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    CYP72C1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838276, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CYP72C1
    Primary source
    Araport:AT1G17060
    Locus tag
    AT1G17060
    See related
    TAIR:AT1G17060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHI2; CHIBI 2; cytochrome p450 72c1; F20D23.24; F20D23_24; SHK1; SHRINK 1; SOB7; SUPPRESSOR OF PHYB-4 7
    Summary
    Encodes a protein with similarity to other cytochrome P450's and is a homolog of BAS1. Over expression causes a dwarf phenotype resembling brassinolide resistant mutants. Double mutant analysis of sob7/bas1 loss of function mutants suggests these genes have redundant functions in light responsiveness. SOB7 may function in metabolizing brassinolides. Expressed in leaf, root, stem and silique but expression highest in flower and cauline leaves. Dominant overexpressing plants have dwarf phenotype, short siliques/seeds, rounded dark green leaves and short hypocotyls in light and dark. Loss of function alleles result in plants with long hypocotyls.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (5832094..5835488, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene SH2 domain protein A Neighboring gene ncRNA Neighboring gene solanesyl diphosphate synthase 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene GC-rich sequence DNA-binding factor-like protein with Tuftelin interacting domain-containing protein Neighboring gene Ribosomal protein L18ae family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis CYP72C1 is an atypical cytochrome P450 that inactivates brassinosteroids. Thornton LE, et al. Plant Mol Biol, 2010 Sep. PMID 20669042
    2. shk1-D, a dwarf Arabidopsis mutant caused by activation of the CYP72C1 gene, has altered brassinosteroid levels. Takahashi N, et al. Plant J, 2005 Apr. PMID 15773850
    3. Activation of the cytochrome P450 gene, CYP72C1, reduces the levels of active brassinosteroids in vivo. Nakamura M, et al. J Exp Bot, 2005 Mar. PMID 15689343
    4. BAS1 and SOB7 act redundantly to modulate Arabidopsis photomorphogenesis via unique brassinosteroid inactivation mechanisms. Turk EM, et al. Plant J, 2005 Apr. PMID 15773851
    5. CIRCADIAN CLOCK ASSOCIATED 1 and ATAF2 differentially suppress cytochrome P450-mediated brassinosteroid inactivation. Peng H, et al. J Exp Bot, 2020 Jan 23. PMID 31639820, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIRCADIAN CLOCK ASSOCIATED 1 and ATAF2 differentially suppress cytochrome P450-mediated brassinosteroid inactivation.
      Title: CIRCADIAN CLOCK ASSOCIATED 1 and ATAF2 differentially suppress cytochrome P450-mediated brassinosteroid inactivation.
    2. Three-dimensional models indicate that the active site of CYP72C1 does not contain several conserved amino acids typically needed for substrate hydroxylation.
      Title: Arabidopsis CYP72C1 is an atypical cytochrome P450 that inactivates brassinosteroids.
    3. BAS1 and SOB7 act redundantly with respect to light promotion of cotyledon expansion, repression of hypocotyl elongation and flowering time in addition to other phenotypes not regulated by light.
      Title: BAS1 and SOB7 act redundantly to modulate Arabidopsis photomorphogenesis via unique brassinosteroid inactivation mechanisms.
    4. An Arabidopsis dwarf mutant, shrink1-D (shk1-D), was isolated and the phenotype was shown to be caused by activation of the CYP72C1 gene.
      Title: shk1-D, a dwarf Arabidopsis mutant caused by activation of the CYP72C1 gene, has altered brassinosteroid levels.
    5. The brassinosteroid synthesis of wild-type and mutant strains of the cytochrome P450 gene, CYP72C1 in A. thaliana is reported [CYP72C1].
      Title: Activation of the cytochrome P450 gene, CYP72C1, reduces the levels of active brassinosteroids in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001332275.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables brassinosteroid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome p450 72c1
    NP_001319024.1
    • cytochrome p450 72c1 (CYP72C1); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: response to light stimulus, brassinosteroid metabolic process, unidimensional cell growth; LOCATED IN: endomembrane system; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 72, subfamily A, polypeptide 15 (TAIR:AT3G14690.1); Has 27908 Blast hits to 27397 proteins in 1448 species: Archae - 65; Bacteria - 2698; Metazoa - 11276; Fungi - 5119; Plants - 7743; Viruses - 3; Other Eukaryotes - 1004 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5832094..5835488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332275.1 → NP_001319024.1  cytochrome p450 72c1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9USZ2
    Nucleotide Protein
    Heading Accession and Version

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