism. Seo M, et al. Plant J, 2006 Nov. PMID 17010113
    4. PIL5, a phytochrome-interacting bHLH protein, regulates gibberellin responsiveness by binding directly to the GAI and RGA promoters in Arabidopsis seeds. Oh E, et al. Plant Cell, 2007 Apr. PMID 17449805, Free PMC Article
    5. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that by repressing the expression of GA2ox2, HDT1/2 likely fine-tune gibberellin metabolism.
      Title: Plant-Specific Histone Deacetylases HDT1/2 Regulate GIBBERELLIN 2-OXIDASE2 Expression to Control Arabidopsis Root Meristem Cell Number.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001036035.2
    NM_102743.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables C-19 gibberellin 2-beta-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C-19 gibberellin 2-beta-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    involved_in gibberellin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gibberellin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red or far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    gibberellin 2-oxidase
    NP_001031112.1
    • gibberellin 2-oxidase (GA2OX2); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: gibberellin 2-oxidase 3 (TAIR:AT2G34555.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_174296.1
    • gibberellin 2-oxidase (GA2OX2); CONTAINS InterPro DOMAIN/s: Isopenicillin N synthase (InterPro:IPR002283), Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: gibberellin 2-oxidase 3 (TAIR:AT2G34555.1); Has 8540 Blast hits to 8490 proteins in 994 species: Archae - 0; Bacteria - 1137; Metazoa - 84; Fungi - 1033; Plants - 4909; Viruses - 0; Other Eukaryotes - 1377 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10537457..10540044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102743.3 → NP_174296.1  gibberellin 2-oxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174296.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I385, Q9XFR9
      UniProtKB/TrEMBL
      A0A178WMY6, A0A5S9WFL2
      Conserved Domains (1) summary
      PLN02156
      Location:1 → 340
      PLN02156; gibberellin 2-beta-dioxygenase

    2. NM_001036035.2 → NP_001031112.1  gibberellin 2-oxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WJC0
      Conserved Domains (2) summary
      pfam03171
      Location:180 → 253
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
      pfam14226
      Location:31 → 125
      DIOX_N; non-haem dioxygenase in morphine synthesis N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XFR9.1

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