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    ADK2 adenosine kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831882, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADK2
    Official Full Name
    adenosine kinase 2
    Primary source
    TAIR:AT5G03300
    Locus tag
    AT5G03300
    See related
    Araport:AT5G03300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adenosine kinase 2; ADENOSINE KINASE 2; F12E4.30; F12E4_30
    Summary
    Encodes adenosine kinase 2 (ADK2), a typical, constitutively expressed housekeeping enzyme. Shows a high sequence identity with ADK1. Involved in salvage synthesis of adenylates and methyl recycling. Enzyme activity is substantially inhibited in roots, siliques and dry seeds by an unknown compound. May contribute to cytokinin interconversion.
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    Genomic context

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    See ADK2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (796361..799810)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase V Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine kinase of Arabidopsis. Kinetic properties and gene expression. Moffatt BA, et al. Plant Physiol, 2000 Dec. PMID 11115893, Free PMC Article
    2. A complex containing SNF1-related kinase (SnRK1) and adenosine kinase in Arabidopsis. Mohannath G, et al. PLoS One, 2014. PMID 24498147, Free PMC Article
    3. Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry. Kung CC, et al. Proteomics, 2006 May. PMID 16526091
    4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120408.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables copper ion binding HDA PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adenosine salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    adenosine kinase 2
    NP_195950.1
    • adenosine kinase 2 (ADK2); FUNCTIONS IN: adenosine kinase activity, copper ion binding, kinase activity; INVOLVED IN: adenosine salvage; LOCATED IN: plasma membrane; EXPRESSED IN: 33 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173), Adenosine kinase (InterPro:IPR001805); BEST Arabidopsis thaliana protein match is: adenosine kinase 1 (TAIR:AT3G09820.1); Has 9730 Blast hits to 9724 proteins in 1887 species: Archae - 143; Bacteria - 5874; Metazoa - 382; Fungi - 207; Plants - 398; Viruses - 0; Other Eukaryotes - 2726 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      796361..799810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342696.1 → NP_001330384.1  adenosine kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UGH7, A0A1P8BAP0

    2. NM_001342697.1 → NP_001330385.1  adenosine kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UGH7, A0A1P8BAP0

    3. NM_120408.4 → NP_195950.1  adenosine kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LZG0
      UniProtKB/TrEMBL
      A0A178UGH7
      Conserved Domains (1) summary
      PLN02548
      Location:14 → 345
      PLN02548; adenosine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZG0.1

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