DMR6 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DMR6
Official Full Name: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein
Primary source: TAIR:AT5G24530
Locus tag: AT5G24530
See related: Araport:AT5G24530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DOWNY MILDEW RESISTANT 6; K18P6.6; K18P6_6
Summary: Encodes a putative 2OG-Fe(II) oxygenase that is defense-associated but required for susceptibility to downy mildew.
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Genomic context

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See DMR6 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (8378759..8383401)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the discovery and functional characterization of DMR6 as a salicylic acid 5-hydroxylase (S5H) that catalyzes the formation of 2,5-Dihydroxybenzoic acid.
Title: S5H/DMR6 Encodes a Salicylic Acid 5-Hydroxylase That Fine-Tunes Salicylic Acid Homeostasis.
DMR6 protein has flavone synthase activity and is expressed during development with high expression in cauline and senescing leaves.
Title: The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions.
Data conclude that DMR6 and DLO1 redundantly suppress plant immunity, but also have distinct activities based on their differential localization of expression.
Title: DOWNY MILDEW RESISTANT 6 and DMR6-LIKE OXYGENASE 1 are partially redundant but distinct suppressors of immunity in Arabidopsis.
DMR6 encodes a 2-oxoglutarate (2OG)-Fe(II) oxygenase which is required for susceptibility to H. parasitica. Expression analysis of dmr6 mutants showed the enhanced expression of a subset of defense-associated genes, including DMR6 itself. [DMR6]
Title: Arabidopsis DMR6 encodes a putative 2OG-Fe(II) oxygenase that is defense-associated but required for susceptibility to downy mildew.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_122361.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables flavone synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables salicylate 5-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flavonoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to fungus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to fungus	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oomycetes	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in salicylic acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

NP_197841.1

DOWNY MILDEW RESISTANT 6 (DMR6); FUNCTIONS IN: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity; INVOLVED IN: response to fungus, response to bacterium, flavonoid biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT4G10490.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8378759..8383401

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122361.4 → NP_197841.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197841.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LEJ4, Q9FLV0

UniProtKB/TrEMBL

A0A178UM31, A0A5S9Y747, A0A654G423

Conserved Domains (1) summary

PLN02639
Location:1 → 340

PLN02639; oxidoreductase, 2OG-Fe(II) oxygenase family protein